Year |
Citation |
Score |
2022 |
Leissing TM, Hardy AP, Chan H, Wang Y, Tumber A, Chowdhury R, Fang P, Coleman ML, Cockman ME, Kramer HB, Berridge G, Fischer R, Kessler BM, Ratcliffe PJ, Lu X, et al. Factor inhibiting HIF can catalyse two asparaginyl-hydroxylations in VNVN motifs of ankyrin fold proteins. The Journal of Biological Chemistry. 102020. PMID 35537551 DOI: 10.1016/j.jbc.2022.102020 |
0.663 |
|
2020 |
Choi H, Hardy AP, Leissing TM, Chowdhury R, Nakashima Y, Ge W, Markoulides M, Scotti JS, Gerken PA, Thorbjornsrud H, Kang D, Hong S, Lee J, McDonough MA, Park H, et al. A human protein hydroxylase that accepts D-residues. Communications Chemistry. 3: 52. PMID 36703414 DOI: 10.1038/s42004-020-0290-5 |
0.667 |
|
2020 |
Liu T, Abboud MI, Chowdhury R, Tumber A, Hardy AP, Lippl K, Lohans CT, Pires E, Wickens J, McDonough MA, West CM, Schofield CJ. Biochemical and biophysical analyses of hypoxia sensing prolyl hydroxylases from Dictyostelium discoideum and Toxoplasma gondii. The Journal of Biological Chemistry. PMID 32934009 DOI: 10.1074/Jbc.Ra120.013998 |
0.73 |
|
2020 |
Choi H, Hardy AP, Leissing TM, Chowdhury R, Nakashima Y, Ge W, Markoulides M, Scotti JS, Gerken PA, Thorbjornsrud H, Kang D, Hong S, Lee J, McDonough MA, Park H, et al. A human protein hydroxylase that accepts D-residues Communications Chemistry. 3. DOI: 10.1038/s42004-020-0290-5 |
0.63 |
|
2016 |
Chowdhury R, Leung IK, Tian YM, Abboud MI, Ge W, Domene C, Cantrelle FX, Landrieu I, Hardy AP, Pugh CW, Ratcliffe PJ, Claridge TD, Schofield CJ. Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases. Nature Communications. 7: 12673. PMID 27561929 DOI: 10.1038/Ncomms12673 |
0.623 |
|
2015 |
Tarhonskaya H, Hardy AP, Howe EA, Loik ND, Kramer HB, McCullagh JS, Schofield CJ, Flashman E. Kinetic Investigations of the Role of Factor Inhibiting Hypoxia-Inducible Factor (FIH) as an Oxygen Sensor. The Journal of Biological Chemistry. PMID 26112411 DOI: 10.1074/Jbc.M115.653014 |
0.436 |
|
2015 |
Jayatunga MK, Thompson S, McKee TC, Chan MC, Reece KM, Hardy AP, Sekirnik R, Seden PT, Cook KM, McMahon JB, Figg WD, Schofield CJ, Hamilton AD. Inhibition of the HIF1α-p300 interaction by quinone- and indandione-mediated ejection of structural Zn(II). European Journal of Medicinal Chemistry. 94: 509-16. PMID 25023609 DOI: 10.1016/J.Ejmech.2014.06.006 |
0.436 |
|
2013 |
Yang M, Hardy AP, Chowdhury R, Loik ND, Scotti JS, McCullagh JS, Claridge TD, McDonough MA, Ge W, Schofield CJ. Substrate selectivity analyses of factor inhibiting hypoxia-inducible factor. Angewandte Chemie (International Ed. in English). 52: 1700-4. PMID 23296631 DOI: 10.1002/Anie.201208046 |
0.661 |
|
2013 |
Leung IK, Demetriades M, Hardy AP, Lejeune C, Smart TJ, Szöllössi A, Kawamura A, Schofield CJ, Claridge TD. Reporter ligand NMR screening method for 2-oxoglutarate oxygenase inhibitors. Journal of Medicinal Chemistry. 56: 547-55. PMID 23234607 DOI: 10.1021/Jm301583M |
0.654 |
|
2012 |
Ge W, Wolf A, Feng T, Ho CH, Sekirnik R, Zayer A, Granatino N, Cockman ME, Loenarz C, Loik ND, Hardy AP, Claridge TD, Hamed RB, Chowdhury R, Gong L, et al. Oxygenase-catalyzed ribosome hydroxylation occurs in prokaryotes and humans. Nature Chemical Biology. 8: 960-2. PMID 23103944 DOI: 10.1038/Nchembio.1093 |
0.637 |
|
2009 |
Hardy AP, Prokes I, Kelly L, Campbell ID, Schofield CJ. Asparaginyl beta-hydroxylation of proteins containing ankyrin repeat domains influences their stability and function. Journal of Molecular Biology. 392: 994-1006. PMID 19646994 DOI: 10.1016/J.Jmb.2009.07.070 |
0.435 |
|
2008 |
Hewitson KS, Holmes SL, Ehrismann D, Hardy AP, Chowdhury R, Schofield CJ, McDonough MA. Evidence that two enzyme-derived histidine ligands are sufficient for iron binding and catalysis by factor inhibiting HIF (FIH). The Journal of Biological Chemistry. 283: 25971-8. PMID 18611856 DOI: 10.1074/Jbc.M804999200 |
0.633 |
|
2008 |
Chowdhury R, Hardy A, Schofield CJ. The human oxygen sensing machinery and its manipulation. Chemical Society Reviews. 37: 1308-19. PMID 18568157 DOI: 10.1039/B701676J |
0.585 |
|
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