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Nathan Rose - Publications

Affiliations: 
University of Oxford, Oxford, United Kingdom 
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25 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Rose NR, King HW, Blackledge NP, Fursova NA, Ember KJ, Fischer R, Kessler BM, Klose RJ. RYBP stimulates PRC1 to shape chromatin-based communication between Polycomb repressive complexes. Elife. 5. PMID 27705745 DOI: 10.7554/eLife.18591  0.344
2015 Hopkinson RJ, Leung IK, Smart TJ, Rose NR, Henry L, Claridge TD, Schofield CJ. Studies on the Glutathione-Dependent Formaldehyde-Activating Enzyme from Paracoccus denitrificans. Plos One. 10: e0145085. PMID 26675168 DOI: 10.1371/Journal.Pone.0145085  0.417
2014 Rose NR, Klose RJ. Understanding the relationship between DNA methylation and histone lysine methylation. Biochimica Et Biophysica Acta. 1839: 1362-72. PMID 24560929 DOI: 10.1016/j.bbagrm.2014.02.007  0.35
2013 Hopkinson RJ, Tumber A, Yapp C, Chowdhury R, Aik W, Che KH, Li XS, Kristensen JB, King ON, Chan MC, Yeoh KK, Choi H, Walport LJ, Thinnes CC, Bush JT, ... ... Rose NR, et al. 5-Carboxy-8-hydroxyquinoline is a Broad Spectrum 2-Oxoglutarate Oxygenase Inhibitor which Causes Iron Translocation. Chemical Science (Royal Society of Chemistry : 2010). 4: 3110-3117. PMID 26682036 DOI: 10.1039/C3Sc51122G  0.794
2013 Hopkinson RJ, Walport LJ, Münzel M, Rose NR, Smart TJ, Kawamura A, Claridge TD, Schofield CJ. Is JmjC oxygenase catalysis limited to demethylation? Angewandte Chemie (International Ed. in English). 52: 7709-13. PMID 23788451 DOI: 10.1002/Anie.201303282  0.669
2013 Chowdhury R, Candela-Lena JI, Chan MC, Greenald DJ, Yeoh KK, Tian YM, McDonough MA, Tumber A, Rose NR, Conejo-Garcia A, Demetriades M, Mathavan S, Kawamura A, Lee MK, van Eeden F, et al. Selective small molecule probes for the hypoxia inducible factor (HIF) prolyl hydroxylases. Acs Chemical Biology. 8: 1488-96. PMID 23683440 DOI: 10.1021/Cb400088Q  0.735
2013 Hopkinson RJ, Tumber A, Yapp C, Chowdhury R, Aik W, Che KH, Li XS, Kristensen JBL, King ONF, Chan MC, Yeoh KK, Choi H, Walport LJ, Thinnes CC, Bush JT, ... ... Rose NR, et al. 5-Carboxy-8-hydroxyquinoline is a broad spectrum 2-oxoglutarate oxygenase inhibitor which causes iron translocation Chemical Science. 4: 3110-3117. DOI: 10.1039/c3sc51122g  0.749
2012 Rose NR, Woon EC, Tumber A, Walport LJ, Chowdhury R, Li XS, King ON, Lejeune C, Ng SS, Krojer T, Chan MC, Rydzik AM, Hopkinson RJ, Che KH, Daniel M, et al. Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases. Journal of Medicinal Chemistry. 55: 6639-43. PMID 22724510 DOI: 10.1021/Jm300677J  0.786
2012 Chalker JM, Lercher L, Rose NR, Schofield CJ, Davis BG. Conversion of cysteine into dehydroalanine enables access to synthetic histones bearing diverse post-translational modifications. Angewandte Chemie (International Ed. in English). 51: 1835-9. PMID 22247073 DOI: 10.1002/Anie.201106432  0.531
2012 Woon EC, Tumber A, Kawamura A, Hillringhaus L, Ge W, Rose NR, Ma JH, Chan MC, Walport LJ, Che KH, Ng SS, Marsden BD, Oppermann U, McDonough MA, Schofield CJ. Linking of 2-oxoglutarate and substrate binding sites enables potent and highly selective inhibition of JmjC histone demethylases. Angewandte Chemie (International Ed. in English). 51: 1631-4. PMID 22241642 DOI: 10.1002/Anie.201107833  0.758
2011 Hillringhaus L, Yue WW, Rose NR, Ng SS, Gileadi C, Loenarz C, Bello SH, Bray JE, Schofield CJ, Oppermann U. Structural and evolutionary basis for the dual substrate selectivity of human KDM4 histone demethylase family. The Journal of Biological Chemistry. 286: 41616-25. PMID 21914792 DOI: 10.1074/Jbc.M111.283689  0.786
2011 Chowdhury R, Yeoh KK, Tian YM, Hillringhaus L, Bagg EA, Rose NR, Leung IK, Li XS, Woon EC, Yang M, McDonough MA, King ON, Clifton IJ, Klose RJ, Claridge TD, et al. The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases. Embo Reports. 12: 463-9. PMID 21460794 DOI: 10.1038/Embor.2011.43  0.714
2011 Chang KH, King ON, Tumber A, Woon EC, Heightman TD, McDonough MA, Schofield CJ, Rose NR. Inhibition of histone demethylases by 4-carboxy-2,2'-bipyridyl compounds. Chemmedchem. 6: 759-64. PMID 21412984 DOI: 10.1002/Cmdc.201100026  0.827
2011 Rose NR, McDonough MA, King ON, Kawamura A, Schofield CJ. Inhibition of 2-oxoglutarate dependent oxygenases. Chemical Society Reviews. 40: 4364-97. PMID 21390379 DOI: 10.1039/C0Cs00203H  0.752
2011 Thalhammer A, Mecinović J, Loenarz C, Tumber A, Rose NR, Heightman TD, Schofield CJ. Inhibition of the histone demethylase JMJD2E by 3-substituted pyridine 2,4-dicarboxylates. Organic & Biomolecular Chemistry. 9: 127-35. PMID 21076780 DOI: 10.1039/C0Ob00592D  0.796
2010 King ON, Li XS, Sakurai M, Kawamura A, Rose NR, Ng SS, Quinn AM, Rai G, Mott BT, Beswick P, Klose RJ, Oppermann U, Jadhav A, Heightman TD, Maloney DJ, et al. Quantitative high-throughput screening identifies 8-hydroxyquinolines as cell-active histone demethylase inhibitors. Plos One. 5: e15535. PMID 21124847 DOI: 10.1371/Journal.Pone.0015535  0.795
2010 Sekirnik R, Rose NR, Mecinović J, Schofield CJ. 2-Oxoglutarate oxygenases are inhibited by a range of transition metals. Metallomics : Integrated Biometal Science. 2: 397-9. PMID 21072385 DOI: 10.1039/C004952B  0.495
2010 Kawamura A, Tumber A, Rose NR, King ON, Daniel M, Oppermann U, Heightman TD, Schofield C. Development of homogeneous luminescence assays for histone demethylase catalysis and binding. Analytical Biochemistry. 404: 86-93. PMID 20435012 DOI: 10.1016/J.Ab.2010.04.030  0.769
2010 Hopkinson RJ, Hamed RB, Rose NR, Claridge TD, Schofield CJ. Monitoring the activity of 2-oxoglutarate dependent histone demethylases by NMR spectroscopy: direct observation of formaldehyde. Chembiochem : a European Journal of Chemical Biology. 11: 506-10. PMID 20095001 DOI: 10.1002/Cbic.200900713  0.69
2010 Sakurai M, Rose NR, Schultz L, Quinn AM, Jadhav A, Ng SS, Oppermann U, Schofield CJ, Simeonov A. A miniaturized screen for inhibitors of Jumonji histone demethylases. Molecular Biosystems. 6: 357-64. PMID 20094655 DOI: 10.1039/B912993F  0.5
2010 Rose NR, Woon EC, Kingham GL, King ON, Mecinović J, Clifton IJ, Ng SS, Talib-Hardy J, Oppermann U, McDonough MA, Schofield CJ. Selective inhibitors of the JMJD2 histone demethylases: combined nondenaturing mass spectrometric screening and crystallographic approaches. Journal of Medicinal Chemistry. 53: 1810-8. PMID 20088513 DOI: 10.1021/Jm901680B  0.806
2010 Loenarz C, Ge W, Coleman ML, Rose NR, Cooper CD, Klose RJ, Ratcliffe PJ, Schofield CJ. PHF8, a gene associated with cleft lip/palate and mental retardation, encodes for an Nepsilon-dimethyl lysine demethylase. Human Molecular Genetics. 19: 217-22. PMID 19843542 DOI: 10.1093/Hmg/Ddp480  0.748
2009 Sekirnik R, Rose NR, Thalhammer A, Seden PT, Mecinović J, Schofield CJ. Inhibition of the histone lysine demethylase JMJD2A by ejection of structural Zn(II). Chemical Communications (Cambridge, England). 6376-8. PMID 19841782 DOI: 10.1039/B916357C  0.598
2008 Rose NR, Ng SS, Mecinović J, Liénard BM, Bello SH, Sun Z, McDonough MA, Oppermann U, Schofield CJ. Inhibitor scaffolds for 2-oxoglutarate-dependent histone lysine demethylases. Journal of Medicinal Chemistry. 51: 7053-6. PMID 18942826 DOI: 10.1021/Jm800936S  0.729
2007 Ng SS, Kavanagh KL, McDonough MA, Butler D, Pilka ES, Lienard BM, Bray JE, Savitsky P, Gileadi O, von Delft F, Rose NR, Offer J, Scheinost JC, Borowski T, Sundstrom M, et al. Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity. Nature. 448: 87-91. PMID 17589501 DOI: 10.1038/Nature05971  0.721
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