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High-probability grants
According to our matching algorithm, Mary T. Mendonca is the likely recipient of the following grants.
Years |
Recipients |
Code |
Title / Keywords |
Matching score |
1989 — 1990 |
Mendonca, Mary T |
F32Activity Code Description: To provide postdoctoral research training to individuals to broaden their scientific background and extend their potential for research in specified health-related areas. |
Environmental Activation of the Neual Bases of Mating @ University of Texas Austin |
0.961 |
1992 — 1993 |
Mendonca, Mary |
N/AActivity Code Description: No activity code was retrieved: click on the grant title for more information |
Behavioral and Neuroendocrine Control of Reproduction in a Sex Reversing Frog
This study will: 1) explore the generality of the natural sex- reversing ability of Hyperolius viridiflavus in the field. A chromosomal analysis will attempt to determine the frequency of sex-reversed individuals. 2) establish a breeding colony of these frogs. 3) analyze plasma, gonad and larynx samples of the three categories of animals (females, genetic and sex-reversed males) and correlate circulating sec steroid levels to morphological and behavioral changes. 4) compare volumes of hypothalamic brain nuclei of individuals in the three categories and in females treated with testosterone and flutamide, an anti-androgen. 5) test the effectiveness of i.) group composition, ii.) exogenous testosterone and flutamide and iii.) gonadotropin releasing hormone agonist and antagonist in affecting sex-reversal in females housed in different group situations. 6) record vocalizations of genetic and sex- reversed males, analyze the recording to determine if they differ, and if so, initiate call playback experiments in the field to determine if females distinguish between the two. The data obtained in this preliminary venture will provide a springboard to many future studies ranging from the neuroendocrine to the evolutionary in scope. This unique model system is sure to provide new insights into mechanisms controlling sec at both the proximate and ultimate levels.
|
0.915 |
1997 — 2001 |
Mendonca, Mary T |
R29Activity Code Description: Undocumented code - click on the grant title for more information. |
A New Neuroendocrine Model of Seasonal Behaviors @ Auburn University At Auburn
DESCRIPTION (adapted from applicant's abstract): Comparative studies shed light on alternate neuroendocrine mechanisms underlying reproduction and its attendant sexual behaviors. By exploring alternate mechanisms and comparing them to the established paradigm, one can illuminate which neural substrates are basic and critical tot he expression of these behaviors. Bats are the second most prolific radiation of mammals yet they remain relatively unstudied. They display great diversity in their reproductive patterns and vespertilionid bats, in particular, constitute an excellent alternative model system to study neuroendocrine mechanisms affecting reproductive behavior due to unique features of their life history. They 1) have a dissociated pattern of reproduction, mating when gonads are regressed and sex steroids are basal, and 2) are heterothermic, with arousal from hibernation being a potent and rapid stimulator of sexual behavior. Therefore, an external cue (i.e. temperature change) appears to activate sexual behavior independent of the classical role played by sex steroids. Preliminary data indicate that male and female big brown bats, Eptesicus fuscus, a vespertilionid, can mate months (at least 6 for males and 18 for females) after gonadectomy when given the proper temperature regimen. The specific research objectives of this proposal are to test the hypotheses that this species has 1) become relatively (if not completely) independent of sex steroids as an activator of reproductive behavior and sexual behavior. If these hypotheses are supported, the PI proposes a starting point to explore which alternative neuroendocrine mechanisms may be replacing the classic mechanism of sex steroid activation of sexual behavior. To achieve these objectives, two intertwined lines of research will be established. One will document the extent to which the expression of sexual behavior by males and females is independent from gonadal sex steroids by removal of gonads at different points in the seasonal cycle as well as removal of possible extragonadal sources of sex steroids. Replacement sex steroids will be given at these points to determine their efficacy in re-instating the behavior in animals. The second line will document the pattern of torpor and arousal and how sex steroids change in relation to these states. It will also determine what degree of exposure to low temperature (or entrance into a torpid state) insures the expression of mating and how this is modified by the presence or absence of sex steroids. Preliminary experiments will administer intracerebroventricular doses of GnRH antagonist and agonist to begin testing if this is a potential neuroendocrine mechanism linking arousal from hibernation and mating in this species.
|
1 |
2015 — 2018 |
Mendonca, Mary |
N/AActivity Code Description: No activity code was retrieved: click on the grant title for more information |
Collaborative Research: Determining the Mechanisms by Which Parental Testosterone Biases the Ratio of Male to Female Birds
Female birds determine the sex of offspring because they are heterogametic, but they also control the ratio of male to female offspring, the sex ratio, in response to environmental variables. Recent work shows that testosterone (T) treatment induces male-biased sex ratios in multiple species, and that it may do so by influencing which sex chromosome is retained in the oocyte during meiosis I (i.e. segregation distortion). The idea that a hormone can influence the genetic material inherited by offspring has enormous potential not only for understanding sex ratio adjustment in all vertebrate systems, but also when considering the inheritance of other genetic traits that determine offspring phenotype. The work will advance understanding of how the environment and endocrine system work together to determine genetic inheritance, as well as the cellular dynamics of meiosis. The researchers will also generate educational modules for both high school students and teachers and collaborate on potential applications of this work to poultry production. The research will also afford research training opportunities to numerous undergraduate and graduate students and continue their participation in programs geared towards involving under-represented groups in science.
The results of previous data support the hypothesis that T stimulates male-biased sex ratios through segregation distortion of sex chromosomes during meiosis. To further analyze the effects of maternal testosterone, studies are planned to: test for the presence of androgen receptors on the germinal disc and follicle cells near the time of meiotic segregation; test for changes in the expression of genes involved in spindle fiber formation and chromosome movement in oocytes collected from T-treated hens; and to determine whether T elevations at meiotic segregation are necessary for sex ratio biases. Histologic, endocrine, and transcriptomic analyses are planned in association with the studies. The research is expected to reveal the intracellular pathway responsible for segregation distortion, to identify key points of regulation, and to determine how the pathways respond to changes in environmental and social conditions shown to influence offspring sex ratios. Results from the studies will be published in peer-reviewed journals and presented at regional and national scientific meetings.
|
0.915 |