Area:
peptides, endomorphins, pain, reward
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High-probability grants
According to our matching algorithm, Kristen A. Horner is the likely recipient of the following grants.
| Years |
Recipients |
Code |
Title / Keywords |
Matching
score |
| 1998 — 2002 |
Horner, Kristen A |
F31Activity Code Description:
To provide predoctoral individuals with supervised research training in specified health and health-related areas leading toward the research degree (e.g., Ph.D.). |
Changes in Endomorphins During Opiate Tolerance @ Tulane University of Louisiana
DESCRIPTION: (Applicant's Abstract) Opiate tolerance and dependence are complex phenomena, and may involve, in part, alterations in endogenous opioid peptide concentrations. We will examine the effects of chronic mu opiate receptor agonists on concentrations of endogenous opioid peptides and mu opiate receptors. Specific Aim I will address the effects of chronic of morphine, endomorphin-1 and 2 (two newly discovered endogenous mu agonists) on the levels of mu receptors, endomorphin-1 and 2 in SH-SYSY cells, using radioimmunoassay (with antibodies generated and characterized in this lab). Specific Aim II will address the effects of chronic morphine, and endomorphin-1 and -2 administration on the levels of mu receptors and endomorphin- l and 2 in the rat spinal cord, using immunocytochemistry. In order to examine the mu opiate receptor's role in regulating endomorphin-1 and 2 peptide levels, in Specific Aim III, we will inactivate the mu opiate receptor in the rat spinal cord, and analyze the changes in endomorphin- I and 2 levels, using immunocytochemistry. Elucidation of the effects of chronic opiate administration on endogenous opioid peptide systems will help us to develop an understanding of the mechanisms of opiate tolerance and dependence.
|
1 |
| 2009 |
Horner, Kristen A |
R15Activity Code Description:
Supports small-scale research projects at educational institutions that provide baccalaureate or advanced degrees for a significant number of the Nation’s research scientists but that have not been major recipients of NIH support. The goals of the program are to (1) support meritorious research, (2) expose students to research, and (3) strengthen the research environment of the institution. Awards provide limited Direct Costs, plus applicable F&A costs, for periods not to exceed 36 months. This activity code uses multi-year funding authority; however, OER approval is NOT needed prior to an IC using this activity code. |
The Role of Mu Opioid Receptor Activation in Psychostimulant-Induced Gene Express @ Mercer University Macon
DESCRIPTION (provided by applicant): Methamphetamine (METH) use can result in the development of repetitive behaviors that may be related to enhanced gene expression in the neurons of the rostral patch compartment of dorsal striatum, relative to the surrounding rostral matrix compartment. Mu opioid receptors are densely expressed on the neurons of the patch compartment, and their activation may contribute to METH-induced changes in gene expression within the patch compartment. We posit that during METH use, endogenous mu opioid receptor ligands are released into the dorsal striatum where they activate mu opioid receptors on the neurons of the rostral patch compartment and increase gene expression within the patch compartment, resulting in changes in behavior. The goal of this application is to determine the role of mu opioid receptor activation on METH-induced changes in gene expression in the rostral patch compartment of dorsal striatum and behavior. Specific Aim I will examine the effects of an intrastriatally infused mu opioid receptor antagonist on METH-induced gene expression in the rostral patch and matrix compartments and behavior. Specific Aim II will involve examination of the effects of an intrastriatally infused mu opioid receptor agonist on METH-induced gene expression in the rostral patch and matrix compartments and behavior. In the long term, the data from these studies will provide the basis for further elucidation of the functional differences between the patch and matrix compartments of dorsal striatum and their roles in the expression of repetitive behaviors. The information generated from this proposal may also aid in developing potential therapeutic interventions for treating the untoward neurochemical and behavioral effects of METH use. One of the undesirable effects of psychostimulant use is the development of uncontrollable, repetitive behaviors, which are the result of changes in the expression of certain genes within the brain. These changes in gene expression the brain are also thought to lay the foundation for addiction. The release of peptides (small proteins) in the brain may contribute to these changes in gene expression in the brain and subsequent behaviors. Information from this proposal could be used to develop anti-peptide compounds for the treatment of psychostimulant abuse and addiction.
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0.961 |