We are testing a new system for linking grants to scientists.
The funding information displayed below comes from the
NIH Research Portfolio Online Reporting Tools and the
NSF Award Database.
The grant data on this page is limited to grants awarded in the United States and is thus partial. It can nonetheless be used to understand how funding patterns influence mentorship networks and vice-versa, which has deep implications on how research is done.
You can help! If you notice any innacuracies, please
sign in and mark grants as correct or incorrect matches.
Sign in to see low-probability grants and correct any errors in linkage between grants and researchers.
High-probability grants
According to our matching algorithm, Karen N. Leung is the likely recipient of the following grants.
Years |
Recipients |
Code |
Title / Keywords |
Matching score |
2012 — 2013 |
Leung, Karen Nicole |
F32Activity Code Description: To provide postdoctoral research training to individuals to broaden their scientific background and extend their potential for research in specified health-related areas. |
High Resolution Imaging of Developmentally Regulated Epigenetic Alterations @ University of California, San Francisco
DESCRIPTION (provided by applicant): This proposal is aimed at developing tools and techniques to image single cells at high resolution and reveals the role of epigenetic machinery in chromatin architecture regulation in vivo. Epigenetically regulated changes in chromatin organization are a fundamental component of gene regulation. While a multitude of protein players and epigenetic marks are known, how each of these factors affects chromatin structure is not fully understood, particularly in the context of development. This proposal will examine two epigenetically regulated systems of mammalian chromatin organization, olfactory receptor gene choice and X chromosome inactivation, utilizing a novel, high resolution imaging technique, called soft X-Ray tomography (SXT). SXT allows examination of intact, unfixed and unstained cells to a resolution level similar to electron microscopy. This powerful imaging system, which captures native chromatin architecture, will be employed in combination with innovative labeling approaches and sophisticated genetic and epigenetic manipulations to reveal the molecular underpinnings of higher order chromatin architecture and the 3-dimensional organization of the mammalian nucleus. Because both olfactory gene choice and X-inactivation are examples of developmentally regulated epigenetic gene regulation that are experimentally tractable, this approach will provide significant understanding to the regulatory logic of these two essential processes. PUBLIC HEALTH RELEVANCE: Disruption of nuclear architecture is associated with human diseases and disorders ranging from progeria to Rett syndrome to cancer. Thus, understanding the structural principles of higher order chromatin packaging and the organizational logic by which chromatin is arranged in the 3-dimensional nuclear space is relevant to a variety of disease processes. This proposal will combine high resolution microscopy and manipulation of epigenetic machinery to dissect the spatial organization of the mammalian nucleus and to investigate the molecular mechanisms that regulate this organization.
|
0.984 |