We are testing a new system for linking grants to scientists.
The funding information displayed below comes from the
NIH Research Portfolio Online Reporting Tools and the
NSF Award Database.
The grant data on this page is limited to grants awarded in the United States and is thus partial. It can nonetheless be used to understand how funding patterns influence mentorship networks and vice-versa, which has deep implications on how research is done.
You can help! If you notice any innacuracies, please
sign in and mark grants as correct or incorrect matches.
Sign in to see low-probability grants and correct any errors in linkage between grants and researchers.
High-probability grants
According to our matching algorithm, Chern-Sing Goh is the likely recipient of the following grants.
Years |
Recipients |
Code |
Title / Keywords |
Matching score |
1999 — 2001 |
Goh, Chern-Sing |
P41Activity Code Description: Undocumented code - click on the grant title for more information. |
Analysis of Co Evolution of Ligand Receptor Binding Specificities: Hiv @ University of California San Francisco
Chemokines are small secretory or membrane bound proteins, approximately 120 amino acid residues, involved in chemotaxis of leukocyte subpopulations and specific induction of endothelial cell adhesion. They constitute a large family of chemotactic cytokines that act at G protein-coupled receptors to regulate diverse biological processes, including leukocyte trafficking, angiogenesis, and hematopoiesis. Recently, it was found that chemokines RANTES, MIP1a, MIP1b, and SDF-1 were potent inhibitors of HIV infection. The chemokine receptors of these chemokines, CCR5 and CXCR4 were shown to be the main co-receptors to CD4 in HIV infection. CCR5 and CD4 are coreceptors in monocyte/macrophage-tropic HIV strains and CXCR4 and CD4 are coreceptors in the lymphocyte-tropic HIV strains. Not only do chemokines play a role in HIV, but they also exert other biological effects in inflammatory conditions and in malignant tumors. Chemokines like PF4, IP10, and MIG are angiostatic and induce tumor regression by reducing the tumor blood supply. However, IL8, which is angiogenic, can promote tumor growth. These and other results suggest the potential therapeutic utility that chemokines have in the area of inflammation, cancer, and infectious disease. We are using structure and sequence analysis techniques in order to predict the ligand binding specificity of the chemokine receptors. In particular, we are focusing on three different issues: 1) analyze ligand-receptor binding contacts; 2) study structural motifs involved with binding; 3) study correlations in the way that ligands and their receptors co-evolve.
|
1 |
2003 — 2006 |
Goh, Chern-Sing |
F32Activity Code Description: To provide postdoctoral research training to individuals to broaden their scientific background and extend their potential for research in specified health-related areas. |
Mining the Structural Genomics Pipeline
DESCRIPTION (provided by applicant): Structural genomics is a major initiative that will revolutionize our understanding of protein structure and function, By analyzing the vast amount of information generated by the structural genomics consortia, it is possible to look for a correlation between a protein's sequence features and other genomic aspects to a its performance in these standardized experiments, Identifying a general set of protein features and analyzing their effect on a protein's ability to be structurally determined will allow for rapid identification of proteins that are amenable to structural determination, and ultimately, lead to optimization of high-throughput structure determination, Additionally, this set of protein features will be integrated into a general decision tree algorithm that can be used to predict a user-defined protein characteristic, such as solubility. By characterizing the protein properties that determine a protein's propensity to be structurally determined, it is possible to gain valuable information that can be utilized to develop algorithms that can engineer soluble proteins, which can lead to an increase in the amount and speed of protein structures determined.
|
0.97 |