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High-probability grants
According to our matching algorithm, Yoshiaki Kidokoro is the likely recipient of the following grants.
Years |
Recipients |
Code |
Title / Keywords |
Matching score |
1985 — 1986 |
Kidokoro, Yoshiaki |
N/AActivity Code Description: No activity code was retrieved: click on the grant title for more information |
Neuromuscular Junction Formation and Neurospecificity @ University of California-Los Angeles |
0.966 |
1986 — 1992 |
Kidokoro, Yoshiaki |
R01Activity Code Description: To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies. |
Muscle Differentiation and Synaptic Interaction @ University of California Los Angeles
This proposal will focus on the following three subjects: 1) Developmental changes in electrophysiological properties of Xenopus nerve and muscle cells in culture. 2) Synaptic interactions between mammalian clonal cell lines, and 3) Antibody against acetylcholine receptor as a probe for neurospecific interaction. Presynaptic and postsynaptic properties will be sytemmatically examined in Xenopus nerve-muscle cultures. Quantal nature of endplate potentials, spacial distribution of transmitter releasing sites along the length of nerve contact and susceptibility of presynaptic terminals against various treatments will be studied. Postsynaptically, properties of individual acetylcholine receptor (AChR) channels and electrical excitabilities are also planned to be studied. Effort to use clonal cell lines as a model for nerve-muscle interaction will be continued. A system in which both functional transmission and AChR accumulation occur will be searched. Monoclonal antibodies against AChRs will be used as a probe for nerve-muscle interaction. The effect of antibodies against various developmental steps will be examined. If recognition of AChRs were involved in some steps during development, the antibody may dissect out the molecular mechanism of the interaction.
|
0.966 |
1989 |
Kidokoro, Yoshiaki |
R01Activity Code Description: To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies. |
Microneurophysiology @ University of California Los Angeles
The common theme of the projects is the assessment of differentiation of electrical properties in different tissues in a variety of animals, and in different stages of development of the same animal. We divide the research plan into three categories. ANALYSIS OF CA CHANNEL. The permeability of the Ca channel will be examined by altering ions inside the cell. Questions are: i) Can divalent cations carry outward currents?, ii) How internal monovalent cations affect the reversal potential?, iii) Do divalent cations inside block the outward monovalent cation current as they do externally? It has been shown that different types of Ca channels exist. Are there any phylogenetical principles? We would like to study Ca channels in plant cells, the trap-lobe of Venus flytrap using protoplasts, which have no cell wall. We would also like to examine the expression of Ca channel by extracting mRNA of clonal lymphocyte cells which have Ca currents. STUDIES ON NEURONS IN MAMMALIAN CENTRAL NERVOUS SYSTEM. We would like to initiate this project with primary culture of rat cerebellar cortex. Ion channels, particularly non-inactivating Na channels and Ca channels, will be studied in Purkinje cells. Glutamate-aspartate type excitatory postsynaptic receptors will be classified in Purkinje cells. Properties of the granule-Purkinje cell synapse will be analysed. We would like to make co-cultures of Purkinje and granule cells with inferior olive cells to examine the interaction between these two types of excitatory inputs to the Purkinje cell. ELECTROPHYSIOLOGICAL APPROACHES TO IMMUNOLOGICAL PHENOMENA. Hybridomas secreting immunoglobulin (lg) have Ca channels. The significance of the Ca channel and its role in lg secretion is one aim of these studies. The other project is to study the ionic properties of the membrane during the maturation of human B lymphocyte, from small resting B lymphocytes into large non-proliferating blast cells, proliferating non-lg secreting blast and finally mature lg- secreting cells. Each of these cellular stages can be isolated by using appropriate lymphokines or reagents.
|
0.966 |