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High-probability grants
According to our matching algorithm, Adam Resnick is the likely recipient of the following grants.
Years |
Recipients |
Code |
Title / Keywords |
Matching score |
2008 — 2011 |
Resnick, Adam Cain |
K99Activity Code Description: To support the initial phase of a Career/Research Transition award program that provides 1-2 years of mentored support for highly motivated, advanced postdoctoral research scientists. R00Activity Code Description: To support the second phase of a Career/Research Transition award program that provides 1 -3 years of independent research support (R00) contingent on securing an independent research position. Award recipients will be expected to compete successfully for independent R01 support from the NIH during the R00 research transition award period. |
Regulation of Oncogenic Signal Transduction Pathways by Inositol Polyphosphates @ University of Pennsylvania
[unreadable] DESCRIPTION (provided by applicant): Project Summary: Aberrant regulation of inositide second messenger signaling or associated pathway components is one of the most prevalent abnormalities in human cancers with mutations altering phosphoinositide-3 kinase (PI3K) signaling representing the best documented alterations. Activating mutations or upregulation of upstream receptor tyrosine kinases, PI3K itself, or downstream targets such as AKT, as well as loss of function mutations of negative regulators including PTEN characterize a large number of tumors and occur frequently in some of the most common central nervous system tumors. The current application describes the characterization of a novel inositide signaling pathway comprised of the recently characterized inositol polyphosphate kinases (IPKs) and their regulation of cell growth and proliferation in human CNS cancers. Preliminary evidence suggests IPK signaling impinges upon canonical phosphoinositide signaling components including AKT. [unreadable] [unreadable] The proposed research seeks to delineate the molecular mechanisms of action of IPK signaling, define their functional significance in vivo utilizing conditional mouse knockouts, and test their potential targeting in human cancer model systems. The proposed research will be conducted at the Department of Neurosurgery at the Children's Hospital of Philadelphia and University of Pennsylvania where the candidate holds the position of instructor under the mentorship of Tom Curran. The candidate completed his Ph.D. training in the Solomon H. Snyder Department of Neuroscience at the Johns Hopkins Medical School under Solomon H. Snyder in 2005-2006. The award will support the candidate's transition into central nervous system cancer research while building on his accomplishments and discoveries in a relatively new field of cell signaling. [unreadable] [unreadable] Relevance: The proposed research addresses the contribution and potential targeting of a novel, recently characterized cell signaling pathway impinging on well characterized and oft occurring cancer-associated abnormalities, particularly in the central nervous system. In defining additional regulators of the cancerous state a multitargeted approach towards cancer can be implemented in cancers refractory to monotherapies. [unreadable] [unreadable] [unreadable]
|
0.958 |
2013 — 2018 |
Resnick, Adam |
N/AActivity Code Description: No activity code was retrieved: click on the grant title for more information |
Career:Discovery and Characterization of Inositol Polyphosphates as Mediators of Protein Pyrophosphorylation @ The Children's Hospital of Philadelphia
Intellectual Merit Nearly every aspect of cell biology depends on small molecule messengers that function to communicate and integrate information about the cellular environment, growth conditions, and available nutrients; and also relay information between neighboring cells. This project aims to discover and define the second messenger roles of inositol pyrophosphates, a novel and ubiquitous, yet poorly characterized class of high-energy molecules. To date, every eukaryotic organism examined has been found to contain inositol pyrophosphates, from unicellular organisms, to plants, to man. Why cells expend energy synthesizing these molecules or what precise mechanistic roles they have in biology has remained largely unexplored. Previously, inositol pyrophosphates have been implicated in diverse cellular processes ranging from the maintenance of DNA integrity to regulating available cellular energy pools. Using newly developed methodologies that overcome challenges that have stymied this young and underdeveloped research field, this project seeks to define the wide-reaching biological roles and unique signaling capacity of the inositol pyrophosphates. More specifically, these high energy molecules have been shown to be capable of modifying cellular proteins by transferring an energetic phosphate to protein substrates, an event that generates a novel modification termed protein pyrophosphorylation. Through new experimental modalities hundreds of proteins that span the breadth of eukaryotic organisms have been found to be pyrophosphorylated. This project will begin the process of defining the roles of protein pyrophosphorylation by focusing on, and examining how inositol pyrophosphates affect the function of these proteins. The project's ultimate endpoints are (1) the description of a new and expansive signaling system and (2) the construction of an open experimental framework for its investigation in diverse biological contexts.
Broader Impacts The educational activities associated with the project purposefully juxtapose and reinforce basic, fundamental research activities alongside established translational research curricula in a context that spans all levels of education. They specifically focus on the training of students in traditional physician-scientist preparatory programs in order to provide fundamental, basic research opportunities and experiences, as well as support an authentic understanding of the critical and necessary roles of basic research. The educational programs will provide research opportunities to students as part of a diverse environment and focus in particular on outreach and basic research training of high school, undergraduate, and medical school students with programmatic efforts directed at the inclusion of under-represented minorities and women.
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0.91 |