1987 — 1988 |
Ritchie, James C [⬀] |
R01Activity Code Description: To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies. |
Studies of Plasma Dexamethasone Levels and the Dst
diagnostic tests; dexamethasone;
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0.97 |
1999 — 2011 |
Ritchie, James Carl [⬀] |
P50Activity Code Description: To support any part of the full range of research and development from very basic to clinical; may involve ancillary supportive activities such as protracted patient care necessary to the primary research or R&D effort. The spectrum of activities comprises a multidisciplinary attack on a specific disease entity or biomedical problem area. These grants differ from program project grants in that they are usually developed in response to an announcement of the programmatic needs of an Institute or Division and subsequently receive continuous attention from its staff. Centers may also serve as regional or national resources for special research purposes. |
Core--Assay
CORE C - ABSTRACT The purpose of the Assay Core (Core C) is to provide a common set of state-of-the-art biochemical analyses to Center researchers. The Core laboratory will provide assessments of markers of hypothalamicpituitary- adrenal axis function, neurotransmitter (central and peripheral) and drug levels for center subjects. Accurate measurement of these parameters is imperative to characterize each of the indices of early life stress, development, and their neurobiological consequences being investigated by the Center's animal and human projects. Having these determinations performed in a central facility using a common set of assay modalities will provide the unprecedented opportunity to compare these models across species (without introducing the variable of assay incompatibilities). Additionally, having a Core devoted to these analyses will guarantee high quality assay performance, allow for economies-of-scale in the purchase of assay reagents and technician time, and enable Center investigators to more fully concentrate their efforts on the unique aspects of their particular project. For Project 1, the Assay Core will provide measures of HPA axis activity, medication levels, salivary amylase & cortisol, and surveillance for substance abuse (smoking, alcohol, screening for drugs of abuse). For Project 2, the Assay Core will provide these same measures as well as measures of CRF (total and free) and CRF binding protein. This last assay will be developed by the Assay Core especially for this project. For Project 3, we will provide similar measures on the children of subjects who participate in Project 1. Measures of salivary cortisol and amylase on young children, especially infants, can be problematic. We have much experience working with Dr. Goodman's group as part of the Emory Conte Center, in obtaining these precious samples. For Project 4, we will provide measures of HPA axis activity as well as medication levels in rats. All of the data, obtained from a common set of assays, will be stored in the Assay Core's laboratory database as well as the Center's centralized WMHP relational database (refer to Core A for additional description) to be readily available to all Center investigators.
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1 |
2000 — 2004 |
Ritchie, James C [⬀] |
R01Activity Code Description: To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies. |
Hpa Axis Regulation and Ectopeptidase Action
hypothalamic pituitary adrenal axis; exopeptidase; peptide hormone metabolism; corticotropin releasing factor; enzyme activity; glucocorticoids; tissue /cell culture; laboratory rat; histology;
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1 |
2004 — 2008 |
Ritchie, James Carl [⬀] |
P50Activity Code Description: To support any part of the full range of research and development from very basic to clinical; may involve ancillary supportive activities such as protracted patient care necessary to the primary research or R&D effort. The spectrum of activities comprises a multidisciplinary attack on a specific disease entity or biomedical problem area. These grants differ from program project grants in that they are usually developed in response to an announcement of the programmatic needs of an Institute or Division and subsequently receive continuous attention from its staff. Centers may also serve as regional or national resources for special research purposes. |
Assay Core
The purpose of this Core is to provide a common set of state-of-the-art biochemical analyses to Center researchers. The laboratories of the Core will provide assessments of hypothalamic-pituitary-adrenal axis function, thyroid axis function, gonadal hormones, neurotransmitter (central and peripheral) levels, and antidepressant concentrations to the individual research projects of the Emory University Center for the Neuroscience of Mental Disorders. Accurate measurement of these parameters is imperative to fully characterize each of the preclinical and clinical model systems of early life stress and its long-term neurobiological consequences in adults being investigated by the Center. Having these determinations performed by a central facility using a common set of assay modalities will provide the unprecedented opportunity to compare these models across strain and species lines (without introducing the variable of assay incompatibilities). Additionally, having a Core devoted to these analyses will guarantee high quality assay performance, allow for economies-of-scale in the purchase of assay reagents and technician time, and enable Center investigators to more fully concentrate their efforts on the unique aspects of their particular project.
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1 |
2009 — 2013 |
Ritchie, James Carl [⬀] |
P50Activity Code Description: To support any part of the full range of research and development from very basic to clinical; may involve ancillary supportive activities such as protracted patient care necessary to the primary research or R&D effort. The spectrum of activities comprises a multidisciplinary attack on a specific disease entity or biomedical problem area. These grants differ from program project grants in that they are usually developed in response to an announcement of the programmatic needs of an Institute or Division and subsequently receive continuous attention from its staff. Centers may also serve as regional or national resources for special research purposes. |
Core D: Assay Core @ University of Minnesota
The focus of this Center is to understand the impacts of early life stress (ELS). In this context, we understand ELS to include adverse early care conditions, deprivation, separation, neglect, and abuse. This Center will attempt to integrate basic developmental behavioral neuroscience models (primate and human) to increase the understanding of the impact of ELS (behavioral & neurobiological), to identify care models that promote recovery, to determine if the capacity for recovery decreases with age, and to approach these problems via preventive intervention researchers in the hope that future interventions can benefit from a more comprehensive knowledge base. The Laboratory Core will provide a common set of state-of-the-art biochemical analyses to support all research projects and other Cores in the Center. The biochemical Assay Core Laboratory is located within the Department of Pathology & Laboratory Medicine, at the Emory University School of Medicine. The purpose of the Assay Core (Core D) is to provide a common set of state-of-the-art biochemical and genetic analyses to Center researchers. The Core laboratory will provide assessments of hypothalamic- pituitary-adrenal axis function and neurotransmitter (central and peripheral) levels for the NIMH Early Experience, Stress and Neurobehavioral Development Center. Accurate measurement of these parameters is imperative to fully characterize each of the animal and human projects of early life stress and its neurobiological consequences being investigated by the Center. Having these determinations performed by a central facility using a common set of assay modalities will provide the unprecedented opportunity to compare these models across species (without introducing the variable of assay incompatibilities). Additionally, having a Core devoted to these analyses will guarantee high quality assay performance, allow for economies-of-scale in the purchase of assay reagents and technician time, and enable Center investigators to more fully concentrate their efforts on the unique aspects of their particular project. This Core will also participate in the cross-training program of the Center in basic neuroscience and developmental neuroendocrinology. RELEVANCE (See instructions): This Core will provide a set of state-of-the-art biochemical analyses to Center researchers, effectively reducing the possibility of assay incompatibilities, guaranteeing high quality assay performance, and improving efficiency. The Core will also participate in the cross-training program of the Center in basic neuroscience and developmental neuroendocrinology.
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0.966 |