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High-probability grants
According to our matching algorithm, Michelle M. Ostrander is the likely recipient of the following grants.
Years |
Recipients |
Code |
Title / Keywords |
Matching score |
1998 — 2000 |
Ostrander, Michelle M |
F31Activity Code Description: To provide predoctoral individuals with supervised research training in specified health and health-related areas leading toward the research degree (e.g., Ph.D.). |
Environmental Modulation of Drug Induced Ieg Expression @ University of Michigan At Ann Arbor
DESCRIPTION: (Applicant's Abstract) Previous research from this laboratory has demonstrated that the environmental circumstances surrounding amphetamine administration can powerfully modulate both its acute psychomotor activating effects and the ability of repeated amphetamine to induce behavioral sensitization. The purpose of the experiments described in this proposal is to examine, using immediate early gene expression as a marker of neuronal activity, the neural systems involved in the environmental modulation of both the acute and repeated effects of amphetamine. Specifically, we hypothesize that 1) the neural circuitry engaged by acute amphetamine will vary as a function of the environment in which it is administered, 2) the neural circuitry engaged by amphetamine will change as a function of prior drug history and the development of sensitization, and these neuroadaptations will vary as a function of the environment in which drug is administered, and 3) that mere exposure to contextual stimuli associated with prior drug administration will engage similar neural circuitry as that engaged by exposure to the drug itself. These experiments will provide important new insights into how the neurobiological actions of amphetamine are modulated by the environmental circumstances surrounding its administration.
|
1 |
2003 — 2005 |
Ostrander, Michelle M |
F32Activity Code Description: To provide postdoctoral research training to individuals to broaden their scientific background and extend their potential for research in specified health-related areas. |
Glucocorticoid Receptors and Behavioral Sensitization @ University of Cincinnati
[unreadable] DESCRIPTION (provided by applicant): [unreadable] Stress is believed to play a critical role in the vulnerability and relapse to addiction. Behavioral sensitization to psychostimulant drugs is an enduring form of neural plasticity in limbic brain regions clearly implicated in addiction, and is defined as an increase in drug effect with repeated drug or stress exposure. Previous studies suggest that an intact hypothalamic-pituitary-adrenal axis is important for the development of drug- and stress-induced sensitization, but little is known about the molecular and anatomical targets at which adrenal stress hormones act to mediate this process. The medial prefrontal cortex contains high levels of glucocorticoid receptors and lesions of this area disrupt drug-induced sensitization, suggesting a role for glucocorticoid receptors of this region in behavioral sensitization. In this application, I hypothesize that activation of glucocorticoid receptors in the medial prefrontal cortex contributes to the development of behavioral sensitization. The goals of this proposal are to: 1) elucidate the role of medial prefrontal cortex glucocorticoid receptors in drug- and stress-induced sensitization through antagonist studies and 2) determine if glucocorticoid receptor activation in the medial prefrontal cortex will facilitate the development of sensitization to psychostimulant drugs. [unreadable] [unreadable] [unreadable] [unreadable]
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0.955 |