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High-probability grants
According to our matching algorithm, Margaret A. Naeser is the likely recipient of the following grants.
Years |
Recipients |
Code |
Title / Keywords |
Matching score |
1992 — 2001 |
Naeser, Margaret A |
P50Activity Code Description: To support any part of the full range of research and development from very basic to clinical; may involve ancillary supportive activities such as protracted patient care necessary to the primary research or R&D effort. The spectrum of activities comprises a multidisciplinary attack on a specific disease entity or biomedical problem area. These grants differ from program project grants in that they are usually developed in response to an announcement of the programmatic needs of an Institute or Division and subsequently receive continuous attention from its staff. Centers may also serve as regional or national resources for special research purposes. |
Core--Neuroimaging Resources @ Boston University Medical Campus
This Core provides for CT scan and MRI scan lesion information on all patients processed through the Boston VA Medical Center, Neuroimaging films on all patients are processed to provide diagrams of lesion outlines, slice by slice, along with tabulation of structures affected, using a neuroanatomical checklist. Hemisphere asymmetry measurements are also determined in all cases, for use in studies where this factor needs to be taken into account. These data are presented at Aphasia Grand Rounds, and distributed in hard copy form, and kept on file for later access, for either retrospective studies or for use when a former patient is bought back for research purposes.
|
0.928 |
2002 — 2010 |
Naeser, Margaret A |
R01Activity Code Description: To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies. |
Transcranial Magnetic Stimulation to Improve Speech @ Boston University Medical Campus
DESCRIPTION (provided by applicant): The purpose of this research is to investigate whether repetitive transcranial magnetic stimulation (rTMS) can be used to improve speech in chronic stroke patients with nonfluent aphasia. rTMS allows non-invasive stimulation of human cortex. Slow (1 Hz) rTMS appears to decrease excitability in the targeted cortical region of interest (ROI) leading to measurable behavioral effects. A small 8-shaped coil (as will be used in the present study) affects primarily a cortical area of less than 2 x 2 cm. We have observed in fMRI studies that patients with nonfluent speech (slow, hesitant, poorly articulated, agranunatic speech) have excess blood flow (presumed abnormal increase in cortical excitability) in many right (R) perisylvian areas including R sensorimotor mouth, R Broca's homologue (BA 45) and R Wernicke's homologue(BA 22). Slow (1 Hz) rTMS will be used to suppress activation of specific ROls observed to have high blood flow (presumed overactivation) on fMRI. It is expected that suppression of activity in the directly targeted ROl will have an overall modulating effect on functionally connected elements of the distributed neural network for naming (and propositional speech) in chronic stroke patients with nonfluent aphasia, and will result in a behavioral improvement. Pilot data on four nonfluent aphasia patients support this claim and document the feasibility and safety of the study. Naming Ability (20 pictures of common objects) and reaction times are measured immediately pre- and immediately post- an rTMS treatment. There are two phases. Phase 1 includes aphasia patients (n=40) and age-matched normal controls (n=12). For normal controls, Phase 1 will provide information on the effect of slow rTMS on 7 language-related ROIs. For aphasia patients, Phase 1 will provide information regarding which of 5 ROIs is the most promising for more extensive rTMS treatment in Phase 2. Phase 2 (aphasia patients only) is a randomized, sham-controlled, incomplete crossover design. One group (n=20) receives 10 Real rTMS treatments over a two-week period; and one group (n=20), 10 Sham rTMS treatments over a two-week period. Only those who receive Sham treatments FIRST will be crossed over. It is hypothesized that 10 sessions of Real rTMS at 1 Hz given over a two week period to a specific ROl (e.g., R BA 45, supported from our pilot data) will significantly improve picture naming and propositional speech, when tested at 1-2 weeks and 2 months post- the last rTMS treatment, as compared to pre- Phase 2 testing. Sham rTMS to the same ROl is hypothesized to have no effect. This will be the first systematic rTMS study designed to improve speech in stroke patients with nonfluent aphasia. The implications could be far reaching regarding optimal treatment in aphasia with potential for combining current language therapies with rTMS to promote maximum recovery of language.
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0.928 |