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High-probability grants
According to our matching algorithm, Howard Moltz is the likely recipient of the following grants.
Years |
Recipients |
Code |
Title / Keywords |
Matching score |
1985 |
Moltz, Howard |
R01Activity Code Description: To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies. |
Physiochemical Control of Reproductive Behavior
During the past 12 years my laboratory has been concerned with proximate mechanism underlying the synthesis of a pheromone that appears in the feces of maternally-behaving rats. Now that we have identified many of these mechanisms and can characterize the pheromone in general molecular terms, we shall ask why preweanling young approach the pheromone and consume pheromone-containing feces. We think that in doing so they gain two advantages, one relating to the gut and the other to the brain. Our hypothesis is that "pheromone feces" are rich in deoxycholic acid and that the ingestion of this secondary bile acid guards the pup against enteric infection and promotes the absorption of long-chain fatty acids for use centrally in myelination. The methodology we shall employ is that of Biopsychology and Biochemistry. If the experiments we intend to carry out prove successful, then we will have increased our understanding not only of gut maturation but of brain maturation as well. This in turn may offer clues for the treatment of selected enteric and dysmyelinating diseases.
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1 |
1987 — 1989 |
Moltz, Howard |
N/AActivity Code Description: No activity code was retrieved: click on the grant title for more information |
Thermoregulation and Reproduction
There are specific areas of the brain that are known to regulate a number of bodily functions. One such area is the medial preoptic area (MPOA) of the hypothalamus. In the male rat, this brain area has been shown to monitor body temperature and allow response of the body to changes in environmental temperature. In addition, the MPOA processes sensory information and, in the presence of testosterone, this area mediates hormonal and behavioral aspects of reproduction. Given this duality of function within the MPOA, experiments were begun to investigate a relationship of temperature, both in the body and in the MPOA, reproductive function. Using sophisticated telemetric thermosensors, the MPOA and deep body temperature in male rats will be monitored relative to physiological and reproductive status. Preliminary data have shown that there are changes in MPOA temperature independent of changes in body temperature, but related to reproductive processes. Further, rapid and selected cooling of the MPOA was not related to general changes in body temperature related to exercise. The experiments will examine this phenomena in more detail. The information gathered in this research will be of great interest in terms of technological developments of instruments used in the research. In addition, the study of the duality in function of the MPOA will elucidate some of mechanisms involved in the regulation of temperature and reproductive function.
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1 |