Jonathan R. Cole - US grants

health science research support; university;

The Morningside Campus of Columbia University, located at Broadway and 116th Street, includes, among others, the faculties of Columbia College and the Graduate School of Arts and Sciences. It is a geographically separate entity from the Columbia College of Physicians and Surgeons and is covered by a separate assurance. At the Morningside Campus, animals are used in both basic biomedical research and in graduate and undergraduate instruction. The Morningside Animal Facility is housed in the Fairchild and Schermerhorn Buildings, which are connected by internal corridors, and administers, houses, maintains, and cares for these animals, which include rodents, lagomorphs, pigeons, amphibians, and invertebrates. This Facility requires modernization and reorganization if it is to furnish animal care of the highest quality for the University's current and future needs. In response to this, the University has recently developed a comprehensive plan, of which this grant proposal is only a part, to improve the Morningside Animal Facility so that it meets and exceeds the latest standards for animal care and use set by the NIH and other granting and regulatory organizations. Having done so, we will seek accreditation by American Association Accreditation of Laboratory Animal Care. The University's objectives are to provide (1) an efficient and centralized administration of our Animal Facility, (2) a physical plant for the Animal Facility that conforms to the requirements of the 1985 NIH Guide for the Care and Use of Laboratory Animals, (3) expert care of our animal colonies, and comprehensive instruction for all personnel who handle animals, (4) adequate animal husbandry equipment, and (5) a modern surgery. This proposal requests partial support for these objectives. The remainder of the costs will be provided by the University. The organizational and procedural changes called for by our plan have begun. The construction of new animal housing rooms and improvement of the air conditioning in the Facility began during April, 1986. We plan to have all aspects of our new Facility completed by August, 1987. This, in conjunction with our new administrative structure and animal husbandry program, should insure that biomedical research and training at the Morningside Campus will exceed the standards for animal care and use stipulated in the 1985 NIH Guide and that Columbia University will maintain and advance its pre-eminent role in research and education.

biomedical equipment purchase; nucleic acid probes;

This Academic Research Facilities Modernization Program (ARFMP) award from the Research Facilities Office provides funds to Columbia University for the renovation and repair of the William S. Black Research Building of the College of Physicians & Surgeons, which after the modernization, will house structural studies, a multi-disciplinary research and research training program in molecular biophysics. This building was constructed in 1965 and has not previously been renovated. The ARFMP grant of $700,000 and $903,000 provided by the grantee as cost sharing will be used to modernize these research and research training facilities. It will make possible new research capabilities and collaborative interaction not possible under current conditions. This project will address the need to improve the current research infrastructure by conversion of research and research training space so as to permit consolidation of related work in structural biology and by upgrading the heating, ventilation, and air conditioning (HVAC) so that it is suitable to meet the demands of x-ray diffraction and of the computer facilities. This award contributes to the infrastructure of science by providing an improved environment for the conduct of research and for the training of quality undergraduate, graduate, and postdoctoral students and for fostering academic-industrial ties. Students trained in these laboratories will be able to serve as models for the feasibility of the training of computer-literate molecular biologists.

This is an award under the Grants for Improving Doctoral Dissertation Research Program. The research examines the factors that contribute to the formation of the Chinese scientific elite. The study uses a comparative perspective for assessing applicability to the Chinese context of theories about Western scientific knowledge . A variety of data are used, including biographies, mail surveys, interviews with scientists, and documentary and archival sources. %%% This research will contribute to the sociological understanding of science, Chinese society, and comparative science policies. In addition to the scientific gains to be achieved by the research, this award will materially assist a highly promising student in completing research for the Ph.D. dissertation. It contributes to international understanding and the thorough training of the next generation of social scientists.