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High-probability grants
According to our matching algorithm, Joel M. Levine is the likely recipient of the following grants.
Years |
Recipients |
Code |
Title / Keywords |
Matching score |
1985 — 2007 |
Levine, Joel M |
R01Activity Code Description: To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies. |
Cell Surface Molecules of the Developing Nervous System @ State University New York Stony Brook
Despite a wealth of descriptive and experimental information, little is known about the mechanisms responsible for the early differentiation and development of the mammalian central nervous system. In particular, the developmental lineages that give rise to the diversity of morphological and biochemical phenotypes found in the mature nervous system are poorly understood. Recently, a monoclonal antibody raised against the B49 cell line has identified a cell surface ganglioside antigen specifically found on germinal cells within the CNS. This antigen, designated as Dl.l, has been found on the surfaces of neuroepithelial cells, the stem cells of the CNS but it is not detected on the differentiated progeny of these cells. The derivation of the anti-Dl.l antibody and the identification of the antigen provide an opportunity to analyze the early development of the CNS at the cellular and biochemical level. The specific aims of the proposal are to 1) define the chemical structure of the Dl.l ganglioside antigen and identify the biochemical mechanisms responsible for its expression on germinal cells and for its subsequent loss or disappearance during neuronal and glial differentiation, 2) map the complete tissue and cellular distribution of the antigen during embryogenesis to determine whether the antigen may be a marker for stem cells that can give rise to some but not all neuroectodermally derived cell types, 3) test the functional role of the Dl.l ganglioside incell-cell and cell-substrate adhesion and in growth control, 4) analyze the expression of cell surface and intracellular markers characteristic of mature neurons and glial cells by Dl.l positive germinal cells and 5) isolate CNS germinal cells by fluorescence activated cell sorting and analyze their capacity to differentite in vitro. In addition, isolated terminal cells will be microinjected into post-natal and adult brain to determine whether germinal cells differentiate according to their origin or according to their new environment. The proposed studies should lead to an understanding of the cellular basis of neuronal and glial differetiation and to an evaluation of the functional role of the Dl.l ganlioside in the processes of development.
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1 |
2012 — 2013 |
Ge, Shaoyu (co-PI) [⬀] Levine, Joel M |
R21Activity Code Description: To encourage the development of new research activities in categorical program areas. (Support generally is restricted in level of support and in time.) |
Viral Tools For Studying Ng2 Cells @ State University New York Stony Brook
DESCRIPTION (provided by applicant): Oligodendrocytes, the myelin forming cells of the CNS, develop from identified precursor cells known alternately as oligodendrocyte progenitor cells (OPCs), polydendrocytes, or NG2 cells. These cells appear about midgestation in rodents at specific locations within the developing CNS, migrate extensively, proliferate as they migrate, and then slowly differentiate into myelin-forming cells. Surprisingly, a large fraction of the OPC population fails to fully differentiate and persists throughout the adult CNS as a slowly dividing cell that can be considered an fourth glial cell type. The functions of these adult OPCs are not well understood, in part, because of their unusual mixture of glial and neuronal properties. Major questions remain regarding 1) the phenotypic plasticity of these cells in developing and adult animals and after injury and 2) the role of electrical excitability in OPC development and function. The goal of this proposal is to develop new viral-based tools for analyzing the development and properties of NG2+ OPCs. Our strategy takes advantage of the availability of cell-type specific inducible cre mouse driver lines and recently developed flip vectors in which tandem mutant loxP sites allow for inversion of selected genes from an anti-sense to sense orientation. This strategy allows for temporal control of the expression of marker antigens, functional proteins and RNAi. The tools to be developed here can be used widely to study other glial cell types within the central and peripheral nervous system. PUBLIC HEALTH RELEVANCE: Oligodendrocytes, the myelin-forming cells of the CNS, develop from an identified precursor cell that has an unusual mixture of neuronal and glial properties. Their functional role(s) in CNS homeostasis is unknown. The new tools to be developed here will help us to understand the unusual properties of these cells and how those properties relate to the responses of these cells to injury and demyelination.
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