Grayson Holmbeck - US grants

[unreadable] DESCRIPTION (provided by applicant): The purpose of this longitudinal study is to evaluate a developmentally-oriented bio-neuropsychosocial model of psychological adjustment in young adolescents with spina bifida (10-13 years old at Time 1 and 12-15 years old at Time 2). Extensive multi-source and multi-method data will be collected across several predictor variable domains: (1) biological, (2) neuropsychological, and (3) social. A multidimensional perspective on adolescent adjustment will also be adopted, with a rigorous focus on the adolescents' social adjustment. The proposed study will be the first to collect observed peer, interaction data (target child with close friend) in adolescents with spina bifida. The degree to which neuropsychological limitations experienced by children with spina bifida contribute to their social difficulties and other psychological problems will also be examined. Participants will include a sample of 140 children and young adolescents with spina bifida (with meningomyelocele and shunted hydrocephalus) along with their parents, a close friend, teachers, and health professionals. Spanish-speaking Hispanic/Latino families will also be recruited. Questionnaire, interview, neuropsychological testing, and observational methods will be employed during two home visits at Time 1 and two home visits at Time 2. In addition to evaluating the utility of the bioneuropsychosocial model, several mediational and moderational models will also be tested within the context of the more general model. Such models will facilitate identification of underlying mechanisms for associations between variables (i.e., mediational models) and will attempt to isolate variables within one domain that compensate for deficits in another domain (i.e., moderational models). Findings of this study will provide information on the differential relevance of family relationships, peer relationships, neuropsychological factors, and biological factors for adjustment in adolescents with spina bifida. Moreover, the results will have implications for prevention and intervention efforts with families who have offspring with disabling birth defects. [unreadable] [unreadable]

Project Summary Spina bifida (SB) is a congenital birth defect that has multi-systemic effects on physical, neurocognitive, psychological, and social functioning and requires affected individuals to manage and adhere to a complex medical regimen, while at the same time managing a unique array of cognitive and psychosocial comorbidities. Nonadherence in this population can result in costly, life-threatening health complications (e.g., pressure ulcers, acute renal failure), but has received little attention in the research literature. The goal of this project is to identify targets for self-management, adherence, and health care transition interventions for youth with SB, which can eventually be applied to other pediatric populations, especially those with serious CNS conditions (e.g., CP, epilepsy). This study represents a significant new addition to the Chicago Healthy Adolescent Transition Study (CHATS) and has the following aims: (1) to test the utility of an innovative longitudinal conceptual model of medical self-management and adherence during the adolescent and late adolescent developmental periods, and (2) to identify how critical self-management constructs (e.g., the transfer of medical responsibility from parent to child) are linked with the successful transition from pediatric to adult health care settings. The current study builds on a study that began in 2006 when the participants were ages 8-15 years. Funding of this proposal would enable this research team to: (1) complete longitudinal data collection (Time 5) on the self-management and medical adherence of adolescents and emerging adults with SB (ages 16-23 years) in the context of past and present biological, neuropsychological, social, and psychological functioning, and (2) begin data collection (Time 6) on the transition to adult health care when the entire sample reaches emerging adulthood (ages 18-25 years). This study utilizes a developmentally-oriented, longitudinal model of medical adherence and self-management based on prior models focused on other pediatric populations. Evaluation of the model will be accomplished with multi-method, multi-informant research methods, including daily phone diaries, observed family and peer interactions, audio-recorded interviews, neuropsychological tests, medical chart reviews, and questionnaire measures completed by mothers, fathers, youth, peers, teachers, and medical providers, as well as a comprehensive assessment of health complications. Theory-driven, innovative analyses will be possible with multiple longitudinal data points, including the following: (1) longitudinal tests of moderated meditation models including early individual and environmental self-management factors (Times 1-4), modifiable self-management mediators and moderators (Time 5), and changes in adherence and health complications (Times 5-6), and (2) investigation of associations between successful self-management and the successful transition to adult health care, as mediated by individuals' readiness for the transition to adult care. Based on the findings of this research, future grant proposals will test the feasibility and efficacy of a two-pronged intervention that will include a self- management/ adherence intervention as well as a clinic-based intervention to facilitate the transition to adult health care. Moreover, findings will support the development and dissemination of clinical guidelines for parents and health professionals, with a focus on self-management skills and the transition from pediatric to adult health care settings.