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High-probability grants
According to our matching algorithm, Kara L. Agster is the likely recipient of the following grants.
Years |
Recipients |
Code |
Title / Keywords |
Matching score |
2005 — 2006 |
Agster, Kara L |
F31Activity Code Description: To provide predoctoral individuals with supervised research training in specified health and health-related areas leading toward the research degree (e.g., Ph.D.). |
Postrhinal Cortex and Attentional Functions
DESCRIPTION (provided by applicant): The link between memory and attention has long been recognized; however, the precise signal that serves to select stimuli for further mnemonic processing has yet to be identified. Since attention can be rapidly oriented from one stimulus to another, the signal that initiates subsequent mnemonic processing must be closely tied to the events within conscious attention at all times to ensure that storage is properly aligned with content (Posner, 1984). Postrhinal cortex, the rodent homologue of the primate parahippocampal cortex, has diffuse anatomical connections with neural regions associated with memory and attention systems (Burwell and Amaral, 1998b). This places postrhinal cortex in an ideal position to interface these two systems. Additionally, current behavioral and electrophysiological data suggest that postrhinal cortex has a role in the orienting of attention (Bucci and Burwell, in press; Burwell and Hafeman, 2003). The goal of the proposed study is to delineate the afferent connectivity of postrhinal cortex and characterize the behavioral significance of this region's role in cognitive processing using single unit recording techniques in behaving rats.
|
1 |
2009 — 2010 |
Agster, Kara L |
F32Activity Code Description: To provide postdoctoral research training to individuals to broaden their scientific background and extend their potential for research in specified health-related areas. |
Methylphenidate, Vigilance, and Visual Perception
DESCRIPTION (provided by applicant): Attention deficit, hyperactivity disorder (ADHD) is one of the most frequently diagnosed disorders in children, adolescents, and adults. Characteristic symptoms of ADHD include increased motor activity levels, impulsivity, and attentional impairments. Inappropriate processing of sensory and environmental stimuli contributes to the observed deficits in impulsivity and attention. These deficits could occur in cortical or subcortical circuits along primary sensory pathways. Amphetamine-like stimulants, such as methylphenidate (MPH, Ritalin), are the primary treatments for ADHD. These medications are effective;however, patients do experience unwanted side effects. In order to more beneficially manage ADHD, more information regarding the underlying mechanisms of the disorder is needed. Methylphenidate has been shown to increase the level of available norepinephrine and dopamine in the brain. At low doses, however, MPH acts primarily to inhibit the reuptake of norepinephrine with little effect on dopamine transmission. Clinically relevant doses of MPH are in the range of acting principally on the noradrenergic system. The goal of the proposed experiments is to examine the effect of MPH and vigilance on sensory signal processing in the lateral geniculate nucleus through the use of single- and multi- unit recording techniques. Aims 1 and 2 investigate the effect of MPH on neuronal response to visual stimuli in the anesthetized state. A series of adrenergic antagonists will be administered in conjunction with MPH to determine whether alpha or beta NE receptors contribute to observed changes in neuronal activity. Aim 3 uses microdialysis to directly measure the changes in NE and DA efflux in the dorsal lateral geniculate nucleus during sensory stimulation and MPH administration. Aim 4 examines the effect of vigilance on neuronal activity in the lateral geniculate of the awake, behaving animal. The results of these studies will contribute to our understanding of the role of norepinephrine in perception, as well as how changes in sensory signal processing affect behavioral performance.
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0.966 |