Area:
Neurobiology Biology
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High-probability grants
According to our matching algorithm, Tou Y. Vue is the likely recipient of the following grants.
Years |
Recipients |
Code |
Title / Keywords |
Matching score |
2012 — 2014 |
Vue, Tou Yia |
F32Activity Code Description: To provide postdoctoral research training to individuals to broaden their scientific background and extend their potential for research in specified health-related areas. |
Role of Ascl1 in Glioma @ Ut Southwestern Medical Center
DESCRIPTION (provided by applicant): Primary malignant gliomas are incurable brain tumors that affect thousands of people every year. Although alteration of oncogenes and tumor suppressors genes have been described to contribute to the pathogenesis of gliomas, very little is known about the biology of glioma development or the genetic mechanisms that are essential for tumor formation and progression. Ascl1, a basic-helix-loop-helix (bHLH) transcription factor, is aberrantly upregulated in a number of cancers, including lung cancers with neuroendocrine features and malignant astrocytoma. Mouse models of malignant astrocytoma recently indicated that neural progenitors may be the cells of origin for glioma. Given that Ascl1 is expressed in neural progenitors during development as well as in the adult brain, and was recently shown to directly regulate cell cycle regulators, it is hypothesized that Ascl1 plays an important role in gliomagenesis. Preliminary evidence for the proposed project demonstrates that Ascl1 is highly expressed in a subset of cells of an early stage brain tumor and in cells at the periphery of a terminal stage brain tumor of a mouse model of malignant astrocytoma. The aims of the proposed project include genetic strategies to induce and directly visualize tumor development in the brains of mice, immunohistochemistry to describe the expression of Ascl1 in tumors at multiple stages of development, and use of fluorescence activated cell sorting (FACS) to isolate and characterize the tumorigenic properties of Ascl1-expressing tumor cells in vitro and in vivo. Finally, the requirement for Ascl1 for tumor formation and progression in this mouse model of glioma will be directly tested by conditional deletion of Ascl1. The culmination of this study will provide new insights into the heterogeneity and molecular mechanisms of glioma tumors.
|
0.919 |
2015 — 2019 |
Vue, Tou Yia |
K22Activity Code Description: To provide support to outstanding newly trained basic or clinical investigators to develop their independent research skills through a two phase program; an initial period involving and intramural appointment at the NIH and a final period of support at an extramural institution. The award is intended to facilitate the establishment of a record of independent research by the investigator in order to sustain or promote a successful research career. |
Underlying Molecular Mechanisms of Gliogenesis and Gliomagenesis in the Central Nervous System @ Ut Southwestern Medical Center
? DESCRIPTION (provided by applicant): Glia, which constitutes astrocytes and oligodendrocytes, are the most proliferative and abundant cell types in the central nervous system. Abnormal development of astrocytes and oligodendrocytes is associated with a number of neurological diseases and disorders such as amyolateral sclerosis (ALS), multiple sclerosis (MS), autism, epilepsy, schizophrenia, and glioblastoma, the deadliest of brain cancers. The basic-helix-loop-helix (bHLH) transcription factors Ascl1 and Olig2 are crucial for the specification and development of both astrocytes and oligodendrocytes, and are highly expressed in glioblastoma. The proposed project aims to: 1) determine the role and function of Ascl1 and Olig2 in regulating the generation of astrocytes and oligodendrocytes in the gray matter and white matter in the spinal cord; 2) determine the in vivo requirement of Ascl1 and Olig2 in brain tumors of a mouse model of glioblastoma; and 3) utilize Next-Generation sequencing techniques to identify on a genome-wide scale the DNA-binding profiles and direct transcriptional target genes of Ascl1 and Olig2 in glial progenitors in comparison to tumor cells of the glioblastoma mouse model. The culmination of this study will lead to new insights on the genetic regulatory networks of glial heterogeneity and glioblastoma development in the central nervous system.
|
0.946 |