We are testing a new system for linking grants to scientists.
The funding information displayed below comes from the
NIH Research Portfolio Online Reporting Tools and the
NSF Award Database.
The grant data on this page is limited to grants awarded in the United States and is thus partial. It can nonetheless be used to understand how funding patterns influence mentorship networks and vice-versa, which has deep implications on how research is done.
You can help! If you notice any innacuracies, please
sign in and mark grants as correct or incorrect matches.
Sign in to see low-probability grants and correct any errors in linkage between grants and researchers.
High-probability grants
According to our matching algorithm, Christopher Glenn Wilson is the likely recipient of the following grants.
Years |
Recipients |
Code |
Title / Keywords |
Matching score |
2006 — 2009 |
Wilson, Christopher G |
R01Activity Code Description: To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies. |
Astrocytes in Neonatal Respiration @ Case Western Reserve University
[unreadable] DESCRIPTION (provided by applicant): Irregularities in breathing pattern during early post-natal life are common but not well understood. Unstable respiratory patterns-for example, apnea of prematurity-are the result of perturbations in the respiratory rhythm generating neural network within the mammalian brainstem. Our current understanding of age-dependent changes suggests that single cell properties and a balance between excitation and inhibition within the local neural network are modulated by endogenous neural modulators like adenosine. Methylxanthines (e.g. caffeine) block adenosine receptors and are typically administered to reduce apneas and breathing irregularity, we seek to understand the mechanism by which adenosine contributes to normal, regular, respiratory pattern generation. Our preliminary data suggest that an interplay between inspiratory neurons and astrocytes within the respiratory rhythm generating/pattern forming network (preBotzinger complex, or pBc) is responsible for stabilizing breathing pattern. We hypothesize that maturational changes in inspiratory neurons and maturation of astrocytes within the pBc during development, promote the emergence of a stable, regular breathing pattern. Adenosine modulates the excitability of both neurons and astrocytes by activating A2 (both A and B) adenosine receptor subtypes. We will use immunohistochemistry to quantify the distribution of neurons and astrocytes during development and then selectively impair astrocytes and quantify changes in inspiratory drive in vitro using electrophysiological methods. Additionally, we will apply A2 adenosine receptor agonists and antagonists to individual neurons and astrocytes during whole-cell patch-clamp recording to evaluate the role that adenosine A2 receptors have in membrane excitation and inhibition. This proposal will determine the mechanisms by which astrocytes and adenosine interact during early maturation, a time of increased susceptibility to life threatening problems of central respiratory rhythm generation. [unreadable] [unreadable] [unreadable]
|
0.936 |
2010 — 2011 |
Wilson, Christopher G |
R03Activity Code Description: To provide research support specifically limited in time and amount for studies in categorical program areas. Small grants provide flexibility for initiating studies which are generally for preliminary short-term projects and are non-renewable. |
Intermittent Hypoxia and Retinopathy of Prematurity @ Case Western Reserve University
DESCRIPTION (provided by applicant): Intermittent desaturation episodes are a significant clinical problem in preterm infants as a consequence of immature respiratory control. These alterations in oxygenation are unpredictable and are probably due to sudden, dynamic changes in ventilatory drive. Hypoxia/hyperoxia events are difficult to control using threshold alarms in the neonatal intensive care unit and, although continuous pulse oximetry monitoring has been in use for many years, this technology has yet to be used to characterize the true incidence of intermittent hypoxic episodes in preterm infants and to further assess the relationship of these events to neonatal morbidity. As part of a multicenter study of oxygen supplementation, Rainbow Babies and Children's Hospital has generated two patient data sets that include long-term, high resolution monitoring of oxygen saturation via pulse oximetry. The two infant cohorts, comprising a total of 174 infants, include: 1) infants enrolled in the multicenter SUPPORT trial and 2) infants meeting enrollment criteria but not enrolled in the SUPPORT trial who received normal clinical care. Preliminary data analysis in the second cohort have revealed a significantly higher incidence of desaturation (<80% SaO2) events in infants developing ROP requiring laser therapy. However, there is large inter- and intra-patient variability in the pattern of desaturation episodes over time;additionally, data in animal models has suggested an association between patterns of desaturation events and ROP severity. We hypothesize that repetitive desaturation/resaturation events will result in clustering of hypoxia and hyperoxia events and present a significant risk factor for ROP in extremely low birth weight infants younger than 28 weeks gestational age. To test this hypothesis we will use our existing database of long-term measurements of oxygen saturation obtained via pulse-oximetry for all 174 infants gathered over 8 weeks of NICU care. In Specific Aim 1, we will use temporal and spectral analysis methods to quantify the linear properties of this patient dataset;additionally we will quantify clustered intermittent hypoxia and hyperoxia events using both linear and non-linear statistical methods to quantify the signal components present in the data. In Specific Aim 2, we will use a linear mixed model and discriminant analysis to distinguish patterns of desaturation, resaturation, and hypersaturation in infants who do and do not require laser treatment for ROP. PUBLIC HEALTH RELEVANCE: Intermittent desaturation episodes are a significant clinical problem in preterm infants as a consequence of immature respiratory control. Higher incidence of intermittent hypoxic (desaturation) episodes is associated with retinopathy of prematurity (ROP), a condition which can lead to life-long visual impairment and blindness. However, animal models have suggested that variable patterns in the intervals between desaturation episodes are an additional risk factor for ROP. In this application we propose analysis methods to quantify clustered intermittent hypoxia and hyperoxia events in order to minimize risk for ROP in very low birth weight infants. Identification and elimination of these patterns of intermittent hypoxia may lead to reduced incidence of ROP.
|
0.936 |