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High-probability grants
According to our matching algorithm, Da-Ting Lin is the likely recipient of the following grants.
| Years |
Recipients |
Code |
Title / Keywords |
Matching
score |
| 2015 — 2016 |
Lin, Da-Ting |
ZICActivity Code Description:
Undocumented code - click on the grant title for more information. |
Development of Cutting-Edge Optical Imaging Systems For in Vivo Imaging in Live Animals @ National Institute On Drug Abuse
We have developed a custom two-photon imaging system in NIDA IRP BRC building. The new custom two-photon system, combined with GRIN lens imaging, allows deep brain imaging in live animals with cellular and subcellualr resolution, and is currently been shared by entire NIDA IRP community. We have also developed a miniScope system that allows imaging of neuronal circuit function with single neuron resolution in freely moving animals in deep brain regions. The miniScope has been applied to freely moving mice imaging in NIDA IRP, and are currently been applied to in vivo imaging in freely moving rats. We are also developing a image relay fiber based optical imaging system that could be combined with fMRI imaging, this new imaging technique will be apply to NIDA IRP research with the euro imaging branch in the near future, allowing detailed examination of fMRI BOLD signal and neuronal circuit activity in the same animal simultaneously.
|
0.958 |
| 2015 — 2018 |
Lin, Da-Ting |
ZIAActivity Code Description:
Undocumented code - click on the grant title for more information. |
In Vivo Imaging of Dorsal Striatum Function in Freely Behaving Mice @ National Institute On Drug Abuse
Using our custom developed miniScope system, we imaged neuronal activity in dorsal striatum in freely moving mice, we also recorded mice locomotor activity, and compared neuronal activity to mice locomotor activity. We found that direct and indirect pathway neurons in the dorsal striatum displayed similar population activity. We further construct neuron cluster models based on our calcium recordings, and uncovered functional heterogeneity amount direct and indirect pathway neurons in dorsal striatum. Going forward, we will use this imaging technique to study how cocaine, THC and other substances of abuse alters dorsal striatum neuronal circuit function, and their contribution in the development of long-term drug addiction and relapse
|
0.958 |