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High-probability grants
According to our matching algorithm, Earl Godfrey is the likely recipient of the following grants.
Years |
Recipients |
Code |
Title / Keywords |
Matching score |
1984 — 1989 |
Godfrey, Earl |
N/AActivity Code Description: No activity code was retrieved: click on the grant title for more information |
An Extracellular Matrix-Associated Factor That Aggregates Acetylcholine Receptors @ Medical College of Wisconsin |
0.931 |
1998 |
Godfrey, Earl |
P41Activity Code Description: Undocumented code - click on the grant title for more information. |
Overexpression of Agrin At Developing Neuromuscular Synapses @ University of Wisconsin Madison
The immediate goal of these experiments is to understand the role of agrin in the formation of the embryonic neuromuscular junction. Agrin is a protein made and externalized by the motor nerve terminal that causes the postsynaptic apparatus to form on muscle cells. Currently we are using Xenopus (frog) embryos as an assay system for agrin and other molecules thought to be involved in formation of this synapse. We are assaying the function of agrin isoforms and domains by overexpressing the proteins in the embryo. RNA encoding agrin proteins is injected into early blastomeres of the embryo; it is mixed with RNA encoding the green fluorescent protein (GFP) as a marker. After about 38 hours of development, tadpoles are screened for expression of GFP in the ryot6mal muscles or spinal cord of the trunk. Embryos are fixed and the acetylcholine receptors (AChRs) are stained with rhodamine-bungarotoxin. The AChR aggregates in GFP-positive regions of the embryos are imaged by confocal microscopy. Several Z-series are taken from each group of embryos in an experiment. The volume of AChR aggregates in the myotomes; imaged is quantitated using Metamorph image analysis software. Results to date indicate that overexpression of both neuronal and muscle isoforms of agrin result in a significant increase in AChR aggregate volume. These results suggest that both isoforms of agrin may be important in the formation of the neuromuscular synapse in the developing embryo.
|
0.909 |
2001 |
Godfrey, Earl W |
S10Activity Code Description: To make available to institutions with a high concentration of NIH extramural research awards, research instruments which will be used on a shared basis. |
Confocal Microscopy System @ Eastern Virginia Medical School
Funds are requested to purchase a new Leica TCS SP2 confocal microscope for the imaging core facility in the Division of Anatomy at Eastern Virginia Medical School. The facility will serve the entire campus. Major users are nine NIH-funded investigators from four departments at EVMS. Between them, the major users have 15 NIH grants. The P.I., Dr. Godfrey, has used confocal microscopy as a major tool in his NIH funded research for five years. The facility is directed by Mr. Michael Adam, who has 13 years experience directing microscopy facilities. The major reason we are requesting this instrument is to facilitate the research of the major user group and that of new investigators who will be hired over the next several years. The existing microscopy facilities at EVMS are inadequate to support the experiments outlined in this proposal. In order to maintain and expand the NIH funding of the major user group and others, it is necessary to modernize the imaging core facility with the addition of a state-of-the-art confocal microscope and image analysis system. The requested instrument would give us the capability to image 3 fluors simultaneously and in addition has a transmitted light detector. The spectral tuning feature allows users to customize the wavelengths of emitted light that are detected by each channel, permitting maximum flexibility in the combinations of labels that can be utilized. This instrument would serve as the centerpiece of a modern imaging facility to facilitate NIH funded research at EVMS.
|
0.958 |