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Area:
Biogenesis, transport, degradation, mitochondria, mathematical modeling, biophysical analysis, genetic screens, targeted gene disruption, behavioral studies, drosophila, chicken.
Website:
http://millerlab.zoology.msu.edu/index.html
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High-probability grants
According to our matching algorithm, Kyle E. Miller is the likely recipient of the following grants.
Years |
Recipients |
Code |
Title / Keywords |
Matching score |
1998 — 2000 |
Miller, Kyle E [⬀] |
F32Activity Code Description: To provide postdoctoral research training to individuals to broaden their scientific background and extend their potential for research in specified health-related areas. |
Purification of Novel Kinesin Receptors
The kinesin receptor kinectin is the only reported protein that binds vesicles to kinesin, and it has been shown to be localized to the cell bodies of neurons (Toyoshima et al., 1992; Kumar et al., 1995; Toyoshima and Sheetz, 1996). Its absence from the axon in contrast to the ubiquitous distribution of kinesin strongly suggests the existence of other kinectin-like proteins in neurons. In addition, in the experiments that originally identified kinectin, 20 other uncharacterized protein were found that interacted with either kinesin and vesicles. While kinectin was the most abundant of these proteins, the unexplored possibility remains that one or more of the other proteins is also a vesicle associated kinesin receptor (Toyoshima et al., 1992; Toyoshima and Sheetz, 1996). The purpose of these experiments is to identify novel kinesin receptors that may play important roles in the generation of sub-cellular organelles and in fast axonal transport. To do this, we will immunodeplete chick embryo brain of kinectin bound vesicles, and then purify kinesin binding proteins from the remaining vesicle population. Next we will microsequence and then generate monoclonal antibodies to the purified proteins, and then use the antibodies to verify the purified proteins function, to clone the purified proteins, and to determine their localization.
|
0.97 |
2010 — 2015 |
Miller, Kyle [⬀] |
N/AActivity Code Description: No activity code was retrieved: click on the grant title for more information |
The Role of Forces in Axonal Elongation @ Michigan State University
Axons are long cellular cables that conduct information through the nervous system. Despite a century of investigation, how axons elongate is poorly understood. This question is important because axonal elongation wires the brain during development and is ultimately responsible for how individuals think and perceive the world. The PI's approach to studying this problem is to monitor the process of axonal elongation in vivo using advanced microscopy in living intact Drosophila (fruitfly) embryos, and in vitro on individual neurons grown on glass coverslips. These classic cell biological approaches will be combined with biophysical analysis and powerful genetic tools developed in Drosophila to answer the following questions: 1) What are the cellular mechanics of elongation in vitro and in vivo? (2) How do forces control axonal assembly? (3) How do guidance cues cause axons to turn? Answering these questions will illuminate the understanding of the genetic and cellular mechanisms of axonal elongation. This project will support the training of graduate and undergraduate students, and has an outreach component that exposes K-12 students, undergraduates, graduate students, and secondary physical science teachers to cell biology, genetics, microscopy, and contemporary questions in neuroscience.
|
0.915 |