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High-probability grants
According to our matching algorithm, Andrea L. Behrman is the likely recipient of the following grants.
Years |
Recipients |
Code |
Title / Keywords |
Matching score |
2000 — 2004 |
Behrman, Andrea L |
K01Activity Code Description: For support of a scientist, committed to research, in need of both advanced research training and additional experience. |
Activity-Dependent Plasticity After Spinal Cord Injury
The applicant's long-term career goal is to develop scientifically-based therapies to advance the physical rehabilitation and recovery of function in persons after spinal cord injury (SCI). The applicant's current goal is to build on her clinical expertise in SCI physical rehabilitation, apply her doctoral training in motor control, and merge advanced knowledge and research skills to develop as an independent and competitive investigator bridging basic and clinical research in SCI rehabilitation. A five-year research and training plan developed with the primary mentor, F. Thompson, PhD of the University of Florida Brain Institute (UFBI) will meet this goal. This plan capitalizes on current collaborations, mentorship, and research expertise of SCI researchers at the UFBI. The aims of this award are to: 1) enrich the candidate's research and experimental design skills; 2) advance current knowledge of spinal cord neurophysiology and activity-dependent plasticity; 3) develop the techniques to assess spinal cord neurophysiological function; and 4) enhance research support skills including scientific writing and grantsmanship. New approaches to facilitate locomotor recovery in individuals after SCI have recently been explored that optimize activity- dependent plasticity using sensory information related to locomotion to improve walking. Locomotor training velocity may be a critical, activity-dependent parameter affording appropriate phasic input to the neural system. In the proposed research, the relationship between neurophysiological mechanisms that sub-serve locomotion and walking velocity overground and on a treadmill will be compared in control subjects and subjects with incomplete SCI. For subjects with incomplete SCI, the effects of training velocity and a long-term locomotor training program on spinal cord reflex modulation function and overground walking velocity will then be assessed. The goal of this research is to assess if long-term locomotor training at a specific velocity in individuals with incomplete SCI will better facilitate neuroplasticity measured by improvements of spinal cord reflex function and increases in walking velocity.
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1 |
2008 |
Behrman, Andrea L |
R01Activity Code Description: To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies. |
Intermuscular Coordination of Hemiparetic Walking
DESCRIPTION (provided by applicant): A central disability associated with post-stroke hemiparesis is that muscle excitation is impaired, and thus muscles fail to produce properly graded and timed force. With impaired muscle coordination, walking subtasks required to achieve normal speed, such as trunk forward progression (acceleration), swing initiation (kinetic energy of the leg at the end of stance) and muscle power generation, may not be satisfactorily performed. The relationship between impaired muscle force production and walking speed in persons with hemiparesis is unknown, yet this is extremely important for the design of effective gait rehabilitation strategies in hemiparetic populations. In the proposed study, experimental data from individuals with post-stroke hemiparesis across a range of functional walking levels and speed-matched healthy elderly individuals will be combined with a theoretical modeling framework based on dynamic simulations to quantify muscle force contributions to walking. The PIs propose to use this scientific model-based framework to understand and quantify how abnormal muscle force production reduces walking speed in post-stroke gait disorders. Specific aims are to (1) determine how deficits in trunk forward progression, swing initiation and muscle power generation are caused by abnormalities in muscle force production during pre-swing in the paretic leg, and how abnormalities during concomitant early stance in the non-paretic leg compensate; and (2) determine how muscle coordination must be improved for subjects with hemiparesis to increase their functional walking status. The long-term objectives of the proposed work are to show that measures of abnormal muscle coordination in post-stroke walking will predict the outcome of therapy, assist in defining the specific muscle coordination changes associated with various therapeutic interventions, and correlate with structural and functional studies of the nervous system such that the underlying mechanisms can be better understood.
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1 |