Area:
pain, mind-body medicine
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High-probability grants
According to our matching algorithm, Yoshio Nakamura is the likely recipient of the following grants.
Years |
Recipients |
Code |
Title / Keywords |
Matching score |
2003 — 2006 |
Nakamura, Yoshio |
R01Activity Code Description: To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies. |
A Dynamic Contructivist Model of Placebo Analgesia
[unreadable] DESCRIPTION (provided by applicant): This application responds to RFA: AT-02-002, 'Elucidation of the Underlying Mechanisms of Placebo Effect,' co-sponsored by 12 NIH institutes. Its key themes are non-pharmacological analgesia, consciousness, emotion, psychophysiology, somatic perception, individual differences, and time series analysis. The overall objectives of the proposed 4-year program of research are to validate a new theoretical approach to non-pharmacological analgesia through theory-driven, dynamic modeling grounded in structural equation reasoning. The work assumes a constructivist theoretical framework, which holds that the brain continuously constructs and revises a model of reality that includes both the external world and the body. When a noxious event occurs, the brain constructs pain as a part of ongoing consciousness from unconsciously activated schemata. Placebo analgesia reflects an altered construction of pain. A time series model provides a basis for evaluating predictions derived from constructivism in studies designed to create placebo analgesia. Two studies will investigate normal volunteers who undergo painful but harmless laboratory stimulation during a placebo manipulation that purports to relieve pain. The primary indicator for placebo analgesia is reduction in multivariate psychophysiological arousal to painful events. Study 1 (80 subjects) tests the hypotheses that greater expectancy for pain relief produces greater reduction in psychophysiological arousal to painful stimuli, and placebo analgesia is stronger when active rather than passive expectancy for pain relief can alter the subsequent construction of pain. Study 2 (125 subjects) focuses on placebo analgesia as a process that depends on somatic perception and expectancy, using a time series model. It tests the hypothesis that the task demand of producing a pain rating will decrease placebo analgesia by interfering feedback mechanisms that would normally revise expectancy. An additional purpose is to identify and explain individual differences in ability to benefit from a placebo. The proposed work will advance understanding of placebo analgesia by introducing and validating constructivism as a theoretical framework for placebo mechanisms, by examining the placebo effect as a dynamic process, and by contributing an unprecedented, testable explanatory time series model. [unreadable] [unreadable]
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1 |
2004 — 2006 |
Nakamura, Yoshio |
R21Activity Code Description: To encourage the development of new research activities in categorical program areas. (Support generally is restricted in level of support and in time.) |
Utah Center For Exploring Mind-Body Interactions (Ucemb*
[unreadable] DESCRIPTION (provided by applicant): This R21 application proposes to establish an exploratory mind-body research program (Utah Center for Exploring Mind-Body Interactions, UCEMBI) within the Pain Research Center at the University of Utah. This program will promote and facilitate transdisciplinary and translational approaches to investigating mind-body interactions and their relationship to health. The primary focus of the proposed research is somatic awareness and its control through mind-body interactions, and the secondary focus is systematic investigations of functional somatic syndromes. Although our primary strength is pain research, the scope of interest extends to awareness of all forms of somatic symptom, including fatigue, nausea, vertigo, dyskinesia, and dystonia. The proposed exploratory center has five central objectives. The first is to develop an infrastructure to investigate mind-body interactions by creating three integrated core support units that serve both currently existing and new pilot research projects at the PRC. The three core units are: Assessment, Methodology and Statistics; Technology-Based Assessment using functional brain imaging and multivariate psychophysiology; and Administrative Support. UCEMBI will support two peer-reviewed pilot studies each year for three years using core resources. Second, UCEMBI will enhance the existing research environment at the University of Utah by facilitating interdisciplinary collaborations between the proposed center and other relevant research units on the campus, and by advancing understanding of the role of somatic awareness in functional somatic syndromes within an integral framework of constructivism and multilevel analytical approach. UCEMBI will attempt to integrate research approaches at different levels of inquiry ranging from neuroscience to sociology. Third, UCEMBI will establish a vibrant intersection of pain research, consciousness studies, and investigations of mind-body interactions that will open new visions for mind-body research. Fourth, UCEMBI will introduce new theoretical frameworks and methodological approaches for research on somatic awareness and its relationship to mind-body interactions in three specific areas: a) the use of magnetoencephalography to document alterations in somatic awareness in mind-body interactions, b) combined use of both "dry" and "wet" psychophysiological measures to characterize alterations in somatic awareness in mind-body interactions, and c) integrative synthesis of qualitative and quantitative assessments of alterations in somatic awareness in mind-body interactions. Finally, UCEMBI will strive to raise professional and public awareness of a) the potential value of mind-body medicine in general and b) the importance of somatic awareness in enhancing physical and mental health. [unreadable] [unreadable]
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1 |