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High-probability grants
According to our matching algorithm, Joseph Duman is the likely recipient of the following grants.
| Years |
Recipients |
Code |
Title / Keywords |
Matching
score |
| 2005 — 2007 |
Duman, Joseph G |
F32Activity Code Description:
To provide postdoctoral research training to individuals to broaden their scientific background and extend their potential for research in specified health-related areas. |
Calcium Dynamics in Secretory Granule-Containing Cells @ University of Washington
DESCRIPTION (provided by applicant): Ca2+ is a second messenger regulating many vital processes; therefore, cellular mechanisms for inciting, terminating, and shaping Ca2+ signals attract intense research. Ca2+ fluxes between the cytosol and both the extracellular space and the endoplasmic reticulum (ER) are the best-understood components of Ca2+ dynamics. However, other organelles, such as secretory granules (SG), may also contribute. It has long been known that SG maintain Ca2+ levels well above those of the cytosol. Recent work demonstrating the presence of functional release channels and emphasizing the highly localized action of Ca2+ signals further argues that SG represent important components of the cellular Ca2+ signaling ma- chinery. A confounding factor has been that SG transport protons as well as Ca2+; this complicates Ca2+ measurements by affecting Ca2+ reporters and altering SG Ca2+ buffering. The research in this proposal will quantitatively dissect global cellular Ca2+ transport in SG-containing cells, characterize the Ca2+ buffering capacity of SG, and measure the response of SG Ca2+ to cell stimuli while measuring pH effects on reporters and SG buffers. Ca2+ and pH photometry using both chemical probes and genetically-encoded reporters will be used in both intact neuroendocrine cells and isolated SG to achieve these goals. The results will lead to better understanding of Ca2+ dynamics in neuroendocrine cells, as well as in other clinically relevant cells in which SG Ca2+ is potentially important, including pancreatic beta-cells and mast cells.
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0.958 |