Tsafrir S. Mor - US grants

Affiliations:

Arizona State University, Tempe, AZ, United States

Area:

Molecular Biology, Neuroscience Biology

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High-probability grants

According to our matching algorithm, Tsafrir S. Mor is the likely recipient of the following grants.

Years	Recipients	Code	Title / Keywords	Matching score
2004 — 2005	Mor, Tsafrir Shlomo	R21Activity Code Description: To encourage the development of new research activities in categorical program areas. (Support generally is restricted in level of support and in time.)	Aids Prevention: Mucosally-Targeted Plant Based Vaccines @ Arizona State University-Tempe Campus DESCRIPTION (provided by applicant): Despite the success of extensive AIDS prevention programs and powerful anti-retroviral drugs in limiting the spread of HIV-1 in high-income countries, it is generally agreed that for the developing world, these efforts will have to be combined with effective vaccines, but the design and testing of such vaccines have proven to be complex. It has been suggested that mucosal antibodies have an important role in preventing HIV-1 from crossing the epithelial barrier and ultimately in providing protection from infection. We propose to utilize fusion protein engineering and transgenic plants as a vaccine production platform in order to develop a mucosally-targeted subunit vaccine that provoke local and systemic immune responses against a broad range of HIV-1 subtypes to prevent the atraumatic sexual transmission of the virus. The main objective of this proposal centers on the development of such a candidate vaccine based on a fusion protein consisting of the mucosal-targeting B subunit of cholera toxin (CTB) and the conserved cerebroside (GalCer) binding domain (including the ELDKWA neutralizing epitope, a.a. 649-681, the "P1" peptide) of the HIV-1 gp41 envelope protein, which mediates the transcytosis of HIV-1 across the mucosal epithelia. The CTB-P1 chimera will be expressed in bacteria and in plant cells. We will then test its potential to elicit mucosal and systemic immune responses against HIV-1 in mice and assay the antibodies' capacity to neutralize transcytosis and infection. We believe that this new technology of plant-derived ("edible") vaccines emerging from the combination of immunology and plant genetic engineering has the potential to significantly impact the field of HIV/AIDS vaccine development in providing efficacious, cost-effective and safe (needle-free) vaccines. While it is probable that a single form of vaccination would not be effective in isolation, the plant-based vaccine may be combined with other types of vaccines in a prime/boost strategy. Show summary Hide summary	1
2006 — 2010	Mor, Tsafrir Shlomo	U54Activity Code Description: To support any part of the full range of research and development from very basic to clinical; may involve ancillary supportive activities such as protracted patient care necessary to the primary research or R&D effort. The spectrum of activities comprises a multidisciplinary attack on a specific disease entity or biomedical problem area. These differ from program project in that they are usually developed in response to an announcement of the programmatic needs of an Institute or Division and subsequently receive continuous attention from its staff. Centers may also serve as regional or national resources for special research purposes, with funding component staff helping to identify appropriate priority needs.	Rapid and Large Scale Plant-Based Production of Catalytic Nerve Agent Bioscavenge @ U.S. Army Medical Research Inst Chem Def	0.903