Affiliations: | | | Binghamton, Binghamton, NY, United States |
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High-probability grants
According to our matching algorithm, David F. Werner is the likely recipient of the following grants.
Years |
Recipients |
Code |
Title / Keywords |
Matching score |
2011 — 2013 |
Werner, David F |
P50Activity Code Description: To support any part of the full range of research and development from very basic to clinical; may involve ancillary supportive activities such as protracted patient care necessary to the primary research or R&D effort. The spectrum of activities comprises a multidisciplinary attack on a specific disease entity or biomedical problem area. These grants differ from program project grants in that they are usually developed in response to an announcement of the programmatic needs of an Institute or Division and subsequently receive continuous attention from its staff. Centers may also serve as regional or national resources for special research purposes. |
Pilot 5 - Developmental Exposure Alcohol Research Center @ State University of Ny,Binghamton
Ethanol neurotoxicity affects neurotransmitter release. Experiments will be carried to test the hypothesis that ethanol exposure results in structural and biochemical changes in presynaptic terminals. First, a transgenic mouse that expresses yellow fluorescent protein (YFP) in a subset of cerebellar mossy fiber terminals will be used to determine whether ethanol treatment affects the size of the mossy fiber terminals. Second, the effect of ethanol on presynaptic protein SNAP-25 will be determined. These experiments will provide novel insights on how ethanol affects cerebellar circuitry at presynaptic terminals.
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1 |
2019 — 2021 |
Werner, David F |
P50Activity Code Description: To support any part of the full range of research and development from very basic to clinical; may involve ancillary supportive activities such as protracted patient care necessary to the primary research or R&D effort. The spectrum of activities comprises a multidisciplinary attack on a specific disease entity or biomedical problem area. These grants differ from program project grants in that they are usually developed in response to an announcement of the programmatic needs of an Institute or Division and subsequently receive continuous attention from its staff. Centers may also serve as regional or national resources for special research purposes. |
Behavioral Resource, Analysis and Integrative Neuroscience (Brain) Core @ State University of Ny,Binghamton
PROJECT SUMMARY/ABSTRACT BRAIN CORE The Behavioral Resource, Analysis & Integrative Neuroscience (BRAIN) Core provides key technical and research design support for all main and pilot projects associated with the DEARC. A primary goal of the DEARC is to characterize and analyze the brain and behavioral adaptations that emerge as a result of ethanol (EtOH) exposure at various developmental stages. The BRAIN Core plays several critical roles within the Center: it provides expertise and training in breeding, EtOH exposure paradigms, behavioral assessments and the evaluation of sex differences (Aim 1). Resources and expertise for the implementation of molecular and genetic techniques for assessments of developmental EtOH effects are also provided by the BRAIN Core (Aim 2). For the evaluation of neuroanatomical changes associated with developmental EtOH exposure, the BRAIN Core will maintain microscope systems and provide training for immunohistochemical approaches coupled with rigorous quantitative analysis (Aim 3). The BRAIN Core provides access to consultation for advanced statistical techniques for complex and unique data sets (Aim 4). It is the mission of the BRAIN Core to provide critical methodological resources to all DEARC affiliated components by (1) supplementing scientific rigor; (2) training research personnel and assisting PI?s in the authentication of key biological and chemical resources used in experiments; (3) augmenting the strong collaborative foundation for data and resource sharing; and (4) creating an environment that cultivates insight and approaches to deal with nascent findings and potential synergisms across projects.
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1 |
2020 — 2021 |
Varlinskaya, Elena I Werner, David F |
U01Activity Code Description: To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies. |
2/8 Nadia U01 Adolescent Alcohol Exposure: Neural Contributors to Sex- and Exposure Timing-Specific Anxiety @ State University of Ny,Binghamton
Project Summary Our current work in the NIAAA consortium on the Neurobiology of Adolescent Drinking in Adulthood (NADIA) has revealed that long-lasting behavioral consequences of adolescent intermittent ethanol exposure (AIE) are sex- and exposure timing-dependent. When tested in adulthood, only male rats exposed to ethanol during early-mid adolescence (early AIE) demonstrate social alterations that include social anxiety and enhanced sensitivity to ethanol-induced social facilitation, with exposure to ethanol later in adolescence (late AIE) having no such consequences. Our most important translational finding is that a selective oxytocin receptor (OXTR) agonist reverses the male-specific social anxiety. At the cellular and molecular levels, sex-specific consequences of early AIE are evident as alterations in dendritic spine morphology and decreases in OXTR mRNA and protein expression in the hypothalamus. Our current proposal will address critical gaps arising from this work. Aim 1 will identify socially relevant regions differentially activated in adult males and females by social stimuli following early AIE and will test whether recruitment of neuronal ensembles in identified brain regions is required for male-specific social affective alterations. Aim 2 will further assess AIE-induced alterations of the OXT system contributing to male-specific social anxiety and will investigate neural mechanisms underlying the reversal effects of OXTR pharmacological activation. Aim 3 is designed to test whether AIE selectively disrupts epigenetic regulation of the OXT neuromodulatory peptide system in brain regions critical for normal social functioning.
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1 |