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High-probability grants
According to our matching algorithm, Stephen P. DeWeerth is the likely recipient of the following grants.
Years |
Recipients |
Code |
Title / Keywords |
Matching score |
2002 — 2006 |
Deweerth, Stephen P |
R01Activity Code Description: To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies. |
A 3-D Microfluidic/Electronic Neural-Interfacing System @ Georgia Institute of Technology
[unreadable] DESCRIPTION (provided by applicant): Investigators from multiple departments at the Georgia Institute of Technology / Emory University School of Medicine, from the University of Illinois at Urbana Champaign, and from the Southern Illinois University School of Medicine propose a multidisciplinary project to develop a microfabricated neuronal interfacing system (uNIS) for advanced interfacing to three-dimensional neural tissue in vitro, and to apply this technology to the study of plasticity and injury in neuronal networks. The specific aims of the project are formulated around the development and integration of a set of technological advances that facilitate the study of three-dimensional cell cultures and slices: (1) vertical towers with connecting crossbridges that provide infrastructure for the formation of structured networks as well as for the electrical connectivity; (2) the inclusion of microfluidic channels into these towers to selectively inject nutrients and trophic factors and to apply chemical stimulation to localized regions of the tissue; and (3) the design of integrated circuits that amplify, multiplex, and process the large number (>1000) of signals generated in the uNIS and that facilitate simultaneous recording and stimulation. This technology will be applied directly to the study of three-dimensional, in vitro neural tissue with a particular focus on hypotheses addressing the development of functional networks of neurons, the role of plasticity in these networks, and the study of injury and its effects on network behavior. During the first year of the grant, prototypes of the microtowers, microfluidic structures, and electronics will be developed and integrated with neural tissue. The remainder of the five-year grant will focus on the refinement and testing of the technology and on a set of biological experiments that validate the approach and test the proposed hypotheses. The successful completion of this project will result in the creation of a technological framework for studying a wide variety of cells (neural and non-neural) as well as experimental data that would be inaccessible without this three-dimensional technology.
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1 |
2007 — 2009 |
Deweerth, Stephen P |
R01Activity Code Description: To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies. |
Closed-Loop Control of Spinal Motor Circuits Using a Multi-Electrode Interface @ Georgia Institute of Technology
DESCRIPTION (provided by applicant): Approximately 250,000 Americans currently suffer from spinal cord injury or disease, which can cause paralysis and other deteriorations in quality of life. Our project's objective is to build a prosthetic device that has potential to help Spinal Cord Injury patients regain their ability to control their body's movements and, in particular, their ability to walk. Multiple labs have shown that it is possible to evoke walking patterns in the spinal cord directly, via electrodes that stimulate the surface of the spinal cord. Additionally, stimulating the cord electrically at certain cites have been shown to increase or decrease the speed of walking patterns. These studies have potential to be incorporated into a multiple-electrode prosthetic that can evoke and control walking output directly from the spinal cord, bypassing injury sites that block commands from the brain. Our proposed work uses a biocompatible, conformable array of electrodes that can activate walking output when stimulating electrically the surface of the mammalian spinal cord (we use the neonatal rat spinal cord as our model). Our proposed experiments are designed to identify optimal multi-site locations on the spinal cord surface that, when electrically stimulated at low amplitudes and frequencies, initiate and control spinal cord locomotor (i.e. walking) output. Identification of such sites and stimulation patterns is necessary to our overall objective of creating a multi-electrode, implantable prosthetic for restoration of walking capability in Spinal Cord Injury (SCI) patients.
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1 |