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High-probability grants
According to our matching algorithm, Hawley E. Montgomery-Downs is the likely recipient of the following grants.
Years |
Recipients |
Code |
Title / Keywords |
Matching score |
2003 — 2004 |
Montgomery-Downs, Hawley E |
F32Activity Code Description: To provide postdoctoral research training to individuals to broaden their scientific background and extend their potential for research in specified health-related areas. |
Snoring, Early Behavior, and Oxidant Stress @ University of Louisville
DESCRIPTION (provided by applicant): Daytime neurocognitive performance is impaired in adolescents and school-age children with sleep-disordered breathing (SDB). Furthermore, animal models of SDB clearly demonstrate that episodic hypoxia during sleep leads to both short-term and long-term decrements in learning and memory, and that these are mediated, at least in part, by oxidant stress. However, the prevalence and neurobehavioral consequences of SDB during the first 2 years of life are unknown. To address this issue, we will examine the hypothesis that infants who develop SDB within their first 7 months will manifest reduced cognitive development by the end of their first year. Furthermore, infants with SDB will show increased oxidant markers in their urine. The following specific aims will therefore be examined: (1) a population survey for the potential presence of SDB will be conducted among 6 month-old infants; (2) Home-based polysomnography will be performed at 7 and 13 months in infants at high risk for SDB and matched controls; and an index of mental development will be administered; (3) The levels of 15-F2t-lsoprostane metabolites in urine will be determined, as correlates for oxidant stress. This longitudinal, prospective study will contribute to our understanding of the prevalence, and neurodevelopmental consequences of SDB in infancy. In addition, it may provide insights into a potential mechanism for this morbidity.
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0.939 |
2007 — 2008 |
Montgomery-Downs, Hawley E |
R21Activity Code Description: To encourage the development of new research activities in categorical program areas. (Support generally is restricted in level of support and in time.) |
Postpartum Sleep Deprivation and Fragmentation: Effects On Maternal Functioning @ West Virginia University
[unreadable] DESCRIPTION (provided by applicant): Postpartum Sleep Deprivation and Fragmentation: Effects on Maternal Functioning Federal regulations set work length limitations because insufficient sleep causes impairments that lead to accidents that endanger the public. Yet most new parents undergo long-term partial sleep deprivation, which is known to cause decrements in mood, cognition and motor functioning, and are simultaneously entrusted with the constant care of an infant. Sleep disruption is considered one of the key factors contributing to difficulties with maternal postpartum adjustment. However, sleep disruption is one of many changes accompanying the transition to parenthood and we do not know the independent effects of sleep disruption on this system. Nor do we know whether it is the overall sleep loss (deprivation) as opposed to frequent sleep interruption (fragmentation) that impairs functioning. Answering these questions will better direct clinical methods for improving the sleep of postpartum mothers. Based on the current body of literature, the proposed study's central hypothesis is that fragmentation of maternal sleep has a more negative impact on daytime functional ability than discrete sleep deprivation. In order to address the central hypothesis, and refine methods which may lead to substantial improvements in self-report field collection methods, the following Specific Aim will be addressed: Beginning at 4 weeks postpartum, primiparous mothers will undergo eight weeks of continuous sleep/wake pattern monitoring and assessments of daytime fatigue, mood, stress, performance, and affect will be collected. Handheld computers will be used for mothers' sleep log entries and to administer fatigue and performance assessments. The hypotheses are that 1) higher indices of sleep disruption (deprivation + fragmentation) will be associated with greater functional impairment. Viability of computerized sleep logs with this population will be determined. 2. Sleep fragmentation indices will account for greater variance in functional outcome measures than discrete deprivation. The study will look at sleep disruption in new mothers to determine whether the problems they have functioning during the daytime are a) because they don't get enough sleep, or b) because they don't get enough consolidated sleep. The study results will help researchers develop better strategies for improving the sleep of new mothers, and in turn improving their ability to function effectively. [unreadable] [unreadable] [unreadable]
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