Area:
hair cell physiology, molecular biology
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High-probability grants
According to our matching algorithm, Bernd Sokolowski is the likely recipient of the following grants.
Years |
Recipients |
Code |
Title / Keywords |
Matching score |
1987 |
Sokolowski, Bernd H |
F32Activity Code Description: To provide postdoctoral research training to individuals to broaden their scientific background and extend their potential for research in specified health-related areas. |
Auditory Nerve Responses to Efferent Stimulation @ Johns Hopkins University |
0.902 |
1993 — 1997 |
Sokolowski, Bernd H |
R29Activity Code Description: Undocumented code - click on the grant title for more information. |
Development of Excitation in the Inner Ear @ University of South Florida
DESCRIPTION: (Adapted from the Applicant's Abstract.) The avian inner ear is a useful model for studying the growth and development of the auditory and vestibular systems. One fundamental question concerns the regulation of growth and survival of the inner ear. In sensory cells and neurons one of the mechanisms regulating growth, survival, and synapses during development is the expression of excitation. This expression can be governed by variables extrinsic to the cell (e.g., innervation and growth factors) which in turn regulate mechanisms intrinsic to the cell (e.g., DNA transcription and protein modification). In light of this the present project will begin examining: 1) how interactions between hair cells and cochleovestibular ganglion (CVG) neurons regulate the development of excitation, and 2) how the development of excitation affects the growth, the survival, and the death of these cells. The whole-cell tight-seal recording technique will be used to measure the acquisition of voltage-gated currents in hair cells and neurons exposed to various conditions in vitro. Initially, the acquisition of ionic currents will be studied in the CVG, because the developmental data are incomplete. Subsequent experiments will focus on how neurotrophins (nerve growth factor, brain-derived neurotrophic factor, and neurotrophin-3) affect the survival and growth of the CVG in vitro. Using these data as a basis, the acquisition of voltage-gated currents will be measured in response to neurotrophins. Studies of hair cells will consider questions dealing with the extrinsic and intrinsic regulation of excitation.Experiments will examine how afferent innervation affects the development of ionic current in vitro and how the development of ionic currents may influence synaptogenesis. Immunohistochemistry will be used to follow the development of the synaptophysin molecule in conjunction with ionic current development. Studies of intrinsic mechanisms will examine whether functional expression of voltage-gated currents results from the transcription of a new gene or the post-translational modification of protein channels. The long term objectives of this project are to understand the cellular and molecular processes that regulate excitation in developing hair cells and CVG neurons, and to understand how this excitation affects growth, survival, and synaptogenesis in these cells. The results will provide insights into: causes of sensorineural deafness, regulation of CVG neurons by growth factors, and proteins involved with synaptogenesis.
|
0.958 |
2000 — 2015 |
Sokolowski, Bernd H |
R01Activity Code Description: To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies. |
Development of Excitation in Hair Cells @ University of South Florida
DESCRIPTION: (Adapted from the Investigator's Abstract) The avian inner ear is a dynamic model for studying the growth and development of excitation in auditory and vestibular hair cells. The underlying basis for excitation is membrane proteins that form ion channels. The acquisition of these channels is important for modulating auditory and vestibular excitation during development. Moreover, as in the visual system, excitation may "sculpt" the auditory systems. However, a fundamental unanswered question about these proteins is, what mechanisms regulate their expression? The acquisition of ion channels can be governed by extrinsic variables that include metabolites and proteins. Included among these molecules are retinoids and neurotrophins that bind to receptors and turn on intracellular pathways in differentiating hair cells. The neurotrophins can regulate the fate of presumptive cells of the inner ear by stimulating high (Trk) and low affinity (p75NTR) receptors. This stimulation may induce cell proliferation, death, differentiation, and potentially, the transcription of genes that encode potassium currents, such as the A-type current in hair cells. Retinoids contribute to this regulation by modulating the neurotrophin effect. The long-term objectives of this project are to understand how extrinsic factors regulate ion channel expression from an age when cells of the inner ear are morphologically undifferentiated to when they become hair cells. The experiments presented in this proposal will specifically examine: (1) candidate genes that encode the transient A-type potassium channel in hair cells, (2) expression and distribution of candidate genes in the embryo and adult sensory epithelium, (3) expression of the Trk and p75 neurotrophin receptors during development in vivo and in vitro, and (4) regulation of potassium current and candidate gene expression by neurotrophins and their intracellular messengers. The knowledge gathered from the proposed experiments will contribute to our understanding of the regulatory mechanisms that control ion channel genes in sensory cells of the inner ear. This knowledge is relevant to understanding how excitatory signals in sensory cells contribute to the normal and abnormal development of the auditory and vestibular systems.
|
0.958 |