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High-probability grants
According to our matching algorithm, Lina Ni is the likely recipient of the following grants.
Years |
Recipients |
Code |
Title / Keywords |
Matching score |
2020 |
Ni, Lina |
RF1Activity Code Description: To support a discrete, specific, circumscribed project to be performed by the named investigator(s) in an area representing specific interest and competencies based on the mission of the agency, using standard peer review criteria. This is the multi-year funded equivalent of the R01 but can be used also for multi-year funding of other research project grants such as R03, R21 as appropriate. |
Develop Functional Trans-Tango to Identify Higher-Order Neurons With Determined Functions @ Virginia Polytechnic Inst and St Univ
A neural circuit is composed of a population of neurons that are interconnected by synapses and carry out a specific function when activated. Thus, to identify a neural circuit, both the synaptic connections and the func- tional relevance of each neuron in the circuit must be examined. To date, few methods are available to study these two aspects of a neural circuit simultaneously. In the current proposal, this problem will be addressed using a new class of trans-synaptic techniques. Current trans-synaptic techniques enable the labelling of postsynaptic elements of first-order neurons without using driver lines. However, the ability to discriminate the function of each neuron in the circuit and the ability to track higher-order neurons remains lacking. A Drosophila thermosensory system that controls rapid warmth avoidance will be used as a model to demonstrate how a modified trans-synaptic technique can sparsely label both second- and higher-order neurons in a single neural circuit and determine their functional relevance to a specific behavioral response. The FLP/FRT recombination system will be used to sparsely label second- and higher-order neurons. Behavioral assays will be used to dis- criminate the functions of each labelled neuron. In Aim 1, the current trans-synaptic technique will be combined with the FLP/FRT recombination system and behavioral assays to sparsely label second-order neurons that are necessary and sufficient for a specific behavioral response. Aim 2 will use the same strategy as Aim 1 to sparsely label neurons that control discrete functions and express the trans-synaptic techniques in second-order neurons to track higher-order neurons. Therefore, in Aim 2, higher-order neurons that are necessary and sufficient for a specific behavioral response will be sparsely tracked. The expected outcome of this proposal is development of a tool that can (1) sparsely label synaptically interconnected second- and higher-order neurons without using driver lines, and (2) determine the function of labelled neurons. The tool will be able to be readily applied to many other Drosophila neural circuits, where the synaptic connections and the functional relevance of each neuron will be simultaneously identified. Moreover, it has the potential to provide an alternative for labelling mammalian circuits.
|
0.978 |
2021 |
Ni, Lina |
R01Activity Code Description: To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies. |
Demonstrate the Molecular Receptor and Functions of Dorsal Organ Warm Cells in Flies @ Virginia Polytechnic Inst and St Univ
Summary ? Lina Ni Animals depend on their temperature-sensing systems to avoid noxious thermal extremes and to seek optimal temperatures for survival. Temperature sensation is particularly relevant for small animals, such as insects, which rely on ambient temperatures to set their body temperatures. Many insect vectors of diseases, such as mosquitoes, respond to the temperature of their warm-blooded hosts and use it to guide the blood- feeding behaviors through which they transmit human diseases. Thus, it is important to identify the temperature- sensing molecules and neurons to help control disease vectors. Fruit flies are a suitable model system for these studies, because of their evolutionarily conserved temperature-sensing molecules with mosquito. In flies, many temperature-sensing systems possess a small number of temperature sensory neurons that master robust behaviors. Moreover, the powerful genetics developed in flies ensures the precise manipulation of temperature- sensing molecules and neurons. Preliminary studies from the PI?s lab discovered a set of previously unidentified warm-activated neurons in fly larvae, whose temperature-sensing molecules and functions are unknown. Preliminary data suggested that these neurons depended on a new class of warm-sensing molecules to detect warm temperatures. Besides a classic function of temperature-responsive neurons that determine temperature preference, these neurons may have an additional function to modulate their neighboring cool-activated neurons. Such modulation may result in change of physiological properties in neighboring neurons. The goal of this application is to identify the warm-sensing molecules in these warm-activated neurons, to demonstrate their functions in temperature preference, and to determine their modulatory effects on neighboring neurons. In addition to having preliminary data, we are particularly well-prepared to undertake the proposed research because of our extensive, and successful, track record of studying temperature-responsive molecules and sensory neurons in flies. Since the potential candidates of the warm-sensing molecules are conserved between flies and mosquitoes, this study might provide novel targets to control blood-feeding behaviors of mosquitoes and other disease vectors.
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0.976 |