Area:
Drugs of abuse: peripheral actions and cardiovascular effects
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High-probability grants
According to our matching algorithm, Eugene A. Kiyatkin is the likely recipient of the following grants.
Years |
Recipients |
Code |
Title / Keywords |
Matching score |
1997 — 1999 |
Kiyatkin, Eugene A |
K01Activity Code Description: For support of a scientist, committed to research, in need of both advanced research training and additional experience. |
Dopamine Neurons and Heroin Reinforcement @ Indiana University Bloomington
The goal of this proposal is to provide additional training and support of the applicant under the guidance of an expert in drugs in abuse and in the laboratory well equipped for electrophysiological recording in behaving animals. The candidate has medical and biological education, and extensive experience in neurophysiology and pharmacology, including dopamine (DA) systems and addictive drugs. Because of an interruption in applicant's research career and the need for additional training and supervision, this award is critically important to support his current research position and establish his future independent career. Two advanced electrophysiological techniques, single-unit recording and iontophoresis in awake, behaving rats, are combined in the proposed project with intrevenous self-administration (SA) to assess the role of mesocorticolimbic (MCL) dopamine (DA) neurons in the development and regulation of heroin-seeking and heroin-taking behavior. Although these DA neurons, located in the ventral tegmental area (VTA), play an essential role in mediating the reinforcing properties of addictive drugs and addictive behavior, the pattern of changes in MCL DA activity during natural drug-seeking and drug-taking behavior is unknown. To provide this information, three specific aims are included in this proposal: 1. To characterize electrophysiological and receptor properties of VTA units under behaviorally relevant conditions and identify presumed DA and non-DA cells; 2. To examine the pattern(s) of impulse activity of single DA and non-DA neurons in the VTA during the performance of heroin SA behavior in trained rats; and 3. To study changes in VTA cell activity associated with the initial heroin SA and the development of drug-taking behavior (first learning sessions), as well as with passive repeated heroin administration at the same dose/pattern regimen as in the SA. These experiments will provide a better understanding of the neurochemical mechanisms regulating DA cell activity and impulse-dependent DA release under natural conditions, and will clarify the role of MCL DA cells in the development and regulation of opiate addictive behavior. A better understanding of how heroin interacts with learning and behavioral variables at the level of single VTA neurons will provide unique insights into the nature of drug craving and reinforcement.
|
0.903 |
2004 — 2018 |
Kiyatkin, Eugene A |
Z01Activity Code Description: Undocumented code - click on the grant title for more information. ZIAActivity Code Description: Undocumented code - click on the grant title for more information. |
Brain Temperature, Reward, and Drugs of Abuse @ National Institute On Drug Abuse
Our previous work revealed that psychomotor stimulant drugs such as MDMA and methamphetamine induce robust changes in brain temperature. These hyperthermic effects are strongly potentiated by social interaction and warm environment--two conditions often associated with human drug use. In this year, we worked with morphine and oxycodone--two widely used analesic opioid drugs that are widely abused and could result in lethality during overdose. We also continued our work with fentanyl and showed that even small contamination of heroin with fentanyl results in dramatic potentiation of its temperature effects. By using multi-site temperature recordings, we clarified the role of metabolic brain activation and skin vascular response in mediating temperature effects of morphine and oxycodone in wide range of doses.
|
1 |
2010 — 2018 |
Kiyatkin, Eugene A |
ZIAActivity Code Description: Undocumented code - click on the grant title for more information. |
Electrophysiological and Electrochemical Studies of Addictive Drugs @ National Institute On Drug Abuse
In this year, we were focused on two major sub-projects. First, using high-speed monitoring of EEG and EMG in freely moving rats, we demonstrated that intravenous (iv)nicotine induced rapid cortical and VTA EEG desynchronization and motor activation that occur within the time-course of injection. We also showed that a similar rapid response could be elicited by both nicotine-pirrolidine methiodide that cannot cross the blood-brain barrier. The nicotine-induced electrophysiological effects were strongly attenuated by hexamethonium, a blocker of peripheral nicotinic receptors. Therefore, it appears that rapid activation induced by iv nicotine is triggered via activation of peripheral neural substrates. We also show that the peripherally triggered effects of nicotine are conditioned and peripherally acting nicotine analogue induces conditioned behavioral and neural activation. The second sub-project, which was initiated during this year, is focused on reliable detection of glutamate (GLU) in the brain of freely moving rats. Currently, we are working to resolve several technical problems related to the use and performance of enzyme-coated electrochemical electrodes. We also examined changes in GLU levels following exposure to various environmental stimuli and intravenous cocaine. This work will be expanded during the next years to include other detected substances and the use of more complicated behavioral paradigms that involve the use of addictive drugs.
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1 |
2012 — 2016 |
Kiyatkin, Eugene A |
ZIAActivity Code Description: Undocumented code - click on the grant title for more information. |
Electrophysiological and Electrochemical Studues of Addictive Drugs @ National Institute On Drug Abuse
In this year, we were focused on two major sub-projects. First, we employed glutamate-sensitive sensors coupled with high-speed amperometry to evaluate rapid changes in glutamate following exposure to natural arousing stimuli, cocaine and nicotine. Second, we employed glucose-sensitive sensors coupled with high-speed amperometry to evaluate rapid fluctuations in brain glucose levels following exposure to natural stimuli and drugs of abuse (cocaine and nicotine). This work will be expanded during the next years to include more complicated behavioral paradigms that involve the use of addictive drugs.
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1 |