We are testing a new system for linking grants to scientists.
The funding information displayed below comes from the
NIH Research Portfolio Online Reporting Tools and the
NSF Award Database.
The grant data on this page is limited to grants awarded in the United States and is thus partial. It can nonetheless be used to understand how funding patterns influence mentorship networks and vice-versa, which has deep implications on how research is done.
You can help! If you notice any innacuracies, please
sign in and mark grants as correct or incorrect matches.
Sign in to see low-probability grants and correct any errors in linkage between grants and researchers.
High-probability grants
According to our matching algorithm, Onyekachi Odoemene is the likely recipient of the following grants.
Years |
Recipients |
Code |
Title / Keywords |
Matching score |
2015 — 2016 |
Odoemene, Onyekachi |
F31Activity Code Description: To provide predoctoral individuals with supervised research training in specified health and health-related areas leading toward the research degree (e.g., Ph.D.). |
The Role of Cortical Inhibitory Neurons in Visual Decision-Making @ Cold Spring Harbor Laboratory
? DESCRIPTION (provided by applicant): A major goal of systems neuroscience is to understand how sensory information guides behavior. The approach in our lab is to study how humans and animals make decisions about ambiguous or uncertain sensory information. The neurobiological framework of decision-making for understanding how the brain makes decisions under these conditions suggests that populations of neurons representing possible outcomes compete with one another, such that the first to reach a decision threshold is taken as the choice. These frameworks further postulate that inhibitory neurons are critical for shaping evolving decisions within a neural substrate that supports decision-making. To date there is limited experimental evidence to support the computational roles of inhibitory neurons in decision-making. The challenge towards validating this framework in experimental preparations has primarily been the availability of tools for targeting and controlling specific neural cell typs. In recent years, rodents have become exemplary models for addressing this technical hurdle. To begin to address the fundamental gap in our understanding about the neural mechanism underlying decision- making, we developed a robust and quantitative behavioral paradigm for studying decision-making in mice. In the decision task, mice make judgments about the overall rate of events occurring within a visual stimulus. We find that mice can make accurate and reliable decisions about abstract visual stimuli, and therefore suitable subjects for studying the neurobiology of decision-making. The goal of the proposed two-year research fellowship training is to understand the functional roles of cortical inhibitory neurons in the context of visual decision-making behavior. Specifically, we will independently manipulate the activity of two major classes of inhibitory neurons, parvalbumin (PV; Aim 1) and somatostatin (SOM; Aim 2) -positive neurons, in the posterior parietal cortex of mice performing a visual decision-making task. We will use behavior and extracellular recordings as readout of the optogenetic manipulation. These experiments will further define the contribution of individual subclasses of interneurons to decision-making behavior and neural activity.
|
1 |