2007 — 2008 |
Silverman, Michael |
M01Activity Code Description: An award made to an institution solely for the support of a General Clinical Research Center where scientists conduct studies on a wide range of human diseases using the full spectrum of the biomedical sciences. Costs underwritten by these grants include those for renovation, for operational expenses such as staff salaries, equipment, and supplies, and for hospitalization. A General Clinical Research Center is a discrete unit of research beds separated from the general care wards. |
Functional Neuroanatomy of Social Economic Stress @ Mount Sinai School of Medicine of Nyu
Accounting; Area; Behavioral; Biological; Brain; CRISP; Cognitive; Computer Retrieval of Information on Scientific Projects Database; Coupled; Economic Income; Economical Income; Economics; Educational process of instructing; Encephalon; Encephalons; Environmental Factor; Environmental Risk Factor; Funding; Grant; Household; Image; Immune Function, Cellular; Incentives; Income; Individual; Institution; Investigation; Investigators; Lead; Low income; Measures; Mediating; Monitoring, Physiologic; Monitoring, Physiological; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; NIH; National Institutes of Health; National Institutes of Health (U.S.); Nervous; Nervous System, Brain; Neuranatomies; Neuranatomy; Neuroanatomies; Neuroanatomy; Neuroendocrine; Neuroendocrine System; Neurosecretory Systems; Output; Pb element; Perception; Persons; Physiologic; Physiologic Monitoring; Physiological; Position; Positioning Attribute; Poverty; Premature Mortality; Prospective Studies; Psychological Stress; Research; Research Personnel; Research Resources; Researchers; Resources; Risk; Social Class; Source; Stress; Stress, Psychological; Surface; Teaching; Time; United States National Institutes of Health; biological adaptation to stress; cost; environmental risk; heavy metal Pb; heavy metal lead; imaging; immune function; incentive; inducement; neural; neural circuit; neural circuitry; neuroimaging; reaction; crisis; relating to nervous system; response; social; socioeconomic; socioeconomically; socioeconomics; stress response; stress; reaction
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0.906 |
2013 — 2014 |
Silverman, Michael Evan |
R21Activity Code Description: To encourage the development of new research activities in categorical program areas. (Support generally is restricted in level of support and in time.) |
The Epidemiology of Postpartum Depression and Associated Childhood Outcomes. @ Icahn School of Medicine At Mount Sinai
DESCRIPTION (provided by applicant): The Aims of this project are a direct answer to the mission of the NIMH to address the epidemiology of postpartum depression, to identify associated risk factors and characterize child developmental and mental health outcomes associated with clinically significant postpartum mood change. Postpartum depression is the most common complication of childbearing (Wisner KL, Chambers C, Sit D. Postpartum depression: A major public health problem. JAMA 2006~296:2616-2618), evident in approximately 11%-19% of all new mothers (Evidence Report / Technology Assessment 119. AHRQ Publication 05-E006-2). To date, most research on postpartum depression has relied on small convenience samples from clinics or hospitals that cannot generate normative data and utilize varying diagnostic criteria that more often focus on depressive symptomatology rather than clinical diagnoses of depression. This study builds on the unique resources for research on mental health available in Sweden. Linking a constellation of Swedish registers, including the National Patient Registers of health and health service utilization, National School Register, National Pharmacy Register, Total Population Register and Housing Census, we will: (a) expand upon the current knowledge base of the epidemiology of postpartum depression by more accurately describing the magnitude and pattern of clinically significant postpartum depression (hospitalized and non-hospitalized) and associated risk factors and~ (b) comprehensively characterize the child development outcomes of maternal postpartum depression. We will utilize advanced statistical methods to identify the developmental consequences of postpartum depression assessing which children of postpartum depressed mothers are more or less likely to develop problems, whether explained by maternal characteristics, such as depression timing, severity, subtypes (with and without psychosis) or comorbid conditions, child characteristics such as gender, or contextual factors such as poverty. The aims of the study are ambitious, but we have established a team of international experts with a long history of collaboration, which is well suited to address the study Aims. For predictive purposes, evaluating a comprehensive set of potential determinants of postpartum depression will generate new insights to help predict, identify, and ultimately help to prevent and treat this disorder. Because the period immediately following the birth of a child is a critica time and postpartum depression constitutes a serious threat to the infant's well-being, the epidemiologic characterization of clinically significant postpartum depression and its associated impact on childhood developmental outcomes is the first necessary step in developing adequate treatment plans.
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