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High-probability grants
According to our matching algorithm, Robert F. Furchgott is the likely recipient of the following grants.
Years |
Recipients |
Code |
Title / Keywords |
Matching score |
1985 — 1986 |
Furchgott, Robert F |
R01Activity Code Description: To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies. |
Factors Influencing Transmission At Adrenergic Synapses @ Suny Downstate Medical Center
The general objective is to elucidate the mechanisms by which local factors influence transmission at adrenergic synapses. Specific investigations will be concerned with (1) characteristics of the inhibitory presynaptic adrenergic and cholinergic receptors on adrenergic nerve terminals, and the mechanisms by which stimulation of these receptors modulates release of the neurotransmitter, norepinephrine; (2) the influx of calcium ions into the adrenergic nerve terminals associated with nerve stimulation and the subsequent release of norepinephrine, and the influence on this influx of frequency of stimulation and of drugs and agents which inhibit or potentiate norepinephrine release; (3) role of intracellular calcium in norepinephrine release; (4) mechanism of action of neuronal blocking agents such as guanethidine and bretylium; (5) the physiological reuse for exocytosis of catecholamine storage vesicles in adrenergic nerve terminals and in the adrenal medulla after they have undergone initial exocytosis. Most experiments will be carried out on perfused organs and isolated organs and tissues, some with sympathetic nerves attached and available for stimulation. Physiological, pharmacological, and biochemical approaches will be employed. Use will be made of radioactive-labeled compounds when appropriate.
|
0.916 |
1985 — 1997 |
Furchgott, Robert F |
R01Activity Code Description: To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies. R37Activity Code Description: To provide long-term grant support to investigators whose research competence and productivity are distinctly superior and who are highly likely to continue to perform in an outstanding manner. Investigators may not apply for a MERIT award. Program staff and/or members of the cognizant National Advisory Council/Board will identify candidates for the MERIT award during the course of review of competing research grant applications prepared and submitted in accordance with regular PHS requirements. |
Mechanisms of Action of Vasodilator Agents @ Suny Downstate Medical Center
The original objective of this project is to characterize by pharmacological and biochemical methods the adrenergic receptors in selected sympathetically innervated tissues in order to improve our understanding of factors at the receptor level which regulate the responses of these tissues to various adrenergic drugs and to sympathetic nerve stimulation. Experiments will be carried out (1) to ascertain whether the simultaneous occurrence of more than one type of adrenergic beta-receptor in a single cell type is a common phenomenon; (2) to elucidate the factors which control the variable ratio of beta1-to beta2-type receptors in selected smooth muscle cells; (3) to reexamine whether postjunctional adrenergic alpha-receptors in different sympathetic effectors in the same species are all of a single type. Characterization of receptors responsible for mediating a specific response in a given isolated tissue will be carried out by determining with appropriate pharmacological procedures affinities and efficacies of selected agonists, and affinities of selected competitive antagonists. In addition, we shall apply radioactive ligand-binding techniques for quantification of one or more types of beta-receptors or alpha-receptors in selected tissues. In addition to the original objective, a new major objective is to elucidate the mechanism by which acetylcholine relaxes blood vessels. We have already demonstrated with isolated vessels that this relaxation is the result of acetylcholine acting on the muscarinic receptors of endothelial cells, which then are stimulated to produce and release a substance that relaxes the smooth muscle cells. Pharmacological and biochemical studies will be directed at determining the nature of released relaxing substance and the mechanism whereby it activates relaxation.
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0.916 |