2005 — 2007 |
Allison, Jeroan J |
R18Activity Code Description: To provide support designed to develop, test, and evaluate health service activities, and to foster the application of existing knowledge for the control of categorical diseases. |
Internet Intervention For Improving Rural Diabetes Care @ University of Alabama At Birmingham
DESCRIPTION (provided by applicant): Background. The prevalence of diabetes in Alabama has increased to 10.5 %, one of the highest among all states. We propose a 4-year randomized trial of an Internet-based intervention for improving guideline adherence by rural Alabama physicians caring for adult patients with type 2 diabetes. Rural Alabama has many disadvantaged and minority patients with limited health care access. Patients with diabetes in rural Alabama receive poorer quality of care and have worse outcomes compared to urban patients. Objectives. (1) Assess barriers to implementation of diabetes guidelines and identify solutions through focus groups and case-based vignette surveys; (2) Develop and implement an interactive Internet intervention including individualized physician performance feedback; (3) Evaluate the intervention in a randomized controlled trial; and (4) Examine the sustainability of improved guideline adherence once feedback ceases. Methods. In partnership with the University of Alabama rural medicine program, we will randomize 200 rural physician offices to an intervention or comparison arm. Our 18-month intervention, customized to the individual physician in real-time, consists of Internet learning modules with case-based education, performance feedback, and benchmarks. The comparison group will receive a text-based, non-interactive Internet posting of publicly available resources. Nurse practitioners and physician assistants from the offices of study physicians may also participate in the Internet modules. Outcomes will be based on previously developed and validated quality measures for diabetes. The intervention will cover screening, diagnosis, treatment, and prevention. Performance feedback will include 15 charts per intervention physician. The main analysis, conducted at the physician level, will compare differential improvement in guideline adherence between the study arms. Ancillary analyses will examine the effects of physician characteristics, other providers in the office, and patient characteristics (e.g., comorbidities, ethnicity, gender, age, and socioeconomic status). Multivariable techniques will adjust for repeated measures, clustering of patients within physicians, and multiple providers within a single office. Significance. This study offers a technologically advanced, theory-grounded intervention for improving care of a high-risk, underserved population. With expertise in translating research into practice, rural medicine, behavioral medicine, health informatics, and clinical diabetes, our multidisciplinary team has a proven record of collaboration. This project will produce an evidence-based and replicable intervention that can be sustained in the "real world," and easily modified for other diseases. This project is substantially improved after making important changes recommended in the second review.
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0.994 |
2012 — 2016 |
Allison, Jeroan J |
P60Activity Code Description: To support a multipurpose unit designed to bring together into a common focus divergent but related facilities within a given community. It may be based in a university or may involve other locally available resources, such as hospitals, computer facilities, regional centers, and primate colonies. It may include specialized centers, program projects and projects as integral components. Regardless of the facilities available to a program, it usually includes the following objectives: to foster biomedical research and development at both the fundamental and clinical levels; to initiate and expand community education, screening, and counseling programs; and to educate medical and allied health professionals concerning the problems of diagnosis and treatment of a specific disease. |
Administrative Core @ Univ of Massachusetts Med Sch Worcester
Our proposed Center for Health Equity Intervention Research (CHEIR) is the product of inter-disciplinary collaboration among researchers, educators, and community activists at the Boston and Worcester campuses of the University of Massachusetts, seamlessly woven together through a broad-based plan to eliminate health disparities. CHEIR will leverage existing resources available through our NIH-funded Clinical and Translational Science Award, our CDC-funded Worcester County Prevention Research Center, several units at the two participating UMass campuses, and three ethnic centers: the Gaston Institute for Latino Community Development and Public Policy, the William Monroe Trotter Institute for the Study of Black Culture, and the New England Institute for Native American Studies. Our Specific Aims are to: (1) Generate collaboration and synergy by effectively managing CHEIR resources, investigator and community networking, enrichment activities, and dissemination of research findings; (2) Ensure CHEIR meets all stated goals by coordinating the regular and systematic monitoring of each component and the overall center using the CHEIR Logic Mode; (3) Conduct two high-profile Synthesis, Engagement, and Elevation to Eliminate Disparities (SEED) Symposia (Years 3 and 5); and (4) Engage in vigorous outreach activities, including collaboration with other NCMHD Centers of Excellence, and through multiple venues such as the Internet Dissemination Depot. Drawing on cutting-edge developments in organizational development, the SEED Symposia will: (1) Synthesize a vast array of data from our CHEIR faculty, students, and communities; (2) Generate new findings and resources to eliminate health disparities;and (3) Map a clear path forward as we refine our center's mission and vision CHEIR reflects the combined talent of ethnically diverse, accomplished, and inter-disciplinary researchers devoted to working with under-served populations. Although the Administrative Core will manage routine activities, such as day-to-day operations and resource allocation, it offers scientific innovation through activities such as the SEED Symposia and the Internet Dissemination Depot.
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0.969 |
2012 — 2016 |
Allison, Jeroan J |
P60Activity Code Description: To support a multipurpose unit designed to bring together into a common focus divergent but related facilities within a given community. It may be based in a university or may involve other locally available resources, such as hospitals, computer facilities, regional centers, and primate colonies. It may include specialized centers, program projects and projects as integral components. Regardless of the facilities available to a program, it usually includes the following objectives: to foster biomedical research and development at both the fundamental and clinical levels; to initiate and expand community education, screening, and counseling programs; and to educate medical and allied health professionals concerning the problems of diagnosis and treatment of a specific disease. |
Umass Center For Health Equity Intervention Research @ Univ of Massachusetts Med Sch Worcester
The Center for Health Equity Intervention Research (CHEIR) is the product of inter-disciplinary collaboration among researchers, educators, and community activists, seamlessly woven through a broadbased plan to eliminate health disparities. CHEIR components (education, research, and community engagement) support each other for the attainment of their respective aims. CHEIR faculty will: (1) implement three specific research projects; (2) provide expert consultation for developing culturally and linguistically responsive interventions; (3) provide biostatistical and data management resources; (4) nurture junior scientists with high-potential nascent ideas; (5) respond to existing community interest and need by increasing research literacy and engagement in research; and (6) provide formal and service-oriented training opportunities to the next generation of health disparity researchers, creating a diverse workforce. We will leverage existing resources available through our Clinical and Translational Science Award, our Prevention Research Center, and three minority institutes (the Gaston Institute, the William Monroe Trotter Institute and the Institute for New England Native American Studies). The Specific Aims of the Administrative Core are to: (SA1) Generate collaboration and synergy by effectively managing center membership, investigator and community networking, enrichment activities such as conferences and workshops, and dissemination of CHEIR activities and research findings; (SA2) Ensure CHEIR meets all stated goals by regular and systematic monitoring of each component and the overall center using the LOGIC model; (SAS) Conduct two high-profile Synthesis, Engagement, and Elevation to Eliminate Disparities (SEED) Symposia that (1) synthesize our progress to date from a holistic perspective; (2) solidify our engagement with faculty, students, and community; and (3) elevate our work to the next level by mapping the course forward and best positioning CHEIR to fulfill and sustain its ongoing mission; and (SA4) Engage in outreach activities, including collaboration with other NCMHD Centers of Excellence, and through multiple venues such as the Internet Dissemination Depot.
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0.969 |
2014 — 2015 |
Allison, Jeroan J |
R21Activity Code Description: To encourage the development of new research activities in categorical program areas. (Support generally is restricted in level of support and in time.) |
We Talk About Our Hypertension @ Univ of Massachusetts Med Sch Worcester
DESCRIPTION (provided by applicant): Although being a low-middle income country, Vietnam has been experiencing an epidemiologic transition to that of a developing country with an increasing prevalence of non-communicable diseases. The key risk factors for cardiovascular disease (CVD) are either on the rise or at alarming levels in Vietnam, particularly hypertension (HTN). Inasmuch, the burden of CVD will continue to increase in Vietnamese men and women unless effective prevention and control measures are put in place. The objectives of the proposed project are to develop a multi-faceted community-based intervention, based on a Storytelling method which has been shown to be effective in other minority populations, for the control of elevated blood pressure (BP) in adults in Vietnam. We are proposing a pilot cluster-randomized trial to test the feasibility of a large scale effectiveness trial. Four communities (wih a total of 100 hypertensive patients) will be randomized into either an intervention (n=2) or comparison group (n=2) (matching on population size); persons with HTN will be randomly assigned to intervention or control status based on their community of residence. Eligible and consenting participants in the intervention group will receive culturally and literacy appropriate HTN related educational materials and in-person sessions through viewing DVDs of stories from patients with HTN (Storytelling) given by trained health workers. The DVDs will include stories about the health consequences of uncontrolled HTN, overcoming barriers to HTN control, and adherence to prescribed medication and lifestyle changes. Primary health care providers in the intervention communities will also be empowered through intensive training and education on HTN control. In communities assigned to usual care, persons will view comparison DVDs, which only contain guidelines on HTN, and will be in a non-interactive format without storytelling or supplementary materials, and receive HTN related education as currently provided at local community health centers. This project addresses a serious clinical and public health problem in Vietnam by implementing the first community-based study using a culturally-literacy appropriate HTN intervention for this population.
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0.969 |
2015 — 2018 |
Allison, Jeroan J Cdc Default Person, Cdc Default Person Moore Simas, Tiffany Anne |
U01Activity Code Description: To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies. |
Rapid Access to Perinatal Psychiatric Care in Depression Program (Rappid): An Innovative Stepped-Care Approach For Obstetrics and Gynecology Clinics @ Univ of Massachusetts Med Sch Worcester |
0.969 |
2015 — 2018 |
Allison, Jeroan J Keaney, John F. |
KL2Activity Code Description: Undocumented code - click on the grant title for more information. |
University of Massachusetts Center For Clinical and Translational Science @ Univ of Massachusetts Med Sch Worcester
KL2 Project Summary/Abstract We propose our second generation institutional translational KL2 program at the University of Massachusetts Worcester Campus (UMW) that consists of the UMass Medical School (UMMS), the Graduate School of Biomedical Sciences (GSBS), and the Graduate School of Nursing (GSN). This program will build upon the transformative KL2 program that has produced 9 scholars with three graduates who together, have had an outstanding impact on our campus and patient care. This program will encompass the full spectrum of translational research from first-in-man studies to implementation science and global health with additional continuous feedback to our basic science colleagues. Working across the University of Massachusetts (UMass) system, we will leverage applied science, engineering, and manufacturing resources to foster a collective institutional culture of creativity and collaboration driving scientific inquiry across disciplinary boundaries. The nature of this proposal is transdisciplinary, a term we have adopted to describe a working environment that expands beyond discipline-based concepts, theories, and methods as a means to address a common research topic and promote team science. In this program, we aim to: 1. Promote a research career development program across basic, clinical, and population health disciplines geared towards translating research into effective clinical practice and policy, as well as generating new questions spanning the entire spectrum of research. 2. Recruit promising scholars resulting in a diverse scholar pool with respect to sociodemographic characteristics, clinical background, and disciplinary perspective. 3. Provide scholars with the individual mentoring, academic career development, and technical skills necessary to ensure their success as independent investigators as well as contributors to team science. 4. Provide an independence-targeted research experience within transdisciplinary teams that builds on the strengths of the current environment of linkages between UMass campuses, departments, centers, and institutes. In order to achieve these aims, each scholar will pursue a major research theme with guidance and direction from an experienced lead mentor and transdisciplinary mentorship team. Scholars will also pursue a degree or coursework to enhance their research potential, and undergo a novel high-impact journal internship that will position them to submit their results for publication in a practice-changing journal. Finally, scholars will produce an R01-level grant under the guidance of both their mentorship team and our newly created ?K to R Club? to position them for independence. Consistent with our transdisciplinary approach, our proposed program also includes mentor development that is built into our mentoring teams across the continuum of faculty levels and disciplinary perspectives. Thus, this program represents a UMass-wide effort for the next generation of our already transformative translational investigator career development program. Using these novel training paradigms and the plans laid out in this proposal, we will be able to meet the current and future needs of translational investigation in Central Massachusetts and beyond.
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0.969 |
2016 — 2020 |
Allison, Jeroan J Harris, Paul A. Lemon, Stephenie C. Saag, Kenneth G (co-PI) [⬀] |
U01Activity Code Description: To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies. |
Strengthening Translational Research in Diverse Enrollment (Stride) @ Univ of Massachusetts Med Sch Worcester
ABSTRACT The goal of STRIDE (Strengthening Translational Research in Diverse Enrollment) is to develop, test, and disseminate an integrated multi-level, culturally sensitive intervention to engage African Americans and Latinos in translational research. STRIDE is a partnership of the CTSAs at the University of Massachusetts Medical School, the University of Alabama at Birmingham, and Vanderbilt University, three geographically diverse areas with large numbers of African American and Latino constituents. Despite disparities in leading causes of death, morbidity and disability, African Americans and Latinos are under-represented in important translational research studies that have potential to reduce these disparities. Our team's prior work suggests that limited research literacy, defined as ?the capacity to obtain, process and understand basic information needed to make informed decisions about research participation,? often precludes research participation. Participant barriers also include lack of trust stemming from historical abuses. Research team members often lack skills in cultural competency and may not be sensitive to important issues faced by populations of color. Likewise, informed consent procedures contained within the research system may create confusion and disengagement of diverse participants. The multilevel STRIDE intervention will address these barriers at three levels: patient, research team, and system. The STRIDE intervention builds from synergistic work conducted at the three participating CTSA hubs that includes patient, research staff and systems (e-Consent) targeted interventions. Collectively, our approach will enable research personnel to recruit and deliver informed consent in a culturally competent, literacy appropriate manner, while also improving the ?research literacy? of potential research participants. The participant component of the STRIDE intervention will draw upon the power of narrative intervention, or ?storytelling,? by harnessing powerful stories from actual research participants describing their experiences, which will be incorporated in community-based outreach forums, the e-consent platform and in clinical settings. The research team component of the STRIDE intervention centers on an innovative application of medical simulation to improve the cultural competency of those recruiting and enrolling diverse participants in translational research. The systems component of the STRIDE intervention will be based on an innovative REDCap e-Consent platform adapted for cultural sensitivity to African American and Latinos and incorporates access to ancillary tools to enhance patient understanding. The project has three Specific Aims that correspond to three study phases. In Aim 1, the comprehensive intervention will be developed and pilot tested. In Aim 2, a multi-site interrupted time series design trial will be conducted to determine the impact of the STRIDE intervention on recruitment of African American and Latino participants in ongoing clinical trials. In Aim 3, dissemination activities will be conducted throughout the CTSA network and beyond.
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0.969 |
2017 — 2019 |
Allison, Jeroan J Ha, Duc Anh Tran, Oanh |
U01Activity Code Description: To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies. |
???Ng ??U V?I B?Nh T?Ng Huy?T áP ? Vi?T Nam: Gi?I PháP T? Y T? C? S?. (Conquering Hypertension in Vietnam: Solutions At Grassroots Level) @ Health Strategy and Policy Institute
PROJECT SUMMARY/ABSTRACT Although being a low-middle income country, Vietnam has been experiencing an epidemiologic transition to that of a developing country with an increasing prevalence of non-communicable diseases. The key risk factors for cardiovascular disease (CVD) are either on the rise or at alarming levels in Vietnam, particularly hypertension (HTN). Inasmuch, the burden of CVD will continue to increase in Vietnamese men and women unless effective prevention and control measures are put in place. The objectives of the proposed project are to evaluate the implementation and effectiveness of two multi-faceted community and clinic-based strategies on the control of elevated blood pressure (BP) among adults in Vietnam via a cluster-randomized trial design. Sixteen communities will be randomized to either an intervention (8 communities) or comparison group (8 communities). Eligible and consenting adult study participants with HTN (n = 600) will be assigned to intervention/comparison status based on the community in which they reside. Both comparison and intervention groups will receive a multi-level intervention modeled after the Vietnam National Hypertension Program. Components of this program include education and practice change modules for health care providers, accessible reading materials for patients, and a community awareness multi-media program. In addition to the Vietnam National Hypertension Program, the intervention group only will receive three carefully selected enhancements integrated into routine clinical care: (1) expanded community health worker services; (2) home BP self-monitoring; and (3) a ?storytelling intervention,? previously developed and pilot tested for feasibility and effectiveness by the research team. The storytelling intervention consists of interactive, literacy-appropriate, and culturally sensitive multimedia storytelling modules for motivating behavior change through the power of patients speaking in their own voice. Based on preferences that emerged during our formative work with our partnering rural communities, the storytelling intervention will be delivered by DVD, with serial installments at baseline and at 3, 6, and 9 months after trial enrollment. Changes in BP will be assessed in both study groups at several follow-up time points. We will pursue a multi-faceted strategy to support implementation of the Vietnam National Hypertension Program and the proposed enhancements. In conjunction with the work done during the pilot feasibility study, current efforts by the Vietnam National Hypertension Program, and the proposed investigation, this project addresses a serious clinical and public health problem in Vietnam by implementing the first community-based study using a culturally- literacy appropriate HTN intervention for this population.
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0.904 |
2019 — 2021 |
Allison, Jeroan J An, Dao Thi Minh Nguyen, Hoa (co-PI) [⬀] |
D43Activity Code Description: To support research training programs for US and foreign professionals and students to strengthen global health research and international research collaboration. |
Training Program For Strengthening Research Capacity in Non-Communicable Diseases in Vietnam (Tsorc-Ncds-Vn) @ Hanoi Medical University
We are proposing a 5 year training program entitled ??Training Program for Strengthening Research Capacity in Non-Communicable Diseases in Vietnam.? Vietnam has been facing an increasing burden from non-communicable diseases (NCDs) over the last several decades, with especially notable increases in the morbidity and mortality from cardiovascular disease (CVD), cancer, chronic lung disease, and diabetes; CVD now represents the leading cause of death in Vietnam, accounting for approximately one third of all deaths. Despite the magnitude and impact of NCDs, research capacity in NCDs in Vietnam is still limited and faces numerous challenges. Vietnam urgently needs to strengthen its research capacity in the clinical and population health sciences and develop research training programs that emphasize innovative strategies for disease prevention. As a starting point to address this ongoing need, our multi-disciplinary team received support from the NIH Fogarty Center to engage in an intensive needs assessment and planning process during the past year. The proposed training programs and educational offerings, and the accompanying mentored research experiences, flow from a broad-based and detailed data collection and synthesis that engaged faculty and students at Hanoi Medical University (HMU) and key partners from the Vietnam Ministry of Health. The proposed training program is built upon a robust and rapidly expanding program of extramurally funded research, with joint leadership from Vietnam and University of Massachusetts Medical School (UMMS) investigators. The planning process has also been critically informed by several currently NIH-funded UMMS training programs including T32 and KL2. Our Specific Aims are to: Aim 1. Develop a research and training program in Non-Communicable Diseases that fits Vietnam's needs and resources as articulated by the Vietnam Ministry of Health: (a) Establish a new Postdoctoral Fellowship program that will equip early-stage investigators to establish themselves as independent, extramurally funded scientists; (b) Establish a new Clinical Research Scholars Training Program that will provide clinicians with the research tools necessary to leverage their clinical training and experience to design and carry out high quality research studies that address pressing problems in clinical and population health, with an emphasis on national policy relevance and publication in international journals; (c) Based on models that have been successfully implemented at the UMMS, develop new research methods courses that would be offered to non-degree and degree students and would be made available to students, physicians, nurses, and clinical investigators. Aim 2. Establish a Center of Excellence in Non-Communicable Diseases Research at HMU: (a) Building upon formal recommendations issued by the Vietnamese Ministry of Health as part of the year-long planning process, inaugurate the newly proposed Center of Excellence with strong institutional commitments of HMU and HMU hospital; (b) Implement an administrative structure that will allow the center to provide easily accessible resources for research methodology and data management, enable transdisciplinary relationships across departments, institutes, centers, and the clinical system, and provide linkages and critical support for longitudinal mentoring relationships among program trainees; (c) Solidify collaboration with the Vietnam Ministry of Health to align the research agenda and training approach with contemporary needs in CVD prevention and treatment to support the national implementation of evidence-based policy measures. Our international multi-disciplinary team has expertise in designing and conducting clinical and population-based research studies and in developing successful research training programs. Our team includes high-ranking and accomplished scientists from the Vietnam Ministry of Health who are serving in leadership roles as part of our current NIH funded work. For several currently NIH funded clinical trials, the Ministry of Health has formally committed to sustaining newly developed and proven interventions as part of the national public health infrastructure. The environment and resources offered by this proposal provide an unprecedented opportunity to strengthen research capacity in NCD research with a measurable health impact at the national level.
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0.979 |
2020 — 2021 |
Allison, Jeroan J Ha, Duc Anh Tran, Oanh |
U01Activity Code Description: To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies. |
Conquering Hypertension in Vietnam: Solutions At Grassroots Level @ Health Strategy and Policy Institute
PROJECT SUMMARY/ABSTRACT Although being a low-middle income country, Vietnam has been experiencing an epidemiologic transition to that of a developing country with an increasing prevalence of non-communicable diseases. The key risk factors for cardiovascular disease (CVD) are either on the rise or at alarming levels in Vietnam, particularly hypertension (HTN). Inasmuch, the burden of CVD will continue to increase in Vietnamese men and women unless effective prevention and control measures are put in place. The objectives of the proposed project are to evaluate the implementation and effectiveness of two multi-faceted community and clinic-based strategies on the control of elevated blood pressure (BP) among adults in Vietnam via a cluster-randomized trial design. Sixteen communities will be randomized to either an intervention (8 communities) or comparison group (8 communities). Eligible and consenting adult study participants with HTN (n = 600) will be assigned to intervention/comparison status based on the community in which they reside. Both comparison and intervention groups will receive a multi-level intervention modeled after the Vietnam National Hypertension Program. Components of this program include education and practice change modules for health care providers, accessible reading materials for patients, and a community awareness multi-media program. In addition to the Vietnam National Hypertension Program, the intervention group only will receive three carefully selected enhancements integrated into routine clinical care: (1) expanded community health worker services; (2) home BP self-monitoring; and (3) a ?storytelling intervention,? previously developed and pilot tested for feasibility and effectiveness by the research team. The storytelling intervention consists of interactive, literacy-appropriate, and culturally sensitive multimedia storytelling modules for motivating behavior change through the power of patients speaking in their own voice. Based on preferences that emerged during our formative work with our partnering rural communities, the storytelling intervention will be delivered by DVD, with serial installments at baseline and at 3, 6, and 9 months after trial enrollment. Changes in BP will be assessed in both study groups at several follow-up time points. We will pursue a multi-faceted strategy to support implementation of the Vietnam National Hypertension Program and the proposed enhancements. In conjunction with the work done during the pilot feasibility study, current efforts by the Vietnam National Hypertension Program, and the proposed investigation, this project addresses a serious clinical and public health problem in Vietnam by implementing the first community-based study using a culturally- literacy appropriate HTN intervention for this population.
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0.904 |