1985 |
Gibson, Robert W |
R01Activity Code Description: To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies. |
Epidemiology of All/Nhl in Children Under 16 @ University of Minnesota Twin Cities
The proposed study will investigate the relation between environmental exposures in susceptible hosts and the subsequent risks for development acute lymphatic leukemia (ALL) and non-Hodgkin's lymphomas (NHL) among children less than 16 years of age. The investigation will focus upon multiple exposures, both environmental and biologic, in the lives of the index subjects themselves, as well as the lives of their parents prior to the index subject's birth. The primary investigation will utilize laboratory and epidemiologic techniques to characterize cases/controls and in some instances, members of their families, to test the following hypotheses: 1) To determine if family members of patients with particular immunologic subsets of acute lymphoblastic leukemia or non-Hodgkin's lymphoma, specifically B or pre-B (antibody producing) cell disease have a high incidence of autoimmune phenomena than families of matched controls. In addition to ascertaining family histories of clinically apparent autoimmune disease, specific cellular and serum determinations will be made including: fluorescent antinuclear antibody(FANA), quantitation of suppressor and helper T-cells and complement levels. 2) To assess if there exists an association between specific environmental exposures and chromosomal abnormalities in the leukemia cases through a comparison of exposed cases with nonexposed cases. Cytogenetic information will be ascertained from banded karyotype studies of diagnostic bone marrow samples. 3) Molecular hybridization techniques will be utilized to determine the presence of BLV particles in the marrow of cases only and the peripheral blood of the cases and controls. DNA hybridization studies of cases will be performed on pretreatment specimens. 4) To determine the pattern of enteraction between environmental exposures and host characteristics. Epidemiologic factors include ionizing radiation, animals, occupational exposures of parents and disease histories of family members including parents, siblings, and grandparents. Quantification of the risks associated with these exposures will be made by contrasting the cases of acute lymphoblastic leukemia and non-Hodgkin's lymphomas to a set of age-, sex-, and race-matched regional population controls.
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0.919 |
1987 |
Gibson, Robert W |
R01Activity Code Description: To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies. |
Epidemiology of All/Nhl in Children <16 Years of Age @ University of Minnesota Twin Cities
The proposed study will investigate the relation between environmental exposures in susceptible hosts and the subsequent risks for development acute lymphatic leukemia (ALL) and non-Hodgkin's lymphomas (NHL) among children less than 16 years of age. The investigation will focus upon multiple exposures, both environmental and biologic, in the lives of the index subjects themselves, as well as the lives of their parents prior to the index subject's birth. The primary investigation will utilize laboratory and epidemiologic techniques to characterize cases/controls and in some instances, members of their families, to test the following hypotheses: 1) To determine if family members of patients with particular immunologic subsets of acute lymphoblastic leukemia or non-Hodgkin's lymphoma, specifically B or pre-B (antibody producing) cell disease have a high incidence of autoimmune phenomena than families of matched controls. In addition to ascertaining family histories of clinically apparent autoimmune disease, specific cellular and serum determinations will be made including: fluorescent antinuclear antibody(FANA), quantitation of suppressor and helper T-cells and complement levels. 2) To assess if there exists an association between specific environmental exposures and chromosomal abnormalities in the leukemia cases through a comparison of exposed cases with nonexposed cases. Cytogenetic information will be ascertained from banded karyotype studies of diagnostic bone marrow samples. 3) Molecular hybridization techniques will be utilized to determine the presence of BLV particles in the marrow of cases only and the peripheral blood of the cases and controls. DNA hybridization studies of cases will be performed on pretreatment specimens. 4) To determine the pattern of enteraction between environmental exposures and host characteristics. Epidemiologic factors include ionizing radiation, animals, occupational exposures of parents and disease histories of family members including parents, siblings, and grandparents. Quantification of the risks associated with these exposures will be made by contrasting the cases of acute lymphoblastic leukemia and non-Hodgkin's lymphomas to a set of age-, sex-, and race-matched regional population controls.
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0.919 |
1988 — 1993 |
Gibson, Robert |
N/AActivity Code Description: No activity code was retrieved: click on the grant title for more information |
Experimental Analysis of Natural Choice Behavior @ University of California-Los Angeles
The sage grouse is one of the more popular game birds in the western United States and a major spectacle viewed by thousands of the public each spring. Its management is one of the important duties of state fish and game departments. Dr. Gibson and his colleagues have conducted basic research that has provided a number of tools useful in this management. These useful findings have emerged from research using the sage grouse as a model system to examine theoretical questions about the mechanisms that determine biased mating success. Males of lek-mating species exhibit conspicuous behaviors that attract females and thereby secure reproductive opportunities for the males. Female sage grouse choose a mate from a group (or lek) of communally displaying males. This study will investigate experimentally the role played by the vocal courtship display of male sage grouse. The effects of vocal signals on female choice will be studied in the field by temporarily muting certain males and comparing their subsequent mating success with that of males that have not been muted. The study will test hypotheses derived from previous observational studies of this species. The results will be directly relevant to the wider issue of the role played by female mating preferences in the evolution of courtship behavior.
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0.961 |
2009 — 2013 |
Gibson, Robert William |
P20Activity Code Description: To support planning for new programs, expansion or modification of existing resources, and feasibility studies to explore various approaches to the development of interdisciplinary programs that offer potential solutions to problems of special significance to the mission of the NIH. These exploratory studies may lead to specialized or comprehensive centers. |
Community Engagement/Outreach Core @ Georgia Regents University
This core contains four projects, each of which involves outreach and interaction with the Sickle Cell community. The projects described in this core involve the SC community in both the development and evaluation of effective treatments/interventions that reduce health disparities in the treatment of SCO. The interaction with the SC community is integral to the success of each of these projects. The projects are:1) The provision of adequate treatment for pain crisis in the ER, 2) Health care transition preparation for young people with SCO moving from pediatric to adult oriented care, 3) The establishment and evaluation of an Advance Medical Home for patients with SCO and 4) A science camp/university experience for high school age young people with SCO to learn about the science and scientists developing treatments for SCO.
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0.901 |
2009 — 2013 |
Gibson, Robert William Kutlar, Abdullah |
P20Activity Code Description: To support planning for new programs, expansion or modification of existing resources, and feasibility studies to explore various approaches to the development of interdisciplinary programs that offer potential solutions to problems of special significance to the mission of the NIH. These exploratory studies may lead to specialized or comprehensive centers. |
Mu Opioid Polymorphisms as Genetic Modifiers of Pain and Opioid Use In @ Georgia Regents University
Vasoocclusive episodes (VOE; painful crises) are a well-known hallmark of sickle cell disease (SCD) and are responsible for the vast majority of health care encounters. There is significant heterogeneity in the frequency of VOE (acute pain) among these patients. SCD patients also experience chronic pain due to complications such as avascular necrosis and leg ulcers. While some of this heterogeneity can be explained by well known genetic modifiers, such as the hemoglobin F, there is a large number of patients in whom there is a lack of a clear-cut explanation for this variation. Opioids form an important component of the management of acute and chronic pain in patients with SCD. Chronic opioid use, sometimes associated with dependence and addiction in a subset of patients, may pose difficult management problems. This coupled with a general lack of adequate knowledge of the management of pain and the fear of addiction often results in under-treatment of painful conditions. The Mu opioid receptor (OPRM1) is the primary site of action of endogenous opioid peptides and opioid analgesics. Recent data indicate that polymorphisms in the OPRM1 gene as well as other genes (COMT, PTGS1, PTGS2, SLC6A4, SCN9A) are associated with differences in pain threshold and narcotic requirements. This study will test the hypothesis that variations in these genes act as genetic modifiers influencing pain frequency, intensity, threshold, opioid usage and dose requirement, as well as opioid dependency. This will be achieved by 1) a prospective analysis of frequency of VOE, pain diaries, and total opioid usage, 2) a prospective data collection consisting of frequency of hospitalizations with VOE, narcotic usage during a hospitalized VOE, evolution of pain scores, and length of hospital stay and correlation of these data with genetic variation in the aforementioned genes, and 3) an experimental component of testing pain threshold with a pressure pain algometer. It is anticipated that genetic correlates of pain frequency and opioid dose requirements will be determined and will lead to individualization of the management of pain in patients with SCD.
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0.901 |
2009 — 2013 |
Gibson, Robert William Kutlar, Abdullah |
P20Activity Code Description: To support planning for new programs, expansion or modification of existing resources, and feasibility studies to explore various approaches to the development of interdisciplinary programs that offer potential solutions to problems of special significance to the mission of the NIH. These exploratory studies may lead to specialized or comprehensive centers. |
Ncmhd Southeastern Exploratory Sickle Cell Center of Excellence @ Georgia Regents University
DESCRIPTION: Sickle cell disease (SCD) is a genetic disorder of hemoglobin and afflicts ~110,000 African-Americans in the US. Because of its complex pathophysiology through chronic hemolytic anemia, microvascularocclusion, and a chronic inflammatory state, it affects multiple organ systems and leads to significant morbidity and organ damage as well as leads to frequent hospitalizations and health care encounters. During the past 35 years, primarily through research and patient care conducted by the NIH funded Comprehensive Sickle Cell Centers and some pivotal clinical trials, the life expectancy of patients with SCD has increased from the teens to mid- to late forties. This is still considerably shorter than that of African-Americans who do not have sickle cell disease and can be viewed as a major disparity even in this underserved minority population. While significant advances have been made in the understanding of the disease pathophysiology and in novel therapies through basic and translational research, these advances have been slow to be taken to clinical practice. The Southeastern Exploratory Sickle Cell Center of Excellence seeks to improve the care and quality of life of the SCD patient population by i) investigating the basic mechanism of action of a highly successful and effective hemoglobin F inducing drug, hydroxyurea, ii) identifying genetic variations underlying the frequency of pain, response to narcotics, and thus addressing the important issue of biologic/genetic bases of pain and its under treatment leading to the stigmatization of many SCD patients and its resulting disparity, iii) investigating the medical, social, and economic reasons for underutilization of hydroxyurea in SCD, iv) training primary care physicians with evidence based medicine in the care of patients with SCD, given the sobering reality that there will not be enough specialists in non-malignant hematology to meet the needs of the growing adult SCD population, and v) implementing innovative methods and concepts for the care of SCD patients in the ED and for transitioning from pediatric to adult care. Relieving the health disparity of SCD patients is the primary goal of this application.
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0.901 |
2016 — 2021 |
Gibson, Robert William Kutlar, Abdullah |
U01Activity Code Description: To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies. |
Implementation of Medical Homes For Evidence Based Care of Adolescents and Adults With Sickle Cell Disease
Scope of Work: Tilicia L. Mayo-Gamble Proposal Title: Minority Supplement Sponsor: National Heart, Lung, and Blood Institute Task: Dr. Mayo-Gamble (Georgia Southern University), will conduct supplemental aims to Dr. Abdullah Kutlar?s (Augusta University Medical Center) parent award 5U01HL134004-03, Implementation of Medical Homes for Evidence Based Care of Adolescents and Adults with Sickle Cell Disease. Dr. Mayo-Gamble will: 1) assess the feasibility of integrating a community health worker (CHW) into a PCCC team for SCD; 2) evaluate the efficacy of enhanced care coordination using an integrated PCCC-CHW model, on patient satisfaction with medical care, self-care behaviors, and clinical outcomes; and 3) determine the acceptability of the intervention and protocol among patients and care team members through semi-structured interviews. Dr. Mayo-Gamble will work closely with her mentors (Dr. Kutlar and Dr. Telfair) to implement her career development plan and execute the research project. She will also engage in didactic and experiential training in sickle cell community-based and clinical research, participate in professional development activities, and conduct the aims of the supplemental research proposal through the guidance of her mentoring team and scientific advisory committee. Dr. Mayo-Gamble will be responsible for maintaining communication with mentors and all stakeholders. Deliverables: Dr. Mayo-Gamble will contribute authorship in the preparation of journal manuscripts for publication in interdisciplinary journals and presentation at a professional conference. She will also contribute to reports to be submitted to NHLBI including the mid- project report and the final project report.
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0.914 |