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High-probability grants
According to our matching algorithm, Catherine Fassbender is the likely recipient of the following grants.
Years |
Recipients |
Code |
Title / Keywords |
Matching score |
2012 |
Fassbender, Catherine |
R03Activity Code Description: To provide research support specifically limited in time and amount for studies in categorical program areas. Small grants provide flexibility for initiating studies which are generally for preliminary short-term projects and are non-renewable. |
Identifying Cognitive and Neural Risk Factors For Substance Dependence in Adhd @ University of California At Davis
DESCRIPTION (provided by applicant): Among adults seeking treatment for methamphetamine (MA) dependence there is a high prevalence of Attention Deficit/Hyperactivity Disorder (ADHD). Many studies in MA subjects do not screen for ADHD, thus the synergistic interaction between ADHD and MA dependence has not been systematically examined. The proposed project will employ functional neuroimaging and targeted measures of cognition to assess behavioral and neural impairments in cognitive control associated with both ADHD and MA dependence. The goal is to identify the unique contributions of each clinical disorder as well as a functional signature of ADHD+MA comorbidity. Although there has been research into reward and motivational factors in both ADHD and substance dependence, the role of cognitive control and behavioral regulation is under-investigated. Comorbidity of ADHD and stimulant abuse is of particular interest, as stimulants are a preferred treatment for ADHD. Individuals with ADHD display a wide range of cognitive control deficits; however, the research on behavior modification in stimulant dependence has been less consistent. Cognitive control and behavioral insight are essential to optimal decision making and resisting impulses to engage in risky behaviors (e.g., drug-seeking). This proposal will examine the neural substrates of cognitive control impairments associated with detrimental decision-making in ADHD and MA dependence. Four groups will be studied: 1) Subjects with MA dependence but not ADHD; 2) subjects with MA dependence and ADHD; 3) ADHD subjects without MA dependence and 4) typically developing controls. We will administer a GO/NOGO paradigm manipulated to produce high error rates and will further examine the ability to detect errors and subsequently modify behavior. We will examine behavioral modification under situations of increasing working memory load as well as task related neural activity. Our hypothesis is that the group with ADHD and MA dependence (ADHD+MA) will display the most profound impairments in behavior modification and reduced neural activity in lateral prefrontal cortex under conditions of increased memory load. This hypothesis is based on pre-existing compromised functional activity in brain regions subserving working memory in ADHD and stimulant dependence. Results from this proposed study represent an important first step in identifying the neural and behavioral mechanisms of the interaction between substance abuse and ADHD and determining cognitive control impairments in ADHD+MA. Thus the goal of this proposal is consistent with NIDA's strategic plan IV Cross-Cutting Priorities. PUBLIC HEALTH RELEVANCE: The abuse of substances such as methamphetamine represents a major public health concern. Clinical disorders such as ADHD may put individuals at an increased risk for substance dependence; yet little is known about the neural and cognitive impairments associated with ADHD and substance dependence comorbidity. This project will use functional neuroimaging and targeted measures of cognition to investigate impairments in performance monitoring in ADHD and methamphetamine dependence as well as the interaction between the two disorders. Results will provide valuable insight into impaired decision-making in MA dependence but also the synergistic interaction between ADHD and MA dependence.
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1 |
2015 — 2016 |
Fassbender, Catherine |
R21Activity Code Description: To encourage the development of new research activities in categorical program areas. (Support generally is restricted in level of support and in time.) |
Cognitive and Reward Processes in Risk For Relapse in Poly Substance Dependence @ University of California At Davis
? DESCRIPTION (provided by applicant): Substance use disorders are estimated to affect 20.4 million individuals in the United States with the financial cost of alcohol and substance addiction calculated at half a trillion dollars per year. Drug and alcohol addictions are now recognized as chronic, relapsing disorders, with approximately 60% of individuals relapsing following extended periods of sobriety. Research has identified two major sources of risk for relapse: 1) reward-related factors associated with increased wanting or desire for the substance of abuse; and 2) cognitive control-related factors linked to both the deliberate suppression of these desires as well as reduced attention to environmental and internal triggers. Although studies have investigated each of these systems independent of the other, few have effectively examined the relative contributions of reward- and cognitive control-related factors to relapse. Fewer still hav combined the use of targeted behavioral and neuroimaging measures to examine the underlying neurobiology of risk for relapse in substance use disorder. Furthermore, relapse studies rarely examine vulnerabilities across substances of abuse in poly-substance abusers, preferring to study one primary substance. Poly-substance abuse is arguably far more representative of real-world addiction. The proposed project will use clinically relevant functional neuroimaging and behavioral measures of pure cognitive control and reward-related processes, as well as the relationship between the two, to assess the strongest predictors of relapse in individuals with poly-substance use disorder. Furthermore, unlike many other imaging studies of relapse we will recruit participants in a controlled treatment setting, where we can more reliably ascertain not only the status of participants (relapse vs. no relapse) but also the number of days to relapse. Our goal is to determine whether cognitive control- versus reward-related factors, or their combination, is the stronger predictor of relapse in poly-substance use disorder. Data generated by this R21 will have clinical relevance by offering treatment providers tools to effectively tailo addiction treatments to specific neurobiological vulnerabilities. Results from this proposed study represent an important first step in the development of a longitudinal research program aimed at investigating the neural and psychological risk factors for developing and maintaining substance use disorder in poly-substance abusers. This project would provide pilot data for a larger RO1 proposal to investigate relapse in greater detail, including more comprehensively probing mediators such as social, psychological and clinical risk factors. The goals of this proposal align directly with the interests of CRAN (Collaborative Research on Addiction at NIH) by studying individuals with poly-substance use disorder.
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1 |