Area:
Learning and Memory, animal behavior
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High-probability grants
According to our matching algorithm, John Gibbon is the likely recipient of the following grants.
Years |
Recipients |
Code |
Title / Keywords |
Matching score |
1983 |
Gibbon, John |
N/AActivity Code Description: No activity code was retrieved: click on the grant title for more information |
Partial Support of a Conference On Timing and Time Perception; New York City; May 10-13, 1983 @ New York Academy of Sciences |
0.901 |
1996 — 1999 |
Gibbon, John |
R01Activity Code Description: To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies. |
Function and Neuronal Mechanisms of Interval Timing @ Columbia Univ New York Morningside
Over the past several years, much empirical and theoretical effort has been devoted to understanding the interval time sense, processing of durations of the order of seconds, in animals. A coherent theoretical description of the central components of temporal processing has been elaborated, encompassing a wide variety of animal learning and psychophysics paradigms. More recently many of these paradigms have been studied with humans, confirming central features of our account. This and the companion proposal from Meck, extends this parallel study of human and animal timing. The present proposal is devoted to these paradigms in normative human populations and in patient populations with disorders of the basal ganglia showing aberrant temporal processing. Disorders of the basal ganglia interfere with certain components of temporal processing systems and present a profile of different kinds of dysfunctions associated with neural damage to different structures. This proposal contrasts these patient populations with normative data in experiments designed to reveal distinct components of cognitive impairment in temporal processing associated with distinct neural damage in striato-cortical networks. Two major classes of cognitive dysfunction are studied: one involving distortions in memory storage and/or retrieval of temporal information, and another specific to simultaneous processing of temporal information. The former is sensitive to dopaminergic regulation and the latter is associated with damage to structures in the striatum.
|
0.939 |
2000 |
Gibbon, John |
R01Activity Code Description: To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies. |
Functional and Neuronal Mechanism of Interval Timing @ Columbia Univ New York Morningside
The present proposal is a competing continuation of a project studying the functional and neural mechanisms of temporal processing in patient populations with Parkinson's Disease (PD). The previous work has dissociated storage (encoding) and retrieval (decoding) deficits, and isolated specific neural substrates of temporal processing with distinct cognitive deficits. Parallel effects have been seen with normal aging as well, and are isolated to the time domain. The continuation would follow these results in five different directions: (1) Further work with Parkinson's patients ON/OFF Levodopa medication is designed to clarify the etiology of different dysfunctional components as these develop early (de novo) and later in the disease; (2) chronic deep brain stimulation (DBS) will be used to isolate dysfunctions to particular structures in the basal ganglia, particularly the subthalamic nucleus (STn) and the internal and external portions of the globus pallidus. Stimulation of the pallidus will be contrasted with comparable performance by patients before and after therapeutic pallidotomy; (3) some but not all of the temporal processing dysfunctions observed in PD have been seen in aged populations as well. The role of feedback, shown to be an important factor in temporal learning and memory for the aged is studied with designs which separate memory updating from strategic adjustment; (4) work with rats using comparable procedures to separate storage from retrieval processes under dopamine (DA) antagonists has begun with a single time value. This will be expanded to two time values and DA agonists as well; and finally, (5) theoretical work on the project is ongoing, studying an adaptation of a connectionist pacemaker/accumulator model (Miall, 1992). This modeling permits study of a non-linear stochastic systems, which are forced by retrieval in our DA data.
|
0.939 |