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Lei Hu

Affiliations: 
Columbia University, New York, NY 
Area:
BK channels, HCN channels
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"Lei Hu"
Mean distance: 13.98 (cluster 11)
 		SNBCP
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Parents

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Jianmin Cui grad student 2001-2007 Washington University
Steven A. Siegelbaum post-doc 2007- Columbia University Medical School

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Publications

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Saponaro A, Pauleta SR, Cantini F, et al. (2014) Structural basis for the mutual antagonism of cAMP and TRIP8b in regulating HCN channel function. Proceedings of the National Academy of Sciences of the United States of America. 111: 14577-82
Siegelbaum SA, Hu L, Santoro B. (2014) TRIP(8B)Ing up and Down HCN Channel Gating and Trafficking Biophysical Journal. 106: 9a
Hu L, Santoro B, Saponaro A, et al. (2013) Binding of the auxiliary subunit TRIP8b to HCN channels shifts the mode of action of cAMP. The Journal of General Physiology. 142: 599-612
Hu L, Santoro B, Saponaro A, et al. (2012) TRIP8B Allosterically Regulates the Ability of cAMP to Enhance the HCN2 Channel Opening Biophysical Journal. 102: 130a
Santoro B, Hu L, Liu H, et al. (2011) TRIP8b regulates HCN1 channel trafficking and gating through two distinct C-terminal interaction sites. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 4074-86
Chen YH, Hu L, Punta M, et al. (2010) Homologue structure of the SLAC1 anion channel for closing stomata in leaves. Nature. 467: 1074-80
Santoro B, Piskorowski RA, Pian P, et al. (2009) TRIP8b splice variants form a family of auxiliary subunits that regulate gating and trafficking of HCN channels in the brain. Neuron. 62: 802-13
Yang H, Hu L, Shi J, et al. (2007) Mg2+ mediates interaction between the voltage sensor and cytosolic domain to activate BK channels. Proceedings of the National Academy of Sciences of the United States of America. 104: 18270-5
Yang H, Hu L, Shi J, et al. (2006) Tuning magnesium sensitivity of BK channels by mutations. Biophysical Journal. 91: 2892-900
Hu L, Yang H, Shi J, et al. (2006) Effects of multiple metal binding sites on calcium and magnesium-dependent activation of BK channels. The Journal of General Physiology. 127: 35-49
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