Adam G. Walker, Ph.D.

Drug Discovery Vanderbilt University, Nashville, TN 
"Adam Walker"
Mean distance: 14.73 (cluster 19)


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M Todd Allen research assistant University of Northern Colorado
George V. Rebec grad student 2010 Indiana University
 (The prefrontal cortex system in the R6/2 mouse model of Huntington's disease.)
Jeffrey P. Conn post-doc Vanderbilt University Medical Center
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Gogliotti RG, Senter RK, Fisher NM, et al. (2017) mGlu7 potentiation rescues cognitive, social, and respiratory phenotypes in a mouse model of Rett syndrome. Science Translational Medicine. 9
Walker AG, Sheffler DJ, Lewis AS, et al. (2017) Co-Activation of Metabotropic Glutamate Receptor 3 and Beta-Adrenergic Receptors Modulates Cyclic-AMP, Long-Term Potentiation, and Disrupts Memory Reconsolidation. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
Senter RK, Ghoshal A, Walker AG, et al. (2016) The Role of mGlu Receptors in Hippocampal Plasticity Deficits in Neurological and Psychiatric Disorders: Implications for Allosteric Modulators as Novel Therapeutic Strategies. Current Neuropharmacology. 14: 455-73
Klar R, Walker AG, Ghose D, et al. (2015) Activation of Metabotropic Glutamate Receptor 7 Is Required for Induction of Long-Term Potentiation at SC-CA1 Synapses in the Hippocampus. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 7600-15
Walker AG, Wenthur CJ, Xiang Z, et al. (2015) Metabotropic glutamate receptor 3 activation is required for long-term depression in medial prefrontal cortex and fear extinction. Proceedings of the National Academy of Sciences of the United States of America. 112: 1196-201
Walker AG, Conn PJ. (2015) Group I and group II metabotropic glutamate receptor allosteric modulators as novel potential antipsychotics. Current Opinion in Pharmacology. 20: 40-5
Jalan-Sakrikar N, Field JR, Klar R, et al. (2014) Identification of positive allosteric modulators VU0155094 (ML397) and VU0422288 (ML396) reveals new insights into the biology of metabotropic glutamate receptor 7. Acs Chemical Neuroscience. 5: 1221-37
Digby GJ, Noetzel MJ, Bubser M, et al. (2012) Novel allosteric agonists of M1 muscarinic acetylcholine receptors induce brain region-specific responses that correspond with behavioral effects in animal models. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 8532-44
Field JR, Walker AG, Conn PJ. (2011) Targeting glutamate synapses in schizophrenia. Trends in Molecular Medicine. 17: 689-98
Miller BR, Walker AG, Barton SJ, et al. (2011) Dysregulated Neuronal Activity Patterns Implicate Corticostriatal Circuit Dysfunction in Multiple Rodent Models of Huntington's Disease. Frontiers in Systems Neuroscience. 5: 26
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