Selwyn S. Jayakar, Ph.D.

Area:
nicotinic receptors, neuropeptides
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"Selwyn Jayakar"
Mean distance: 17.37 (cluster 16)
 

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Joseph F. Margiotta grad student 2009 The University of Toledo
 (Abl family kinases regulate neuronal nicotinic receptors and synapses in chick ciliary ganglion neurons.)
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Publications

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McGrath M, Hoyt H, Pence A, et al. (2020) Competitive Antagonism of Etomidate Action by Diazepam: In Vitro GABAA Receptor and In Vivo Zebrafish Studies. Anesthesiology
Jayakar SS, Chiara DC, Zhou X, et al. (2020) Photoaffinity labeling identifies an intersubunit steroid-binding site in heteromeric GABA type A (GABA) receptors. The Journal of Biological Chemistry
Jayakar SS, Zhou X, Chiara DC, et al. (2019) Identifying drugs that bind selectively to intersubunit general anesthetic sites in the α1β3γ2 GABAR transmembrane domain. Molecular Pharmacology
Wu B, Jayakar SS, Zhou X, et al. (2018) Inhibitable photolabeling by neurosteroid diazirine analog in the β3-Subunit of human hetereopentameric type A GABA receptors. European Journal of Medicinal Chemistry. 162: 810-824
McGrath M, Yu Z, Jayakar SS, et al. (2018) Etomidate and Etomidate Analog Binding and Positive Modulation of γ-Aminobutyric Acid Type A Receptors: Evidence for a State-dependent Cutoff Effect. Anesthesiology
Ma C, Pejo E, McGrath M, et al. (2017) Competitive Antagonism of Anesthetic Action at the γ-Aminobutyric Acid Type A Receptor by a Novel Etomidate Analog with Low Intrinsic Efficacy. Anesthesiology
Mohamed TS, Jayakar SS, Hamouda AK. (2015) Orthosteric and Allosteric Ligands of Nicotinic Acetylcholine Receptors for Smoking Cessation. Frontiers in Molecular Neuroscience. 8: 71
Jayakar SS, Zhou X, Savechenkov PY, et al. (2015) Positive and Negative Allosteric Modulation of an α1β3γ2 γ-Aminobutyric acid Type A (GABAA) Receptor by Binding to a Site in the Transmembrane Domain at the γ+-β- Interface. The Journal of Biological Chemistry
Jayakar SS, Pugh PC, Dale Z, et al. (2014) PACAP induces plasticity at autonomic synapses by nAChR-dependent NOS1 activation and AKAP-mediated PKA targeting. Molecular and Cellular Neurosciences. 63: 1-12
Jayakar SS, Zhou X, Chiara DC, et al. (2014) Multiple propofol-binding sites in a γ-aminobutyric acid type A receptor (GABAAR) identified using a photoreactive propofol analog. The Journal of Biological Chemistry. 289: 27456-68
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