Erin J. Whalen, Ph.D.

Affiliations: 
University of Iowa, Iowa City, IA 
Area:
mood, thirst, cardiovascular homeostasis
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Mean distance: 16.7 (cluster 19)
 
SNBCP

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Alan K. Johnson grad student 2000 University of Iowa
 (Nitrosyl factors regulate G(S) protein-coupled receptor signal transduction in vivo.)
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Publications

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Whalen EJ, Johnson AK, Lewis SJ. (2014) Hemodynamic responses elicited by systemic injections of isotonic and hypertonic saline in hemorrhaged rats. Microvascular Research. 91: 22-9
Zennadi R, Whalen EJ, Soderblom EJ, et al. (2012) Erythrocyte plasma membrane-bound ERK1/2 activation promotes ICAM-4-mediated sickle red cell adhesion to endothelium. Blood. 119: 1217-27
Hara MR, Kovacs JJ, Whalen EJ, et al. (2011) A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1. Nature. 477: 349-53
Boerrigter G, Lark MW, Whalen EJ, et al. (2011) Cardiorenal actions of TRV120027, a novel ß-arrestin-biased ligand at the angiotensin II type I receptor, in healthy and heart failure canines: a novel therapeutic strategy for acute heart failure. Circulation. Heart Failure. 4: 770-8
Whalen EJ, Rajagopal S, Lefkowitz RJ. (2011) Therapeutic potential of β-arrestin- and G protein-biased agonists. Trends in Molecular Medicine. 17: 126-39
Violin JD, DeWire SM, Yamashita D, et al. (2010) Selectively engaging β-arrestins at the angiotensin II type 1 receptor reduces blood pressure and increases cardiac performance. The Journal of Pharmacology and Experimental Therapeutics. 335: 572-9
Xie L, Xiao K, Whalen EJ, et al. (2009) Oxygen-regulated beta(2)-adrenergic receptor hydroxylation by EGLN3 and ubiquitylation by pVHL. Science Signaling. 2: ra33
Zidar DA, Violin JD, Whalen EJ, et al. (2009) Selective engagement of G protein coupled receptor kinases (GRKs) encodes distinct functions of biased ligands. Proceedings of the National Academy of Sciences of the United States of America. 106: 9649-54
Walters RW, Shukla AK, Kovacs JJ, et al. (2009) beta-Arrestin1 mediates nicotinic acid-induced flushing, but not its antilipolytic effect, in mice. The Journal of Clinical Investigation. 119: 1312-21
Kim IM, Tilley DG, Chen J, et al. (2008) Beta-blockers alprenolol and carvedilol stimulate beta-arrestin-mediated EGFR transactivation. Proceedings of the National Academy of Sciences of the United States of America. 105: 14555-60
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