Juliette Gafni, Ph.D.
Affiliations: | University of California, Davis, Davis, CA |
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"Juliette Gafni"Mean distance: 15.62 (cluster 6) | S | N | B | C | P |
Parents
Sign in to add mentor| Karen A. Sigvardt | grad student | 2000 | UC Davis | |
| (Novel modulators of microsomal calcium release.) | ||||
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Publications
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| Miller JP, Yates BE, Al-Ramahi I, et al. (2012) A genome-scale RNA-interference screen identifies RRAS signaling as a pathologic feature of Huntington's disease. Plos Genetics. 8: e1003042 |
| Gafni J, Papanikolaou T, Degiacomo F, et al. (2012) Caspase-6 activity in a BACHD mouse modulates steady-state levels of mutant huntingtin protein but is not necessary for production of a 586 amino acid proteolytic fragment. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 7454-65 |
| Leyva MJ, Degiacomo F, Kaltenbach LS, et al. (2010) Identification and evaluation of small molecule pan-caspase inhibitors in Huntington's disease models. Chemistry & Biology. 17: 1189-200 |
| Miller JP, Holcomb J, Al-Ramahi I, et al. (2010) Matrix metalloproteinases are modifiers of huntingtin proteolysis and toxicity in Huntington's disease. Neuron. 67: 199-212 |
| Landles C, Sathasivam K, Weiss A, et al. (2010) Proteolysis of mutant huntingtin produces an exon 1 fragment that accumulates as an aggregated protein in neuronal nuclei in Huntington disease. The Journal of Biological Chemistry. 285: 8808-23 |
| Gafni J, Cong X, Chen SF, et al. (2009) Calpain-1 cleaves and activates caspase-7. The Journal of Biological Chemistry. 284: 25441-9 |
| Schilling B, Gafni J, Torcassi C, et al. (2006) Huntingtin phosphorylation sites mapped by mass spectrometry. Modulation of cleavage and toxicity. The Journal of Biological Chemistry. 281: 23686-97 |
| Tanaka Y, Igarashi S, Nakamura M, et al. (2006) Progressive phenotype and nuclear accumulation of an amino-terminal cleavage fragment in a transgenic mouse model with inducible expression of full-length mutant huntingtin. Neurobiology of Disease. 21: 381-91 |
| Jin K, LaFevre-Bernt M, Sun Y, et al. (2005) FGF-2 promotes neurogenesis and neuroprotection and prolongs survival in a transgenic mouse model of Huntington's disease. Proceedings of the National Academy of Sciences of the United States of America. 102: 18189-94 |
| Gafni J, Hermel E, Young JE, et al. (2004) Inhibition of calpain cleavage of huntingtin reduces toxicity: accumulation of calpain/caspase fragments in the nucleus. The Journal of Biological Chemistry. 279: 20211-20 |