Seungkirl Ahn, Ph.D.

Affiliations: 
Duke University, Durham, NC 
Area:
G protein-coupled receptors
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"Seungkirl Ahn"
Mean distance: 15.45 (cluster 11)
 
SNBCP

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Robert J. Lefkowitz grad student 2002 Duke
 (Tyrosine phosphorylation of dynamin: A novel regulatory mechanism for receptor -mediated endocytosis.)
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Publications

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Ahn S, Shenoy SK, Luttrell LM, et al. (2020) SnapShot: β-Arrestin Functions. Cell. 182: 1362-1362.e1
Liu X, Masoudi A, Kahsai AW, et al. (2019) Mechanism of βAR regulation by an intracellular positive allosteric modulator. Science (New York, N.Y.). 364: 1283-1287
Luttrell LM, Wang J, Plouffe B, et al. (2018) Manifold roles of β-arrestins in GPCR signaling elucidated with siRNA and CRISPR/Cas9. Science Signaling. 11
Choi M, Staus DP, Wingler LM, et al. (2018) G protein-coupled receptor kinases (GRKs) orchestrate biased agonism at the β-adrenergic receptor. Science Signaling. 11
Ahn S, Pani B, Kahsai AW, et al. (2018) Small Molecule Positive Allosteric Modulators of the β-Adrenoceptor Isolated from DNA Encoded Libraries. Molecular Pharmacology
Meng K, Shim P, Wang Q, et al. (2018) Design, synthesis, and functional assessment of Cmpd-15 derivatives as negative allosteric modulators for the β-adrenergic receptor. Bioorganic & Medicinal Chemistry
Liu X, Ahn S, Kahsai AW, et al. (2017) Mechanism of intracellular allosteric β2AR antagonist revealed by X-ray crystal structure. Nature
Ahn S, Kahsai AW, Pani B, et al. (2017) Allosteric "beta-blocker" isolated from a DNA-encoded small molecule library. Proceedings of the National Academy of Sciences of the United States of America
Staus DP, Strachan RT, Manglik A, et al. (2016) Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation. Nature
Kahsai AW, Wisler JW, Lee J, et al. (2016) Conformationally selective RNA aptamers allosterically modulate the β2-adrenoceptor. Nature Chemical Biology
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