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Lauren C. Purington, Ph.D.

Affiliations: 
University of Michigan, Ann Arbor, Ann Arbor, MI 
Area:
Opiod signal transductions, addiction
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"Lauren Purington"
Mean distance: 21373.2
 
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John R. Traynor grad student 2011 University of Michigan
 (Investigating interactions between mu and delta opioid receptors using bifunctional peptides.)

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Publications

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Moynihan HA, Derrick I, Broadbear JH, et al. (2012) Fumaroylamino-4,5-epoxymorphinans and related opioids with irreversible μ opioid receptor antagonist effects. Journal of Medicinal Chemistry. 55: 9868-74
Anand JP, Purington LC, Pogozheva ID, et al. (2012) Modulation of opioid receptor ligand affinity and efficacy using active and inactive state receptor models. Chemical Biology & Drug Design. 80: 763-70
Purington LC, Sobczyk-Kojiro K, Pogozheva ID, et al. (2011) Development and in vitro characterization of a novel bifunctional μ-agonist/δ-antagonist opioid tetrapeptide. Acs Chemical Biology. 6: 1375-81
Levitt ES, Purington LC, Traynor JR. (2011) Gi/o-coupled receptors compete for signaling to adenylyl cyclase in SH-SY5Y cells and reduce opioid-mediated cAMP overshoot. Molecular Pharmacology. 79: 461-71
Nieland NP, Rennison D, Broadbear JH, et al. (2009) 14beta-Arylpropiolylamino-17-cyclopropylmethyl-7,8-dihydronormorphinones and related opioids. Further examples of pseudoirreversible mu opioid receptor antagonists. Journal of Medicinal Chemistry. 52: 6926-30
Purington LC, Pogozheva ID, Traynor JR, et al. (2009) Pentapeptides displaying mu opioid receptor agonist and delta opioid receptor partial agonist/antagonist properties. Journal of Medicinal Chemistry. 52: 7724-31
Moynihan H, Jales AR, Greedy BM, et al. (2009) 14 beta-O-cinnamoylnaltrexone and related dihydrocodeinones are mu opioid receptor partial agonists with predominant antagonist activity. Journal of Medicinal Chemistry. 52: 1553-7
Cami-Kobeci G, Neal AP, Bradbury FA, et al. (2009) Mixed kappa/mu opioid receptor agonists: the 6 beta-naltrexamines. Journal of Medicinal Chemistry. 52: 1546-52
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