Paul Temkin, Ph.D.

Affiliations: 
2005-2012 Cell Biology University of California, San Francisco, San Francisco, CA 
 2012-2018 Psychiatry and Behavioral Sciences Stanford University School of Medicine, Palo Alto, CA, United States 
 2018- Neurodegeneration Biogen, Morrisville, NC, United States 
Area:
GPCR trafficking, GPCR signalling, AMPAR trafficking, LTP, Parkinson's
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SNBCP

Parents

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Mark von Zastrow grad student 2011 UCSF
 (Elucidating the Post-Endocytic Sorting Mechanism of the Beta-2 Adrenergic Receptor.)
Robert C. Malenka post-doc 2012- Stanford Medical School

Children

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Dan Montagna grad student 2021- Biogen
Andy Y Gao post-doc 2021- Biogen
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Publications

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Bhouri M, Morishita W, Temkin P, et al. (2018) Deletion of in adult mice impairs basal AMPA receptor transmission and LTP in hippocampal CA1 pyramidal neurons. Proceedings of the National Academy of Sciences of the United States of America
Temkin P, Morishita W, Goswami D, et al. (2017) The Retromer Supports AMPA Receptor Trafficking During LTP. Neuron. 94: 74-82.e5
Schwartz N, Temkin P, Jurado S, et al. (2014) Chronic pain. Decreased motivation during chronic pain requires long-term depression in the nucleus accumbens. Science (New York, N.Y.). 345: 535-42
Choy RW, Park M, Temkin P, et al. (2014) Retromer mediates a discrete route of local membrane delivery to dendrites. Neuron. 82: 55-62
Temkin P, Lauffer B, Jäger S, et al. (2011) SNX27 mediates retromer tubule entry and endosome-to-plasma membrane trafficking of signalling receptors. Nature Cell Biology. 13: 715-21
Puthenveedu MA, Lauffer B, Temkin P, et al. (2010) Sequence-dependent sorting of recycling proteins by actin-stabilized endosomal microdomains. Cell. 143: 761-73
Lauffer BE, Melero C, Temkin P, et al. (2010) SNX27 mediates PDZ-directed sorting from endosomes to the plasma membrane. The Journal of Cell Biology. 190: 565-74
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