Ryan G. Holzer, Ph.D.

Affiliations: 
Biomedical Sciences University of California, San Diego, La Jolla, CA 
Area:
immunology
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"Ryan Holzer"
Mean distance: 21.26 (cluster 6)
 

Parents

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Michael Karin grad student 2010 UCSD
 (Lipid Raft-Associated c-Src Mediates JNK Activation and Insulin Resistance in Response to Saturated Free Fatty Acids.)
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Publications

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Li N, Wu X, Holzer RG, et al. (2013) Loss of acinar cell IKKα triggers spontaneous pancreatitis in mice. The Journal of Clinical Investigation. 123: 2231-43
Holzer RG, Park EJ, Li N, et al. (2011) Saturated fatty acids induce c-Src clustering within membrane subdomains, leading to JNK activation. Cell. 147: 173-84
Park EJ, Lee JH, Yu GY, et al. (2010) Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression. Cell. 140: 197-208
Holzer R, Tran H, Salinas G, et al. (2010) Abstract 38: Saturated free fatty acids activate a c-Src-JNK1 axis within lipid rafts: Implications for the development of insulin resistance, obesity, and obesity-associated cancer Cancer Research. 70: 38-38
Gallagher E, Enzler T, Matsuzawa A, et al. (2007) Kinase MEKK1 is required for CD40-dependent activation of the kinases Jnk and p38, germinal center formation, B cell proliferation and antibody production. Nature Immunology. 8: 57-63
Jorcyk CL, Holzer RG, Ryan RE. (2006) Oncostatin M induces cell detachment and enhances the metastatic capacity of T-47D human breast carcinoma cells. Cytokine. 33: 323-36
MacDougall CA, Vargas M, Soares CR, et al. (2005) Involvement of HGF/SF-Met signaling in prostate adenocarcinoma cells: evidence for alternative mechanisms leading to a metastatic phenotype in Pr-14c. The Prostate. 64: 139-48
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