Feng Yan, Ph.D.

Affiliations: 
Case Western Reserve University, Cleveland Heights, OH, United States 
Area:
Psychopharmacology, 5-HT2A receptors, hallucinogens
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"Feng Yan"
Mean distance: 15.89 (cluster 6)
 
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Bryan L. Roth grad student 2008 Case Western
 (Molecular mechanisms by which salvinorin A binds to and activates the kappa-opioid receptor.)
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Publications

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Fichna J, Lewellyn K, Yan F, et al. (2011) Synthesis and biological evaluation of new salvinorin A analogues incorporating natural amino acids. Bioorganic & Medicinal Chemistry Letters. 21: 160-3
Yan F, Bikbulatov RV, Mocanu V, et al. (2009) Structure-based design, synthesis, and biochemical and pharmacological characterization of novel salvinorin A analogues as active state probes of the kappa-opioid receptor. Biochemistry. 48: 6898-908
Bikbulatov RV, Stewart J, Jin W, et al. (2008) Short synthesis of a novel class of salvinorin A analogs with hemiacetalic structure. Tetrahedron Letters. 49: 937-940
Pei Y, Rogan SC, Yan F, et al. (2008) Engineered GPCRs as tools to modulate signal transduction. Physiology (Bethesda, Md.). 23: 313-21
Yan F, Mosier PD, Westkaemper RB, et al. (2008) Galpha-subunits differentially alter the conformation and agonist affinity of kappa-opioid receptors. Biochemistry. 47: 1567-78
Bikbulatov RV, Yan F, Roth BL, et al. (2007) Convenient synthesis and in vitro pharmacological activity of 2-thioanalogs of salvinorins A and B. Bioorganic & Medicinal Chemistry Letters. 17: 2229-32
Stewart DJ, Fahmy H, Roth BL, et al. (2006) Bioisosteric modification of salvinorin A, a potent and selective kappa-opioid receptor agonist. Arzneimittel-Forschung. 56: 269-75
Beeler AB, Acquilano DE, Su Q, et al. (2005) Synthesis of a library of complex macrodiolides employing cyclodimerization of hydroxy esters. Journal of Combinatorial Chemistry. 7: 673-81
Yan F, Mosier PD, Westkaemper RB, et al. (2005) Identification of the molecular mechanisms by which the diterpenoid salvinorin A binds to kappa-opioid receptors. Biochemistry. 44: 8643-51
Munro TA, Rizzacasa MA, Roth BL, et al. (2005) Studies toward the pharmacophore of salvinorin A, a potent kappa opioid receptor agonist. Journal of Medicinal Chemistry. 48: 345-8
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