Layla Azam, Ph.D.

Affiliations: 
University of California, Irvine, Irvine, CA 
Area:
Brain development, drug abuse, nicotine
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"Layla Azam"
Mean distance: 17.04 (cluster 41)
 
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Parents

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Frances M. Leslie grad student 2001 UC Irvine
 (Characterization of nicotinic acetylcholine receptors within rat brain monoaminergic neurons.)
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Publications

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Hone AJ, McIntosh JM, Azam L, et al. (2015) α-Conotoxins Identify the α3β4* Subtype as the Predominant Nicotinic Acetylcholine Receptor Expressed in Human Adrenal Chromaffin Cells. Molecular Pharmacology. 88: 881-93
Azam L, Papakyriakou A, Zouridakis M, et al. (2015) Molecular interaction of α-conotoxin RgIA with the rat α9α10 nicotinic acetylcholine receptor. Molecular Pharmacology. 87: 855-64
Zhang MM, Gajewiak J, Azam L, et al. (2015) Probing the Redox States of Sodium Channel Cysteines at the Binding Site of μO§-Conotoxin GVIIJ Biochemistry. 54: 3911-3920
Gajewiak J, Azam L, Imperial J, et al. (2014) A disulfide tether stabilizes the block of sodium channels by the conotoxin μO§-GVIIJ. Proceedings of the National Academy of Sciences of the United States of America. 111: 2758-63
Hone AJ, Ruiz M, Scadden M, et al. (2013) Positional scanning mutagenesis of α-conotoxin PeIA identifies critical residues that confer potency and selectivity for α6/α3β2β3 and α3β2 nicotinic acetylcholine receptors. The Journal of Biological Chemistry. 288: 25428-39
Zhang MM, Wilson MJ, Azam L, et al. (2013) Co-expression of Na(V)β subunits alters the kinetics of inhibition of voltage-gated sodium channels by pore-blocking μ-conotoxins. British Journal of Pharmacology. 168: 1597-610
Wilson MJ, Yoshikami D, Azam L, et al. (2011) μ-Conotoxins that differentially block sodium channels NaV1.1 through 1.8 identify those responsible for action potentials in sciatic nerve. Proceedings of the National Academy of Sciences of the United States of America. 108: 10302-7
Wilson MJ, Zhang MM, Azam L, et al. (2011) Navβ subunits modulate the inhibition of Nav1.8 by the analgesic gating modifier μO-conotoxin MrVIB. The Journal of Pharmacology and Experimental Therapeutics. 338: 687-93
Azam L, Maskos U, Changeux JP, et al. (2010) α-Conotoxin BuIA[T5A;P6O]: a novel ligand that discriminates between α6ß4 and α6ß2 nicotinic acetylcholine receptors and blocks nicotine-stimulated norepinephrine release. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 24: 5113-23
Zhang MM, McArthur JR, Azam L, et al. (2009) Synergistic and antagonistic interactions between tetrodotoxin and mu-conotoxin in blocking voltage-gated sodium channels. Channels (Austin, Tex.). 3: 32-8
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