David B. Sykes, Ph.D.
Affiliations: | University of California, San Diego, La Jolla, CA |
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"David Sykes"Mean distance: 17.6 (cluster 32) | S | N | B | C | P |
Parents
Sign in to add mentor| Mark Kamps | grad student | 2002 | UCSD | |
| (Conditional versions of E2a /Pbx1 provide cell-based systems to dissect the mechanism by which E2a/Pbx1 establishes myeloid and lymphoid differentiation arrest.) | ||||
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Publications
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| Kfoury YS, Ji F, Jain E, et al. (2023) The bone marrow stroma in human myelodysplastic syndrome reveals alterations that regulate disease progression. Blood Advances |
| Rhee C, Scadden EW, Wong LP, et al. (2023) Limited plasticity of monocyte fate and function associated with epigenetic scripting at the level of progenitors. Blood |
| Blanco MA, Sykes DB, Gu L, et al. (2021) Chromatin-state barriers enforce an irreversible mammalian cell fate decision. Cell Reports. 37: 109967 |
| van Gastel N, Spinelli JB, Sharda A, et al. (2020) Induction of a Timed Metabolic Collapse to Overcome Cancer Chemoresistance. Cell Metabolism |
| Yusuf R, Saez B, Sharda A, et al. (2020) Aldehyde dehydrogenase 3a2 protects AML cells from oxidative death and the synthetic lethality of ferroptosis inducers. Blood |
| Negoro PE, Xu S, Dagher Z, et al. (2020) Spleen Tyrosine Kinase Is a Critical Regulator of Neutrophil Responses to Species. Mbio. 11 |
| Nguyen GT, Shaban L, Mack M, et al. (2020) SKAP2 is required for defense against infection and neutrophil respiratory burst. Elife. 9 |
| Cabal-Hierro L, van Galen P, Prado MA, et al. (2020) Chromatin accessibility promotes hematopoietic and leukemia stem cell activity. Nature Communications. 11: 1406 |
| Lee S, Micalizzi D, Truesdell SS, et al. (2020) A post-transcriptional program of chemoresistance by AU-rich elements and TTP in quiescent leukemic cells. Genome Biology. 21: 33 |
| Christian S, Merz C, Evans L, et al. (2019) The novel dihydroorotate dehydrogenase (DHODH) inhibitor BAY 2402234 triggers differentiation and is effective in the treatment of myeloid malignancies. Leukemia |